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Fatty-acid synthase

Known as: FAS, FASN, EC 2.3.1.85 
Fatty acid synthase (2511 aa, ~273 kDa) is encoded by the human FASN gene. This protein is involved in long-chain fatty acid synthesis.
National Institutes of Health

Related topics

Related topics

16 relations

Narrower (1)

Acyl Carrier Protein

Broader (2)

AcyltransferaseFatty Acid Synthases
Enzyme GeneEsterase GeneFASN geneFASN wt Allele

Papers overview

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Highly Cited
2002
Highly Cited
2002
Generation and Characterization of Smac/DIABLO-Deficient Mice
ABSTRACT The mitochondrial proapoptotic protein Smac/DIABLO has recently been shown to potentiate apoptosis by counteracting the… 
Highly Cited
2001
Highly Cited
2001
Glutamine-dependent Antiapoptotic Interaction of Human Glutaminyl-tRNA Synthetase with Apoptosis Signal-regulating Kinase 1*
Glutamine has been known to be an apoptosis suppressor, since it blocks apoptosis induced by heat shock, irradiation, and c-Myc… 
Highly Cited
2000
Highly Cited
2000
The Fas-induced Apoptosis Analyzed by High Throughput Proteome Analysis*
The fate of cytosolic proteins was studied during Fas-induced cell death of Jurkat T-lymphocytes by proteome analysis. Among 1000… 
Highly Cited
2000
Highly Cited
2000
Involvement of Sphingosine in Mitochondria-dependent Fas-induced Apoptosis of Type II Jurkat T Cells*
Exposure to anti-Fas antibody in Jurkat cells (type II cells), which are characterized by a weak caspase-8 activation at the… 
Highly Cited
1999
Highly Cited
1999
Flice-Inhibitory Protein Expression during Macrophage Differentiation Confers Resistance to FAS-Mediated Apoptosis
Macrophages differentiated from circulating peripheral blood monocytes are essential for host immune responses and have been… 
Highly Cited
1998
Highly Cited
1998
APO2 ligand: a novel lethal weapon against malignant glioma?
Highly Cited
1997
Highly Cited
1997
Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T cell survival and proliferation.
Activation of T cells is induced efficiently by dendritic cells (DC), but little is known about the role of DC in the regulation… 
Highly Cited
1997
Highly Cited
1997
Monocytes express Fas ligand upon CD4 cross-linking and induce CD4+ T cells apoptosis: a possible mechanism of bystander cell death in HIV infection.
Recent evidence indicates that death of uninfected lymphocytes by apoptosis plays an important role in the immunopathogenesis of… 
Highly Cited
1996
Highly Cited
1996
Elevated soluble Fas (sFas) levels in nonhematopoietic human malignancy.
Fas is a widely expressed membrane-anchored protein that induces apoptosis. Soluble Fas (sFas), generated by alternative mRNA… 
Highly Cited
1995
Highly Cited
1995
TCR/CD3 coupling to Fas-based cytotoxicity
We studied the coupling of the TCR/CD3 complex to a T cell effector function, namely Fas-based T-cell-mediated cytotoxicity… 
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