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Fatty-acid synthase

Known as: FAS, FASN, EC 2.3.1.85 
Fatty acid synthase (2511 aa, ~273 kDa) is encoded by the human FASN gene. This protein is involved in long-chain fatty acid synthesis.
National Institutes of Health

Papers overview

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Review
2017
Review
2017
In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been the object of intensive research. miRNAs… Expand
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Review
2017
Review
2017
Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes, playing detrimental roles in the… Expand
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Review
2017
Review
2017
Among various factors, such as an unhealthy diet or a sedentarity lifestyle, excessive fructose consumption is known to favor… Expand
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Review
2017
Review
2017
One of the most important metabolic hallmarks of cancer cells is deregulation of lipid metabolism. In addition, enhancing de novo… Expand
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Review
2013
Review
2013
Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a common feature of all cancers, requires… Expand
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Review
2007
Review
2007
There is a renewed interest in the ultimate role of fatty acid synthase (FASN) — a key lipogenic enzyme catalysing the terminal… Expand
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Highly Cited
2005
Highly Cited
2005
Endogenous cannabinoids acting at CB(1) receptors stimulate appetite, and CB(1) antagonists show promise in the treatment of… Expand
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Highly Cited
2000
Highly Cited
2000
With the escalation of obesity-related disease, there is great interest in defining the mechanisms that control appetite and body… Expand
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Highly Cited
1996
Highly Cited
1996
To identify CAP3 and CAP4, components of the CD95 (Fas/APO-1) death-inducing signaling complex, we utilized nano-electrospray… Expand
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Review
1995
Review
1995
Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus… Expand
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