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Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.
It is demonstrated that genetic ablation of Nceh1 promotes foam cell formation and the development of Atherosclerosis in mice and is a promising target for the treatment of atherosclerosis. Expand
Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages[S]
An excess of cholesterol and/or oxysterols induces apoptosis in macrophages, contributing to the development of advanced atherosclerotic lesions. In foam cells, these sterols are stored in esterifiedExpand
Selective Inhibition of Acyl-CoA:cholesterol Acyltransferase 2 Isozyme by Flavasperone and Sterigmatocystin from Aspergillus Species
Five known fungal metabolites were isolated from the culture broths of Aspergillus species as inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT) in the cell-based assay using ACAT1- and ACAT2-expressing CHO cells and flavasperone and sterigmatocystin showed selective inhibition toward ACat2 isozyme. Expand
Pyripyropene A, an Acyl–Coenzyme A: Cholesterol Acyltransferase 2–Selective Inhibitor, Attenuates Hypercholesterolemia and Atherosclerosis in Murine Models of Hyperlipidemia
The findings indicate that ACAT2-selective inhibition in the intestine and the liver can be effective against atherosclerosis and that PPPA appears to be a potential antiatherogenic lead compound. Expand
Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice.
It is indicated that IL- 17 deficiency reduces vascular inflammation and atherosclerosis and that modulation of IL-17 could be a potential target for prevention and treatment of atheros sclerosis. Expand
Spylidone, a Novel Inhibitor of Lipid Droplet Accumulation in Mouse Macrophages Produced by Phoma sp. FKI-1840
Among the three compounds, only spylidone was found to inhibit lipid droplet accumulation in macrophages at 10∼50 µM without any cytotoxic effect. Expand
Fungal isobisvertinol, a new inhibitor of lipid droplet accumulation in mouse macrophages.
Isobisvertinol with the two alkenyl side chains extending in the same direction inhibited lipid droplet accumulation in macrophages, whereas bisvertinols with those extended in the reverse direction had almost no effect on the accumulation. Expand
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1.
Novel PPPA derivatives with a 7-O-substituted benzoyl substituent that significantly exhibit more potent ACat2 inhibitory activity and higher ACAT2 isozyme selectivity than 1. Expand
7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus ungui NKH-007
A new depsidone, named 7-chlorofolipastatin, and five known structurally related depsidones were isolated from the culture broth of the marine-derived fungus Aspergillus ungui NKM-007 by solventExpand