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Platelet-Derived Growth Factor Receptor

Known as: Platelet Derived Growth Factor Receptors, Receptor, PDGF, Receptors, Platelet-Derived Growth Factor 
Specific receptors on cell membranes that react with PLATELET-DERIVED GROWTH FACTOR, its analogs, or antagonists. The alpha PDGF receptor (RECEPTOR… Expand
National Institutes of Health

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Related topics

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Cell Proliferation Regulatory ProcessCrenolanib BesylateDovitinib LactateImatinib mesylate
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PDGFRL protein, human

Papers overview

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Review
2018
Review
2018
Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development
Anlotinib is a new, orally administered tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR… Expand
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Review
2018
Review
2018
The PDGF/PDGFR pathway as a drug target.
Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration, primarily of cells of mesenchymal… Expand
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Highly Cited
2008
Highly Cited
2008
Sorafenib in advanced hepatocellular carcinoma.
BACKGROUND No effective systemic therapy exists for patients with advanced hepatocellular carcinoma. A preliminary study… Expand
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Highly Cited
2006
Highly Cited
2006
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma.
PURPOSE Renal cell carcinoma (RCC) is characterized by loss of von Hippel Lindau tumor suppressor gene activity, resulting in… Expand
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Highly Cited
2005
Highly Cited
2005
Aptamer-modified gold nanoparticles for colorimetric determination of platelet-derived growth factors and their receptors.
We have developed a highly specific sensing system for platelet-derived growth factors (PDGFs) and platelet-derived growth factor… Expand
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Highly Cited
2003
Highly Cited
2003
SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer.
The purpose of this study was to evaluate the activity of the indolinone kinase inhibitor SU11248 against the receptor tyrosine… Expand
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Highly Cited
2003
Highly Cited
2003
PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors
Most gastrointestinal stromal tumors (GISTs) have activating mutations in the KIT receptor tyrosine kinase, and most patients… Expand
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Review
1998
Review
1998
Signal transduction via platelet-derived growth factor receptors.
Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility by binding to two related… Expand
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Highly Cited
1992
Highly Cited
1992
Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors.
Analysis of genomic organization and expression of platelet-derived growth factor receptors (PDGFR) and epidermal growth factor… Expand
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Review
1989
Review
1989
Signal transduction by the platelet-derived growth factor receptor.
When platelet-derived growth factor (PDGF) binds to its receptor on a quiescent fibroblast or smooth muscle cell, it stimulates a… Expand
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