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midostaurin

Known as: N-Benzoyl-Staurosporine, 4'-N-benzoylstaurosporine, N-((9S,10R,11R,13R)-10-methoxy-9-methyl-1-oxo-2,3,10,11,12,13-hexahydro-9,13-epoxy-1H,9H-diindolo(1,2,3-GH:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-n-methylbenzamide 
A synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. Midostaurin inhibits protein kinase C… 
National Institutes of Health

Related topics

Related topics

14 relations

Broader (4)

AlkaloidsAntineoplastic AgentsProtein Kinase InhibitorsStaurosporine

Narrower (3)

CGP 41251CGP41251PKC412
FLT3 protein, humanMast/Stem Cell Growth Factor Receptor Kit, humanNCIt Antineoplastic Agent TerminologyPlatelet-Derived Growth Factor Receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
The pan‐Bcl‐2 blocker obatoclax promotes the expression of Puma, Noxa, and Bim mRNA and induces apoptosis in neoplastic mast cells
Advanced SM is an incurable neoplasm with short survival time. So far, no effective therapy is available for these patients. We… 
Highly Cited
2008
Highly Cited
2008
Peptide biosensors for the electrochemical measurement of protein kinase activity.
The kinase activities are elucidated using the novel redox-active cosubstrate adenosine 5'-[gamma-ferrocene] triphosphate (Fc-ATP… 
Review
2007
Review
2007
The therapeutic role of targeting protein kinase C in solid and hematologic malignancies
The protein kinase C (PKC) family, the most prominent target of tumor-promoting phorbol esters, is functionally linked to cell… 
Highly Cited
2001
Highly Cited
2001
Differential p53-dependent mechanism of radiosensitization in vitro and in vivo by the protein kinase C-specific inhibitor PKC412.
The cellular response to ionizing radiation is governed by the DNA-damage recognition process but is also modulated by… 
1997
1997
Analysis of Drug/Plasma Protein Interactions by Means of Asymmetrical Flow Field-Flow Fractionation
AbstractPurpose. The applicability of Asymmetrical Flow Field-Flow Fractionation (Asymmetrical Flow FFF) as an alternative tool… 
1996
1996
Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells.
The antitumor effect of CGP41251 (4'-N-benzoyl staurosporine), a selective protein kinase C (PKC) inhibitor, was examined on two… 
1996
1996
Effects of the new selective protein kinase C inhibitor 4'-N-benzoyl staurosporine on cell cycle distribution and growth inhibition in human small cell lung cancer cells.
CGP 41251 (4'-N-benzoyl staurosporine, CAS 120685-11-2) exerts increased selectivity for Ca(2+)- and phospholipid-dependent… 
1995
1995
Analytical procedure for the determination of the new antitumour drug N-benzoylstaurosporine and three potential metabolites in human plasma by reversed-phase high-performance liquid chromatography.
1995
1995
Antitumor activity of the new selective protein kinase C inhibitor 4'-N-benzoyl staurosporine on murine and human tumor models.
CGP 41251 (4'-N-benzoyl staurosporine, CAS 120685-11-2) has been shown to exert increased selectivity for the inhibition of… 
Highly Cited
1988
Highly Cited
1988
Staurosporine, a novel protein kinase inhibitor, enhances HL-60-cell differentiation induced by various compounds.
The effect of staurosporine, a novel calcium/phospholipid-dependent protein kinase (protein kinase C) inhibitor, on… 
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