Penicillium griseofulvum F1959, high-production strain of pyripyropene a, specific inhibitor of acyl-CoA: cholesterol acyltransferase 2.

@article{Choi2008PenicilliumGF,
  title={Penicillium griseofulvum F1959, high-production strain of pyripyropene a, specific inhibitor of acyl-CoA: cholesterol acyltransferase 2.},
  author={Jung Ho Choi and M J Rho and Seung Woong Lee and Ji Young Choi and Hee Jeong Lee and Kyung Sook Bae and Koanhoi Kim and Young Kook Kim},
  journal={Journal of microbiology and biotechnology},
  year={2008},
  volume={18 10},
  pages={1663-5}
}
Acyl-coenzyme A: cholesterol acyltransferase (ACAT) catalyzes cholesterol esterification and plays an important role in the intestinal absorption of cholesterol, hepatic production of lipoproteins, and accumulation of cholesteryl ester within cells. During the course of screening to find ACAT inhibitors from microbial sources, the present authors isolated pyripyropene A from Penicillium griseofulvum F1959. Pyripyropene A, an ACAT2-specific inhibitor, has already been produced from Aspergillus… CONTINUE READING

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