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PKC412

Known as: PKC 412, PKC-412 
A synthetic indolocarbazole protein kinase C (PKC) inhibitor. As a nonspecific inhibitor of protein kinase C enzymes, midostaurin inhibits oncogenic… Expand
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
Activating mutations in the receptor tyrosine kinase FLT3 are present in up to approximately 30% of acute myeloid leukemia (AML… Expand
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Highly Cited
2006
Highly Cited
2006
Activating mutations in the FLT3 tyrosine kinase (TK) occur in approximately 35% of patients with acute myeloid leukemia (AML… Expand
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Review
2006
Review
2006
Blood eosinophilia signifies either a cytokine‐mediated reactive phenomenon (secondary) or an integral phenotype of an underlying… Expand
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Highly Cited
2005
Highly Cited
2005
BACKGROUND AND AIMS Resistance is a major challenge in the treatment of patients with gastrointestinal stromal tumors (GISTs). We… Expand
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Highly Cited
2005
Highly Cited
2005
Leukemic cells from 30% of patients with acute myeloid leukemia (AML) have an activating mutation in the FLT3 (fms-like tyrosine… Expand
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Highly Cited
2005
Highly Cited
2005
Constitutively activated forms of the transmembrane receptor tyrosine kinase c-KIT have been associated with systemic mast cell… Expand
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Highly Cited
2005
Highly Cited
2005
The majority of patients with systemic mast cell disease express the imatinib-resistant Asp816Val (D816V) mutation in the KIT… Expand
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Highly Cited
2002
Highly Cited
2002
Constitutively activating FLT3 receptor mutations have been found in 35% of patients with acute myeloblastic leukemia (AML). Here… Expand
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Highly Cited
2001
Highly Cited
2001
PURPOSE N-Benzoyl staurosporine (PKC412) is a protein kinase C inhibitor with antitumor activity in laboratory models. We… Expand
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Highly Cited
2000
Highly Cited
2000
The staurosporine derivative PKC412 was originally identified as an inhibitor of protein kinase C (PKC) and subsequently shown to… Expand
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