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Dovitinib Lactate

Known as: 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one mono 2-hydroxypropanoate Hydrate, RTK Inhibitor TKI258 
The orally bioavailable lactate salt of a benzimidazole-quinolinone compound with potential antineoplastic activity. Dovitinib strongly binds to… Expand
National Institutes of Health

Papers overview

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2017
2017
Background: Human neuroendocrine tumors (NETs) are highly vascular in nature and reliant on multiple receptor tyrosine kinases… Expand
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Highly Cited
2012
Highly Cited
2012
IntroductionTargeting receptor tyrosine kinases (RTKs) with kinase inhibitors is a clinically validated anti-cancer approach… Expand
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2010
2010
(-)-Epigallocatechin gallate, Abafungin, ACE-031, Adapalene/benzoyl peroxide, AE-37, Aflibercept, AGS-003, Albiglutide… Expand
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2009
2009
3563 Background: TKI258 is a potent receptor tyrosine kinase inhibitor (TKI) that selectively targets VEGFR, PDGFR, FGFR, CSF1R… Expand
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2009
2009
9020 Background: TKI258 (dovitinib lactate), is a multi-tyrosine kinase inhibitor of VEGF receptors-1,2,3, FGF receptors-1, 2, 3… Expand
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2009
2009
e14625 TKI258 (4-amino-5-fluor-3-[5-(4-metylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one, formerly known as CHIR258… Expand
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2008
2008
9026 Background: TKI258 is an inhibitor of type III to V RTKs including VEGF-Rs, FGF-Rs (FGF-R1, 2 and 3), PDGFR-β, c- KIT and… Expand
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2008
2008
14680 Background: TKI258 (dovitinib lactate), is a multi-tyrosine kinase inhibitor of VEGF receptors-1,2,3, FGF receptors-1, 2, 3… Expand
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2008
2008
14691 Background: TKI258 (dovitinib lactate), an inhibitor of type III-V receptor tyrosine kinases (RTK), is being evaluated in… Expand
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