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polyketide synthase

Known as: Polyketide Synthases, PKS enzyme, Polyketide Synthases [Chemical/Ingredient] 
Large enzyme complexes composed of a number of component enzymes that are found in STREPTOMYCES which biosynthesize MACROLIDES and other polyketides.
National Institutes of Health

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Related topics

17 relations

Narrower (8)

1,3,6,8-tetrahydroxynaphthalene synthase, Streptomyces coelicolor6-Deoxyerythronolide-B SynthasePKS15 protein, Mycobacterium tuberculosis H37RvPolyketide Synthase WA
Fatty-acid synthaseIn BloodProcess of secretionantagonists & inhibitors

Broader (1)

Multienzyme Complexes

Papers overview

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Highly Cited
2008
Highly Cited
2008
Rh-catalyzed carbonyl hydroacylation: an enantioselective approach to lactones.
This communication describes the design and execution of a novel approach to forming chiral lactones via C−H bond activation. The… 
Highly Cited
2006
Highly Cited
2006
Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56.
Highly Cited
2006
Highly Cited
2006
Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining.
Polyketide synthases (PKSs) are involved in the biosynthesis of many important natural products. In bacteria, type III PKSs… 
Highly Cited
2004
Highly Cited
2004
Chalcomycin Biosynthesis Gene Cluster from Streptomyces bikiniensis: Novel Features of an Unusual Ketolide Produced through Expression of the chm Polyketide Synthase in Streptomyces fradiae
ABSTRACT Chalcomycin, a 16-membered macrolide antibiotic made by the bacterium Streptomyces bikiniensis, contains a 2,3-trans… 
Highly Cited
2002
Highly Cited
2002
Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26.
Review
2001
Review
2001
Nitrogen-containing metabolites from marine cyanobacteria.
Highly Cited
2001
Highly Cited
2001
Identification of Claisen cyclase domain in fungal polyketide synthase WA, a naphthopyrone synthase of Aspergillus nidulans.
Highly Cited
1999
Highly Cited
1999
The first gene in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus codes for a unique PKS module coupled to a peptide synthetase.
The polyketide antibiotic TA is synthesized by the Gram negative bacterium Myxococcus xanthus in a multi-step process in which a… 
Highly Cited
1995
Highly Cited
1995
Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2)
The multifunctional 6-methylsalicylic acid synthase gene from Penicillium patulum was engineered for regulated expression in… 
Highly Cited
1995
Highly Cited
1995
Characterization of the polyketide synthase gene (pksL1) required for aflatoxin biosynthesis in Aspergillus parasiticus
Aflatoxins are potent toxic and carcinogenic compounds, produced by Aspergillus parasiticus and A. flavus as secondary… 
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