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polyketide synthase

Known as: Polyketide Synthases, PKS enzyme, Polyketide Synthases [Chemical/Ingredient] 
Large enzyme complexes composed of a number of component enzymes that are found in STREPTOMYCES which biosynthesize MACROLIDES and other polyketides.
National Institutes of Health

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Narrower (8)

1,3,6,8-tetrahydroxynaphthalene synthase, Streptomyces coelicolor6-Deoxyerythronolide-B SynthasePKS15 protein, Mycobacterium tuberculosis H37RvPolyketide Synthase WA
Fatty-acid synthaseIn BloodProcess of secretionantagonists & inhibitors

Broader (1)

Multienzyme Complexes

Papers overview

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Highly Cited
2011
Highly Cited
2011
Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulans.
An StcA-AfoE hybrid polyketide synthase (PKS), generated by swapping the AfoE (asperfuranone biosynthesis) SAT domain with the… 
Highly Cited
2009
Highly Cited
2009
The biochemical basis for stereochemical control in polyketide biosynthesis.
One of the most striking features of complex polyketides is the presence of numerous methyl- and hydroxyl-bearing stereogenic… 
Highly Cited
2007
Highly Cited
2007
An acridone‐producing novel multifunctional type III polyketide synthase from Huperzia serrata
A cDNA encoding a novel plant type III polyketide synthase was cloned and sequenced from the Chinese club moss Huperzia serrata… 
Highly Cited
2006
Highly Cited
2006
Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56.
Highly Cited
2004
Highly Cited
2004
Chalcomycin Biosynthesis Gene Cluster from Streptomyces bikiniensis: Novel Features of an Unusual Ketolide Produced through Expression of the chm Polyketide Synthase in Streptomyces fradiae
ABSTRACT Chalcomycin, a 16-membered macrolide antibiotic made by the bacterium Streptomyces bikiniensis, contains a 2,3-trans… 
Highly Cited
2002
Highly Cited
2002
Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26.
Review
2001
Review
2001
Nitrogen-containing metabolites from marine cyanobacteria.
Highly Cited
1999
Highly Cited
1999
The first gene in the biosynthesis of the polyketide antibiotic TA of Myxococcus xanthus codes for a unique PKS module coupled to a peptide synthetase.
The polyketide antibiotic TA is synthesized by the Gram negative bacterium Myxococcus xanthus in a multi-step process in which a… 
Highly Cited
1995
Highly Cited
1995
Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2)
The multifunctional 6-methylsalicylic acid synthase gene from Penicillium patulum was engineered for regulated expression in… 
Highly Cited
1992
Highly Cited
1992
6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.
Sequencing of the eryA region of the erythromycin biosynthetic gene cluster from Saccharopolyspora erythraea has revealed another… 
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