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Platelet-Derived Growth Factor Receptor

Known as: Platelet Derived Growth Factor Receptors, Receptor, PDGF, Receptors, Platelet-Derived Growth Factor 
Specific receptors on cell membranes that react with PLATELET-DERIVED GROWTH FACTOR, its analogs, or antagonists. The alpha PDGF receptor (RECEPTOR… 
National Institutes of Health

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Cell Proliferation Regulatory ProcessCrenolanib BesylateDovitinib LactateImatinib mesylate

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PDGFRL protein, human

Papers overview

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Highly Cited
2006
Highly Cited
2006
Autocrine/paracrine platelet-derived growth factor regulates proliferation of neural progenitor cells.
Growth factors play an important role in regulating neural stem cell proliferation and differentiation. This study shows that… 
Highly Cited
2003
Highly Cited
2003
SU 11248 Inhibits KIT and Platelet-derived Growth Factor Receptor in Preclinical Models of Human Small Cell Lung Cancer
The purpose of this study was to evaluate the activity of the indolinone kinase inhibitor SU11248 against the receptor tyrosine… 
Highly Cited
1998
Highly Cited
1998
Activation of Src Family Members Is Not Required for the Platelet-Derived Growth Factor β Receptor To Initiate Mitogenesis
ABSTRACT The basal activity of Src family kinases is readily detectable throughout the cell cycle and increases by two- to… 
Highly Cited
1996
Highly Cited
1996
Platelet-derived Growth Factor Induces a Long-term Inhibition of N-Methyl-D-aspartate Receptor Function*
Platelet-derived growth factor (PDGF) is a multifunctional protein that plays important roles in many tissues, including the… 
1992
1992
Characterization of platelet-derived growth factor and platelet-derived growth factor receptor expression in asbestos-induced rat mesothelioma.
Although altered expression of platelet-derived growth factor (PDGF) is a hallmark of human mesothelioma, expression of PDGF… 
Highly Cited
1991
Highly Cited
1991
A phosphatidylinositol-3 kinase binds to platelet-derived growth factor receptors through a specific receptor sequence containing phosphotyrosine
Platelet-derived growth factor (PDGF) stimulates autophosphorylation of the PDGF receptor and association of the receptor with… 
Highly Cited
1991
Highly Cited
1991
Epidermal growth factor receptor, platelet-derived growth factor receptor, and c-erbB-2 receptor activation all promote growth but have distinctive effects upon mouse mammary epithelial cell…
Three different receptor tyrosine kinases, epidermal growth factor (EGF), c-erbB-2/neu, and platelet-derived growth factor (PDGF… 
Highly Cited
1990
Highly Cited
1990
Preferential inhibition of the platelet-derived growth factor receptor tyrosine kinase by staurosporine.
Ligand stimulation of the platelet-derived growth factor receptor (PDGF-R) results in rapid activation of the receptor tyrosine… 
Highly Cited
1988
Highly Cited
1988
Role of tyrosine kinase and membrane-spanning domains in signal transduction by the platelet-derived growth factor receptor
Three types of mutations were introduced into the platelet-derived growth factor (PDGF) receptor to cause a loss of PDGF… 
Highly Cited
1988
Highly Cited
1988
Characterization of two monoclonal antibodies reactive with the external domain of the platelet-derived growth factor receptor.
Two monoclonal antibodies against the receptor for platelet-derived growth factor (PDGF) were obtained by immunizing mice with… 
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