CGP41251
National Institutes of Health
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Protein kinase C (PKC) represents a family of phospholipid-dependent serine/threonine kinase. PKC was detected in almost all…
INTRODUCTION
PKC412 (formally CGP41251) selectively inhibits protein kinase C (PKC) isoforms and has been shown to be cytotoxic…
PKC isoenzymes were found to be involved in proliferation, antitumor drug resistance and apoptosis. Therefore, it has been tried…
Components of cell signaling pathways provide important targets for anticancer drugs. Protein kinase C (PKC) is a serine…
The antitumor effect of CGP41251 (4'-N-benzoyl staurosporine), a selective protein kinase C (PKC) inhibitor, was examined on two…
The intracellular signaling involved in the mechanism of action of zonula occludens toxin (ZOT) was studied using several in…
Stimulation of human neutrophils by the receptor agonist N-formylmethionyl-leucyl-phenylalanine (fMLP) results in a respiratory…