Complete genome sequence of the myxobacterium Sorangium cellulosum
- S. Schneiker, O. Perlova, R. Müller
- Biology, EngineeringNature Biotechnology
- 1 November 2007
The complete genome sequence of the model Sorangium strain S. cellulosum So ce56 is reported, which produces several natural products and has morphological and physiological properties typical of the genus, and the circular genome is the largest bacterial genome sequenced to date.
Myxobacteria: proficient producers of novel natural products with various biological activities--past and future biotechnological aspects with the focus on the genus Sorangium.
- K. Gerth, S. Pradella, O. Perlova, S. Beyer, R. Müller
- Biology, EngineeringJournal of Biotechnology
- 19 December 2003
Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties.
- K. Gerth, N. Bedorf, G. Höfle, H. Irschik, H. Reichenbach
- BiologyJournal of antibiotics (Tokyo. )
- 25 June 1996
An antifungal activity against Mucor hiemalis was detected in the culture broth of Sorangium cellulosum strain So ce90 and the epothilons showed a high cytotoxicity for animal cells and mimic the biological effects of taxol.
Expanded phylogeny of myxobacteria and evidence for cultivation of the 'unculturables'.
- Ronald Garcia, K. Gerth, M. Stadler, I. Dogma, R. Müller
- BiologyMolecular Phylogenetics and Evolution
- 1 November 2010
Characterisation, genome size and genetic manipulation of the myxobacterium Sorangium cellulosum So ce56
- S. Pradella, A. Hans, C. Spröer, H. Reichenbach, K. Gerth, S. Beyer
- Biology, EngineeringArchives of Microbiology
- 1 October 2002
S. cellulosum So ce56 was phenotypically and genotypically analysed in order to evaluate whether this strain can be used in a comprehensive genome project as a representative of the secondary metabolite-producing myxobacteria, and was found to have various advantageous features.
The corallopyronins, new inhibitors of bacterial RNA synthesis from Myxobacteria.
- H. Irschik, R. Jansen, G. Höfle, K. Gerth, H. Reichenbach
- Biology, ChemistryJournal of antibiotics (Tokyo. )
- 1 February 1985
Three new antibiotics have been isolated from the culture broth of the myxobacterium, Corallococcus (Myxococcus) coralloides, and appear to block specifically eubacterial RNA polymerase.
Ratjadones inhibit nuclear export by blocking CRM1/exportin 1.
- M. Köster, Søren Lykke-Andersen, H. Hauser
- BiologyExperimental Cell Research
- 10 June 2003
New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies.
- Ingo H. Hardt, H. Steinmetz, K. Gerth, F. Sasse, H. Reichenbach, G. Höfle
- Chemistry, BiologyJournal of Natural Products
- 8 June 2001
The structures of the new epothilones were elucidated on the basis of comprehensive NMR and MS data and are presumably the result of the imperfect selectivity of the biosynthetic enzymes for acetate and propionate.
Bacterial type III polyketide synthases: phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in pseudomonads
The successful heterologous production of a secondary metabolite using a gene not expressed under administered laboratory conditions provides evidence for the usefulness of the approach to activate suchsecondary metabolite genes for the production of novel metabolites.
Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria
- Thomas Hoffmann, D. Krug, R. Müller
- BiologyNature Communications
- 23 February 2018
A systematic metabolite survey of over 2300 myxobacterial strains of the order Myxococcales finds a correlation between taxonomic distance and production of distinct secondary metabolite families, further supporting the idea that the chances of discovering novel metabolites are greater by examining strains from new genera rather than additional representatives within the same genus.
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