Skip to search formSkip to main contentSkip to account menu

oncoprotein p21

Known as: MDA 6, WAF-1 Protein, CDK2 Associated Protein 20 kDa 
A cyclin-dependent kinase inhibitor that mediates TUMOR SUPPRESSOR PROTEIN P53-dependent CELL CYCLE arrest. p21 interacts with a range of CYCLIN… 
National Institutes of Health

Related topics

Related topics

34 relations
ATM Signaling PathwayCDKN1A geneCDKN1A wt AlleleCalcineurin Pathway

Narrower (1)

Cdkn1a protein, rat

Broader (4)

Cell Cycle ProteinsEnzyme InhibitorsProtein Kinase InhibitorsProtein Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
p21Waf1/Cip1/Sdi1 mediates retinoblastoma protein degradation
Damage-induced G1 checkpoint in mammalian cells involves upregulation of p53, which activates transcription of p21Waf1 (CDKN1A… 
Highly Cited
2007
Highly Cited
2007
In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma
Kruppel-like factor (KLF) 6 is a tumor-suppressor gene functionally inactivated by loss of heterozygosity, somatic mutation and… 
Highly Cited
2005
Highly Cited
2005
Saururus cernuus lignans--potent small molecule inhibitors of hypoxia-inducible factor-1.
Highly Cited
2004
Highly Cited
2004
Up-regulation of p21 Gene Expression by Peroxisome Proliferator-Activated Receptor γ in Human Lung Carcinoma Cells
Purpose: The peroxisome proliferator-activated receptor γ (PPARγ), a ligand-dependent transcription factor belonging to the… 
Highly Cited
2001
Highly Cited
2001
Induction of a Senescence-Like Phenotype in Bovine Aortic Endothelial Cells by Ionizing Radiation
Abstract Oh, C-W., Bump, E. A., Kim, J-S., Janigro, D. and Mayberg, M. R. Induction of a Senescence-Like Phenotype in Bovine… 
Highly Cited
2001
Highly Cited
2001
A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function
The tumor suppressor p53 is an inducer of cell cycle arrest and programmed cell death (apoptosis). The ability of p53 to induce… 
Highly Cited
1998
Highly Cited
1998
Constitutive Expression of the Cyclin-dependent Kinase Inhibitor p21 Is Transcriptionally Regulated by the Tumor Suppressor Protein p53*
The tumor suppressor protein p53 has been implicated in the response of cells to DNA damage. Studies to date have demonstrated a… 
Highly Cited
1997
Highly Cited
1997
Involvement of the Sp3 Transcription Factor in Induction of p21Cip1/WAF1 in Keratinocyte Differentiation*
The cyclin-dependent kinase inhibitor p21 is induced in several in vitro terminal differentiation systems as well as in… 
Highly Cited
1997
Highly Cited
1997
Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: involvement of cyclin-dependent kinase inhibitor p21 in polyploidization.
The mechanism of megakaryocytic differentiation was investigated using human megakaryocytic leukemia cell line UT-7… 
Highly Cited
1980
Highly Cited
1980
Comparative heterokaryon study of cellular senescence and the serum-deprived state.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)