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FASN gene

Known as: Fatty Acid Synthase Gene, FAS, SDR27X1 
This gene is involved in the production of both lung surfactant and the fatty components of milk. It also plays a role in the conversion and storage… 
National Institutes of Health

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FASN wt Allele
Fatty Acid SynthasesFatty-acid synthaseHydrolysisOxidation-Reduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Chronic Mild Cold Conditioning Modulates the Expression of Hypothalamic Neuropeptide and Intermediary Metabolic-Related Genes and Improves Growth Performances in Young Chicks
Background Low environmental temperatures are among the most challenging stressors in poultry industries. Although landmark… 
Highly Cited
2006
Highly Cited
2006
Pu-erh tea supplementation suppresses fatty acid synthase expression in the rat liver through downregulating Akt and JNK signalings as demonstrated in human hepatoma HepG2 cells.
Fatty acid synthase (FAS) is a key enzyme of lipogenesis. Overexpression of FAS is dominant in cancer cells and proliferative… 
Highly Cited
2003
Highly Cited
2003
Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas.
PURPOSE Fatty acid synthase (FAS) is a key enzyme in the de novo biosynthesis of fatty acids. Carcinoma cells are dependent on… 
Highly Cited
2002
Highly Cited
2002
Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion.
Mice respond to fatty acid synthase (FAS) inhibitors by profoundly reducing their food intake and body weight. Evidence indicates… 
Highly Cited
2002
Highly Cited
2002
Domain movements in human fatty acid synthase by quantized elastic deformational model
This paper reports the results of applying a computational method called the quantized elastic deformational model, to the… 
Highly Cited
2001
Highly Cited
2001
Transcriptional regulation of fatty acid synthase gene by insulin/glucose, polyunsaturated fatty acid and leptin in hepatocytes and adipocytes in normal and genetically obese rats.
Transcriptional regulation of the fatty acid synthase (FAS) gene by insulin/glucose, polyunsaturated fatty acids and leptin was… 
Highly Cited
1998
Highly Cited
1998
Plasma lipids and fatty acid synthase activity are regulated by short-chain fructo-oligosaccharides in sucrose-fed insulin-resistant rats.
The aim of this study was to evaluate the chronic effects of a short-chain fructo-oligosaccharide (FOS)-containing diet on plasma… 
Highly Cited
1996
Highly Cited
1996
Identification of an Inverted CCAAT Box Motif in the Fatty-acid Synthase Gene as an Essential Element for Mediation of Transcriptional Regulation by cAMP (*)
The antagonistic effect of cAMP on the insulin-induced expression of fatty acid synthase (FAS) in liver could be mimicked in… 
Highly Cited
1993
Highly Cited
1993
Regulation of fatty acid synthase gene transcription. Sequences that confer a positive insulin effect and differentiation-dependent expression in 3T3-L1 preadipocytes are present in the 332 bp…
We have previously reported induction of fatty acid synthase (FAS) gene expression by insulin and adipocyte differentiation in… 
Highly Cited
1989
Highly Cited
1989
Molecular cloning and sequencing of chicken liver fatty acid synthase cDNA.
The complete amino acid sequence of chicken liver fatty acid synthase [acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating… 
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