Fatty-acid synthase

Known as: FAS, FASN, EC 2.3.1.85 
Fatty acid synthase (2511 aa, ~273 kDa) is encoded by the human FASN gene. This protein is involved in long-chain fatty acid synthesis.

Topic mentions per year

Topic mentions per year

1975-2017
020040060019752017

Papers overview

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Highly Cited
2005
Highly Cited
2005
Endogenous cannabinoids acting at CB(1) receptors stimulate appetite, and CB(1) antagonists show promise in the treatment of… (More)
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Highly Cited
2004
Highly Cited
2004
One of the fundamental principles of pharmacology is that most drugs have side effects. Although considerable attention is paid… (More)
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Highly Cited
2004
Highly Cited
2004
Cellular levels of key regulatory proteins are controlled via ubiquitination and subsequent degradation. Deubiquitinating enzymes… (More)
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Highly Cited
2003
Highly Cited
2003
Adiponectin has recently been shown to be a promising candidate for the treatment of obesity-associated metabolic syndromes… (More)
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Highly Cited
2002
Highly Cited
2002
The nuclear receptors LXRalpha and LXRbeta have been implicated in the control of lipogenesis and cholesterol homeostasis. Ligand… (More)
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Highly Cited
2000
Highly Cited
2000
With the escalation of obesity-related disease, there is great interest in defining the mechanisms that control appetite and body… (More)
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Highly Cited
2000
Highly Cited
2000
Compared to normal human tissues, many common human cancers, including carcinoma of the colon, prostate, ovary, breast, and… (More)
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Highly Cited
1996
Highly Cited
1996
The NH2-terminal domain of sterol-regulatory element binding protein-1a (SREBP-1a) activates transcription of genes encoding… (More)
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Highly Cited
1996
Highly Cited
1996
Adipocyte determination and differentiation-dependent factor 1 (ADD1) is a member of the basic helix-loop-helix leucine zipper… (More)
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Highly Cited
1994
Highly Cited
1994
OA-519 is a prognostic molecule found in tumor cells from breast cancer patients with markedly worsened prognosis. We purified OA… (More)
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