PKC412

Known as: PKC 412, PKC-412 
A synthetic indolocarbazole protein kinase C (PKC) inhibitor. As a nonspecific inhibitor of protein kinase C enzymes, midostaurin inhibits oncogenic… (More)
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
PURPOSE Mutations leading to constitutive activation of the FMS-like tyrosine kinase 3 receptor (FLT3) occur in blasts of 30% of… (More)
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Highly Cited
2006
Highly Cited
2006
Activating mutations in the FLT3 tyrosine kinase (TK) occur in approximately 35% of patients with acute myeloid leukemia (AML… (More)
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Highly Cited
2006
Highly Cited
2006
In most patients with systemic mastocytosis (SM), including aggressive SM and mast cell leukemia (MCL), neoplastic cells express… (More)
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Highly Cited
2005
Highly Cited
2005
Leukemic cells from 30% of patients with acute myeloid leukemia (AML) have an activating mutation in the FLT3 (fms-like tyrosine… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND AND AIMS Resistance is a major challenge in the treatment of patients with gastrointestinal stromal tumors (GISTs). We… (More)
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Highly Cited
2005
Highly Cited
2005
Constitutively activated forms of the transmembrane receptor tyrosine kinase c-KIT have been associated with systemic mast cell… (More)
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Highly Cited
2005
Highly Cited
2005
The majority of patients with systemic mast cell disease express the imatinib-resistant Asp816Val (D816V) mutation in the KIT… (More)
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Highly Cited
2004
Highly Cited
2004
Human stem cell leukemia-lymphoma syndrome usually presents itself as a myeloproliferative disorder (MPD) that evolves to acute… (More)
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Highly Cited
2004
Highly Cited
2004
Presence of the activating length mutation (LM) in the juxtamembrane domain or point mutation in the kinase domain of FMS-like… (More)
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Highly Cited
2001
Highly Cited
2001
PURPOSE N-Benzoyl staurosporine (PKC412) is a protein kinase C inhibitor with antitumor activity in laboratory models. We… (More)
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