H. Yamazaki

Publications169
h-index26
Citations2,596
Highly Influential Citations64
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Elements of Neural Adhesion Molecules and a Yeast Vacuolar Protein Sorting Receptor Are Present in a Novel Mammalian Low Density Lipoprotein Receptor Family Member*
TLDR
The identification of this highly conserved and superbly complex protein offers the opportunity to gain new insights into the emergence of multifunctional mosaic proteins akin to the ever expanding LDL receptor gene family. Expand
Statin-induced Krüppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses.
TLDR
It is concluded that statins reduce inflammatory functions and pathogenic activity of T cells through KLF2-dependent mechanisms, and this pathway may be a potential therapeutic target for cardiovascular diseases. Expand
Differential expression of LR11 during proliferation and differentiation of cultured neuroblastoma cells.
TLDR
The transcription of LR11 in these two cell systems is regulated differently during proliferation and differentiation, suggesting that the multifunctionality ofLR11, as well as other LDLR family members, for rapid cell growth in malignant cells and neural outgrowth in cultured neurons, respectively. Expand
Effect of pitavastatin on apolipoprotein A-I production in HepG2 cell.
TLDR
The results suggest that pitavastatin efficiently increases apoA-I in the culture medium of HepG2 cells by promoting apo a-I production through inhibition of HMG-CoA reductase and suppression of Rho activity and by protecting apo A-I from catabolism through ABCA1 induction and lipidation of apo-I. Expand
New rugulosins, anti-MRSA antibiotics, produced by Penicillium radicum FKI-3765-2.
TLDR
Rugulosin A to C showed antimicrobial activity against methicillin-resistant Staphylococcus aureus and new rugulosins B and C were a homodimer of the same anthraquinone moieties. Expand
A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins.
TLDR
The dominant effects of the CETP missense mutation during cellular expression probably explains why the probands have markedly increased HDL in the heterozygous state, and suggests that the active molecular species of CETP may be multimeric. Expand
A novel mosaic protein containing LDL receptor elements is highly conserved in humans and chickens.
TLDR
The expression and molecular structures of a representative of a newly identified branch whose members are expressed in brain, in addition to other tissues, are discovered and delineated. Expand
LR11, an LDL Receptor Gene Family Member, Is a Novel Regulator of Smooth Muscle Cell Migration
TLDR
The novel mechanism of regulation of uPAR localization in SMCs accompanied with enhanced migration activity possibly constitutes an important factor in the process of atherosclerosis and arterial remodeling. Expand
Analysis of the global RNA expression profiles of skeletal muscle cells treated with statins.
TLDR
Results provide basic information on skeletal muscle cells treated with statins and indicate that the cells are sensitive to the inhibition of HMG-CoA reductase, which may be related to the pathogenesis of muscle damage in statin therapy. Expand
Papuamine causes autophagy following the reduction of cell survival through mitochondrial damage and JNK activation in MCF-7 human breast cancer cells
TLDR
The results indicate that papuamine causes earlier onset autophagy and delayed reduction of cell survival through mitochondrial damage and JNK activation in MCF-7 cells. Expand
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