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Mechanism of action and in vivo role of platelet-derived growth factor.
Platelet-derived growth factor (PDGF) is a major mitogen for connective tissue cells and certain other cell types. It is a dimeric molecule consisting of disulfide-bonded, structurally similar A- and… Expand
Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.
- J. Waltenberger, L. Claesson-Welsh, A. Siegbahn, M. Shibuya, C. Heldin
- Biology, Medicine
- The Journal of biological chemistry
- 28 October 1994
Vascular endothelial growth factor (VEGF) is a homodimeric peptide growth factor which binds to two structurally related tyrosine kinase receptors denoted Flt1 and KDR. In order to compare the signal… Expand
TGF-β signalling from cell membrane to nucleus through SMAD proteins
The recent identification of the SMAD family of signal transducer proteins has unravelled the mechanisms by which transforming growth factor-β (TGF-β) signals from the cell membrane to the nucleus.… Expand
High interstitial fluid pressure — an obstacle in cancer therapy
Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in tumour treatment, as it results in… Expand
TGF-beta signalling from cell membrane to nucleus through SMAD proteins.
The recent identification of the SMAD family of signal transducer proteins has unravelled the mechanisms by which transforming growth factor-beta (TGF-beta) signals from the cell membrane to the… Expand
Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.
TGF-beta signals from the membrane to the nucleus through serine/threonine kinase receptors and their downstream effectors, termed SMAD proteins. The activated TGF-beta receptor induces… Expand
Co‐localization of NG2 proteoglycan and PDGF α‐receptor on O2A progenitor cells in the developing rat brain
- A. Nishiyama, X. Lin, N. Giese, C. Heldin, W. Stallcup
- Biology, Medicine
- Journal of neuroscience research
- 1 February 1996
A detailed comparison in the developing rat central nervous system between the distribution of the NG2 proteoglycan and the α‐receptor for platelet‐derived growth factor (PDGF) shows that these two… Expand
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling
TGF-β signals from the membrane to the nucleus through serine/threonine kinase receptors and their downstream effectors, termed SMAD proteins. The activated TGF-β receptor induces phosphorylation of… Expand
Signal transduction via platelet-derived growth factor receptors.
Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility by binding to two related protein tyrosine kinase receptors. Ligand binding induces receptor… Expand
TGF‐β receptor‐mediated signalling through Smad2, Smad3 and Smad4
Smad family members are newly identified essential intracellular signalling components of the transforming growth factor‐β (TGF‐β) superfamily. Smad2 and Smad3 are structurally highly similar and… Expand