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PKC412

Known as: PKC 412, PKC-412 
A synthetic indolocarbazole protein kinase C (PKC) inhibitor. As a nonspecific inhibitor of protein kinase C enzymes, midostaurin inhibits oncogenic… 
National Institutes of Health

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CGP41251

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midostaurin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
FLT 3 Inhibitors for the Treatment of Acute Myeloid Leukemia
634. 42. Hexner EO, Serdikoff C, Jan M, et al. Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and… 
Review
2010
Review
2010
FLT3 inhibitors for the treatment of acute myeloid leukemia.
The fms-like receptor tyrosine kinase-3 (FLT3), which is important for the normal development of hematopoietic stem cells and… 
2007
2007
D-HPLC analysis of the entire FLT3 gene in MLL rearranged and hyperdiploid acute lymphoblastic leukemia
MLL rearranged and hyperdiploid acute lymphoblastic leukemia (ALL) are characterized by high-level FLT3 expression and… 
Review
2006
Review
2006
KIT mutations in mastocytosis and their potential as therapeutic targets.
2006
2006
Synergistic Growth-Inhibitory Effects of Two Tyrosine Kinase Inhibitors, Dasatinib and PKC412, on Neoplastic Mast Cells Expressing the D816V-Mutated Oncogenic Variant of KIT.
In a majority of all patients with systemic mastocytosis (SM) including aggressive SM and mast cell leukemia (MCL), neoplastic… 
2005
2005
PKC 412 sensitizes U1810 non-small cell lung cancer cells to DNA damage.
2005
2005
N-benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells.
Multiple myeloma is a clonal malignancy of plasma cells that invariably progresses to a chemoresistant state. The PI3K/Akt… 
2003
2003
Effect of PKC412, an inhibitor of protein kinase C, on spontaneous metastatic model mice.
We investigated the anti-metastatic effect of PKC412, a selective inhibitor of protein kinase C (PKC), on a spontaneous… 
Highly Cited
2001
Highly Cited
2001
Differential p53-dependent mechanism of radiosensitization in vitro and in vivo by the protein kinase C-specific inhibitor PKC412.
The cellular response to ionizing radiation is governed by the DNA-damage recognition process but is also modulated by… 
2000
2000
Protein kinase C inhibitor and irradiation-induced apoptosis: relevance of the cytochrome c-mediated caspase-9 death pathway.
Caspases are a family of cysteine proteases that constitute the apoptotic cell death machinery. We report the importance of the… 
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