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Engineered biosynthesis of plant polyketides: chain length control in an octaketide-producing plant type III polyketide synthase.
The functional diversity of the type III PKS was shown to evolve from simple steric modulation of the chemically inert single residue lining the active-site cavity accompanied by conservation of the Cys-His-Asn catalytic triad, providing novel strategies for the engineered biosynthesis of pharmaceutically important plant polyketides.
Benzalacetone synthase. A novel polyketide synthase that plays a crucial role in the biosynthesis of phenylbutanones in Rheum palmatum.
Besides the phenylbutanones in rhubarb, BAS has been proposed to play a crucial role for the construction of the C6-C4 moiety of a variety of natural products such as medicinally important gingerols in ginger plant.
Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases.
Covering: 2002 to 2009 This review covers recent advances in structure and function studies on the chalcone synthase (CHS) superfamily of plant type III polyketide synthases (PKSs), which catalyze
An environmental bacterial taxon with a large and distinct metabolic repertoire
Two phylotypes of the candidate genus ‘Entotheonella’ with genomes of greater than 9 megabases and multiple, distinct biosynthetic gene clusters co-inhabit the chemically and microbially rich marine sponge Theonella swinhoei.
Enzymatic synthesis of cyclic triterpenes.
  • I. Abe
  • Chemistry
    Natural product reports
  • 21 November 2007
Recent crystallographic and structure-based mutagenesis studies as well as utilization of chemically synthesized active-site probes have begun to reveal intimate structural details of the enzyme-templated cyclization reactions.
Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat.
Cataract onset was associated with the specific combination of Lss and Fdft1 mutant alleles that decreased cholesterol levels in cataractous lenses to about 57% of normal, suggesting cholesterol insufficiency may underlie the deficient proliferation of lens epithelial cells in SCRs, which results in the loss of homeostatic epithelial cell control of the underlying fiber cells and eventually leads to cataracts.
Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus
The in vivo activity of F-acids is reported, confirming that the lipid extract of the green-lipped mussel includes an unstable fatty acid that is more effective than EPA.