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Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess liver triacylglycerol (TAG), inflammation, and liver damage. The goal of the present study was to directlyExpand
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Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease.
BACKGROUND & AIMS There have been few studies of the role of de novo lipogenesis in the development of nonalcoholic fatty liver disease (NAFLD). We used isotope analyses to compare de novoExpand
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Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease.
Approximately one-third of the U.S. population has nonalcoholic fatty liver disease (NAFLD), a condition closely associated with insulin resistance and increased risk of liver injury. DysregulatedExpand
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Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms.
Current trends in health promotion emphasize the importance of reducing dietary fat intake. However, as dietary fat is reduced, the dietary carbohydrate content typically rises and the desiredExpand
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Temporal pattern of de novo lipogenesis in the postprandial state in healthy men.
BACKGROUND Recent data suggest that hepatic de novo lipogenesis (DNL) is elevated in the fed state compared with the fasting state, but the rate at which lipogenesis can increase with mealExpand
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Dietary sugars stimulate fatty acid synthesis in adults.
The goal of this study was to determine the magnitude by which acute consumption of fructose in a morning bolus would stimulate lipogenesis (measured by infusion of 13C1-acetate and analysis byExpand
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Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states.
CONTEXT The liver's regulation of fatty acids (FAs) postprandially may contribute to risk of metabolic diseases. OBJECTIVE Measurements of steady-state metabolism were used to investigate sourcesExpand
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Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance.
Low-fat, high-carbohydrate (LF/HC) diets commonly elevate plasma triglyceride (TG) concentrations, but the kinetic mechanisms responsible for this effect remain uncertain. Subjects with low TGExpand
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Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure
OBJECTIVE We evaluate a potential role of activating transcription factor 4 (Atf4) in invertebrate and mammalian metabolism. RESEARCH DESIGN AND METHODS With two parallel approaches—a fatExpand
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Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
Mitochondria are critical for respiration in all tissues; however, in liver, these organelles also accommodate high-capacity anaplerotic/cataplerotic pathways that are essential to gluconeogenesisExpand
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