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midostaurin

Known as: N-Benzoyl-Staurosporine, 4'-N-benzoylstaurosporine, N-((9S,10R,11R,13R)-10-methoxy-9-methyl-1-oxo-2,3,10,11,12,13-hexahydro-9,13-epoxy-1H,9H-diindolo(1,2,3-GH:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-11-yl)-n-methylbenzamide 
A synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. Midostaurin inhibits protein kinase C… 
National Institutes of Health

Related topics

Related topics

14 relations

Broader (4)

AlkaloidsAntineoplastic AgentsProtein Kinase InhibitorsStaurosporine

Narrower (3)

CGP 41251CGP41251PKC412
FLT3 protein, humanMast/Stem Cell Growth Factor Receptor Kit, humanNCIt Antineoplastic Agent TerminologyPlatelet-Derived Growth Factor Receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Management of Midostaurin-CYP3A4 Drug-Drug Interactions in Patients With Acute Myeloid Leukemia.
This article summarizes available data for the use of CYP3A4 inhibitors with midostaurin for acute myeloid leukemia. 
2017
2017
A United States Patent ( 19 ) 11 Patent Number : 5 , 344 , 926 Murakata et al . 45 Date of Patent : Sep . 6 , 1994 54 PROCESS FOR PRODUCING
54 PROCESS FOR PRODUCING STAUROSPORINE DERVATIVES OTHER PUBLICATIONS Takahashi et al. J. Antibiotics, Dec. 1987, pp. 75 Inventors… 
2014
2014
Compassionate Use of Midostaurin in Myeloid and Lymphoid Neoplasia with FGFR1 Abnormality
Background: Patients with stem cell myeloproliferative disorders have a particularly poor prognosis and limited treatment options… 
2014
2014
PKC412 (midostaurin) is safe and highly effective in systemic mastocytosis: Follow up of a single-center Italian compassionate use.
7113 Background: Treatment of SM usually focuses on symptom relief by histamine receptor antagonists and other supportive therapy… 
2014
2014
Abstract 746: PKC412 (Midostaurin) is safe and highly effective in systemic mastocytosis patients: Follow up of a single-center Italian compassionate use
Introduction. Mastocytosis is a myeloid neoplasm characterized by abnormal accumulation and frequent activation of mast cells… 
2013
2013
FLT 3 Inhibitors for the Treatment of Acute Myeloid Leukemia
634. 42. Hexner EO, Serdikoff C, Jan M, et al. Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and… 
2011
2011
Abstracts presented at the ESVONC Annual Congress, Turin, Italy, 18-20 March 2010.
2009
2009
Indolocarbazoles glycosylés, leur procédé d'obtention et leurs utilisations
Cette invention concerne des derives de rebecamicine et de staurosporine obtenus par la fermentation de souches bacteriennes… 
2006
2006
Antitumor Effect of CGP 41251 , a New Selective Protein Kinase C Inhibitor , on Human Non-Small Cell Lung Cancer Cells
The antitumor effect of CGP41251 (4'-N-benzoyl staurosporine), a selective protein kinase C (PKC) inhibitor, was examined on two… 
1988
1988
N-substituted staurosporine derivatives and salts thereof, process for their preparation, pharmaceutical composition containing them and the use of the N-substituted staurosporine derivatives for the…