Elements of Neural Adhesion Molecules and a Yeast Vacuolar Protein Sorting Receptor Are Present in a Novel Mammalian Low Density Lipoprotein Receptor Family Member*
The identification of this highly conserved and superbly complex protein offers the opportunity to gain new insights into the emergence of multifunctional mosaic proteins akin to the ever expanding LDL receptor gene family.
Statin-induced Krüppel-like factor 2 expression in human and mouse T cells reduces inflammatory and pathogenic responses.
It is concluded that statins reduce inflammatory functions and pathogenic activity of T cells through KLF2-dependent mechanisms, and this pathway may be a potential therapeutic target for cardiovascular diseases.
Verruculides A and B, two new protein tyrosine phosphatase 1B inhibitors from an Indonesian ascidian-derived Penicillium verruculosum.
New rugulosins, anti-MRSA antibiotics, produced by Penicillium radicum FKI-3765-2.
Rugulosin A to C showed antimicrobial activity against methicillin-resistant Staphylococcus aureus and new rugulosins B and C were a homodimer of the same anthraquinone moieties.
Differential expression of LR11 during proliferation and differentiation of cultured neuroblastoma cells.
The transcription of LR11 in these two cell systems is regulated differently during proliferation and differentiation, suggesting that the multifunctionality ofLR11, as well as other LDLR family members, for rapid cell growth in malignant cells and neural outgrowth in cultured neurons, respectively.
Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders
- D. Fukuda, E. Aikawa, M. Aikawa
- Biology, MedicineProceedings of the National Academy of Sciences
- 13 June 2012
Blockade of Dll4-Notch signaling using neutralizing anti-Dll4 antibody attenuated the development of atherosclerosis, diminished plaque calcification, improved insulin resistance, and decreased fat accumulation, suggesting that Dll3- notch signaling plays a central role in the shared mechanism for the pathogenesis of cardiometabolic disorders.
LR11, an LDL Receptor Gene Family Member, Is a Novel Regulator of Smooth Muscle Cell Migration
The novel mechanism of regulation of uPAR localization in SMCs accompanied with enhanced migration activity possibly constitutes an important factor in the process of atherosclerosis and arterial remodeling.
Effect of pitavastatin on apolipoprotein A-I production in HepG2 cell.
A dimeric urea of the bisabolene sesquiterpene from the Okinawan marine sponge Axinyssa sp. inhibits protein tyrosine phosphatase 1B activity in Huh-7 human hepatoma cells.
A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins.
The dominant effects of the CETP missense mutation during cellular expression probably explains why the probands have markedly increased HDL in the heterozygous state, and suggests that the active molecular species of CETP may be multimeric.