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Crenolanib Besylate

Known as: CP-868,596-26, [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine Monobenzenesulfonate, ARO-002-26 
The besylate salt form of crenolanib, an orally bioavailable benzimidazole targeting the platelet-derived growth factor receptor (PDGFR) subtypes… 
National Institutes of Health

Related topics

Related topics

5 relations
Inhibition of Cell ProliferationPlatelet-Derived Growth Factor ReceptorPositive Regulation of ApoptosisReceptor Tyrosine Kinase Inhibition

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Inhibition of the platelet-derived growth factor receptor beta (PDGFRB) using gene silencing, crenolanib besylate, or imatinib mesylate hampers the malignant phenotype of mesothelioma cell lines
Malignant pleural mesothelioma (MPM) is a cancer of the pleural cavity resistant to chemotherapy. The identification of novel… 
Highly Cited
2016
Highly Cited
2016
Crenolanib besylate, a type I pan-FLT3 inhibitor, to demonstrate clinical activity in multiply relapsed FLT3-ITD and D835 AML.
7008Background: We investigated the clinical activity, PK, safety and resistance mechanisms to single-agent crenolanib patients… 
2016
2016
Dose escalating study of crenolanib besylate in advanced GIST patients with PDGFRA D842V activating mutations.
11010Background: PDGFRA D842V mutated GIST is resistant to all available TKIs with a median PFS of ≤ 2.8m and a median OS 14.7m… 
2016
2016
Préparation solide contenant un agent antioxydant
Le probleme aborde par la presente invention consiste a proposer une preparation pharmaceutique solide qui comprend du… 
2016
2016
PDCT-10. FIRST IN PEDIATRICS PHASE I STUDY OF CRENOLANIB BESYLATE (CP-868,596-26) ADMINISTERED DURING AND AFTER RADIATION THERAPY (RT) IN NEWLY-DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) AND…
Highly Cited
2015
Highly Cited
2015
Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1.
BACKGROUND & AIMS In gastrointestinal muscles, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT) is… 
2015
2015
The FLT3 and PDGFR inhibitor crenolanib is a substrate of the multidrug resistance protein ABCB1 but does not inhibit transport function at pharmacologically relevant concentrations
SummaryBackground Crenolanib (crenolanib besylate, 4-piperidinamine, 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl… 
2014
2014
First-in-pediatrics phase I study of crenolanib besylate (CP-868,596-26) administered during and after radiation therapy (RT) in newly diagnosed diffuse intrinsic pontine glioma (DIPG) and recurrent…
10064 Background: Children diagnosed with DIPG have a median survival of less than one year despite RT, the primary modality of… 
2012
2012
Abstract 2742: Cerebral microdialysis for simultaneous sampling of crenolanib (PDGFR inhibitor) and erlotinib (EGFR inhibitor) in mouse models of glioma
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Cerebral microdialysis, a technique used to… 
2012
2012
346 First in Pediatrics Phase I Study of Crenolanib Besylate (CP-868, 596–26) Administered During and After Radiation Therapy (RT) in Newly-diagnosed Diffuse Intrinsic Pontine Glioma (DIPG) and…
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