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The role of secondary brain injury in determining outcome from severe head injury.
The increased morbidity and mortality related to severe trauma to an extracranial organ system appeared primarily attributable to associated hypotension, and improvements in trauma care delivery over the past decade have not markedly altered the adverse influence of hypotension.
A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study.
It is concluded that in patients with acute spinal-cord injury, treatment with methylprednisolone in the dose used in this study improves neurologic recovery when the medication is given in the first eight hours.
A new classification of head injury based on computerized tomography
✓ A new classification of head injury based primarily on information gleaned from the initial computerized tomography (CT) scan is described. It utilizes the status of the mesencephalic cisterns, the
The diagnosis of head injury requires a classification based on computed axial tomography.
A new classification scheme to be used both as a research and a clinical tool in association with other predictors of neurologic status is described.
Choline and Selective Antagonists Identify Two Subtypes of Nicotinic Acetylcholine Receptors that Modulate GABA Release from CA1 Interneurons in Rat Hippocampal Slices
It is demonstrated that CA1 interneurons, in addition to expressing functional α7 nA ChRs, also express functional α4β2-like nAChRs and that activation of both receptors facilitates an action potential-dependent release of GABA.
The neurobehavioural rating scale: assessment of the behavioural sequelae of head injury by the clinician.
  • H. Levin, W. High, H. Gary
  • Psychology, Medicine
    Journal of neurology, neurosurgery, and…
  • 1 February 1987
Although the findings provide support for utilising clinical ratings of behaviour to investigate sequelae of head injury, extension of this technique to other settings is necessary to evaluate the distinctiveness of the neurobehavioural profile of closed head injury as compared with other aetiologies of brain damage.
Impact of ICP instability and hypotension on outcome in patients with severe head trauma
The relationship between raised intracranial pressure (ICP), hypotension, and outcome from severe head injury is described and a stepwise ordinal logistic regression was used to determine outcome.
Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study.
Treatment with the study dose of methylprednisolone is indicated for acute spinal cord trauma, but only if it can be started within 8 hours of injury.
Outcome following decompressive craniectomy for malignant swelling due to severe head injury.
Decompressive craniectomy was associated with a better-than-expected functional outcome in patients with medically uncontrollable ICP and/or brain herniation, compared with outcomes in other control cohorts reported on in the literature.
Neurobehavioral outcome following minor head injury: a three-center study.
The data suggest that a single uncomplicated minor head injury produces no permanent disabling neurobehavioral impairment in the great majority of patients who are free of preexisting neuropsychiatric disorder and substance abuse.