Platelet-Derived Growth Factor Receptor

Known as: Platelet Derived Growth Factor Receptors, Receptor, PDGF, Receptors, Platelet-Derived Growth Factor 
Specific receptors on cell membranes that react with PLATELET-DERIVED GROWTH FACTOR, its analogs, or antagonists. The alpha PDGF receptor (RECEPTOR… (More)
National Institutes of Health

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Cell Proliferation Regulatory ProcessCrenolanib BesylateDovitinib LactateImatinib mesylate
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PDGFRL protein, human

Papers overview

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Highly Cited
2008
Highly Cited
2008
Sorafenib in advanced hepatocellular carcinoma.
BACKGROUND No effective systemic therapy exists for patients with advanced hepatocellular carcinoma. A preliminary study… (More)
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Highly Cited
2008
Highly Cited
2008
Combination of vascular endothelial growth factor receptor/platelet-derived growth factor receptor inhibition markedly improves radiation tumor therapy.
PURPOSE Investigations on the combination of radiotherapy with vascular endothelial growth factor (VEGF) and platelet-derived… (More)
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Highly Cited
2006
Highly Cited
2006
AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces…
The growth of solid tumors is dependent on the continued stimulation of endothelial cell proliferation and migration resulting in… (More)
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Highly Cited
2005
Highly Cited
2005
Overexpression of platelet-derived growth factor receptor α in breast cancer is associated with tumour progression
Receptor tyrosine kinases have been extensively studied owing to their frequently abnormal activation in the development and… (More)
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Highly Cited
2004
Highly Cited
2004
Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination
To design therapies for demyelinating diseases such as multiple sclerosis, it will be important to understand the mechanisms that… (More)
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Highly Cited
2003
Highly Cited
2003
SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer.
The purpose of this study was to evaluate the activity of the indolinone kinase inhibitor SU11248 against the receptor tyrosine… (More)
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Highly Cited
2000
Highly Cited
2000
Analysis of receptor signaling pathways by mass spectrometry: identification of vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors.
Oligomerization of receptor protein tyrosine kinases such as the epidermal growth factor receptor (EGFR) by their cognate ligands… (More)
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Highly Cited
1999
Highly Cited
1999
Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact.
Embryological data suggest that endothelial cells (ECs) direct the recruitment and differentiation of mural cell precursors. We… (More)
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Review
1998
Review
1998
Signal transduction via platelet-derived growth factor receptors.
Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility by binding to two related… (More)
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Highly Cited
1992
Highly Cited
1992
Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors.
Analysis of genomic organization and expression of platelet-derived growth factor receptors (PDGFR) and epidermal growth factor… (More)
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