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CGP41251

 

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Topic mentions per year

1993-2018
01219932018

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2 relations

Broader (2)

PKC412midostaurin

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Related mentions per year

1993-2018
1990200020102020
CGP41251
PKC412
midostaurin

Papers overview

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2007
2007
PKC412 (CGP41251) modulates the proliferation and lipopolysaccharide-induced inflammatory responses of RAW 264.7 macrophages.
PKC412 (CGP41251) is a multitarget protein kinase inhibitor with anti-tumor activities. Here, we investigated the effects of… (More)
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2005
2005
Effects of the kinase inhibitor CGP41251 (PKC 412) on lymphocyte activation and TNF-alpha production.
CGP41251 is a serine/threonine and tyrosine kinase inhibitor that is a novel anticancer agent. Because the kinases that CGP41251… (More)
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Highly Cited
2004
Highly Cited
2004
Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity.
It is well established that oxidative stress is enhanced in diabetes. However, the major in vivo source of oxidative stress is… (More)
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Highly Cited
2004
Highly Cited
2004
Proangiogenic action of thyroid hormone is fibroblast growth factor-dependent and is initiated at the cell surface.
The effects of thyroid hormone analogues on modulation of angiogenesis have been studied in the chick chorioallantoic membrane… (More)
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2004
2004
Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-A
Resveratrol, a naturally occurring stilbene with antitumor properties, caused mitogen-activated protein kinase [MAPK… (More)
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2002
2002
A novel treatment approach for low grade lymphoproliferative disorders using PKC412 (CGP41251), an inhibitor of protein kinase C.
INTRODUCTION PKC412 (formally CGP41251) selectively inhibits protein kinase C (PKC) isoforms and has been shown to be cytotoxic… (More)
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2002
2002
Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro.
BACKGROUND AND OBJECTIVES The staurosporine derivative PKC412 (CGP41251) is a more selective inhibitor of the conventional… (More)
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1999
1999
The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients.
Components of cell signaling pathways provide important targets for anticancer drugs. Protein kinase C (PKC) is a serine… (More)
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1996
1996
Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells.
The antitumor effect of CGP41251 (4'-N-benzoyl staurosporine), a selective protein kinase C (PKC) inhibitor, was examined on two… (More)
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Highly Cited
1995
Highly Cited
1995
Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.
The intracellular signaling involved in the mechanism of action of zonula occludens toxin (ZOT) was studied using several in… (More)
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