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CGP41251

National Institutes of Health

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2 relations

Broader (2)

PKC412midostaurin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders.
Highly Cited
2004
Highly Cited
2004
Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity.
Review
2003
Review
2003
Selective protein kinase C inhibitors and their applications.
  • G. Shen
  • Current drug targets. Cardiovascular…
  • 2003
  • Corpus ID: 3162668
Protein kinase C (PKC) represents a family of phospholipid-dependent serine/threonine kinase. PKC was detected in almost all… 
2002
2002
A novel treatment approach for low grade lymphoproliferative disorders using PKC412 (CGP41251), an inhibitor of protein kinase C.
INTRODUCTION PKC412 (formally CGP41251) selectively inhibits protein kinase C (PKC) isoforms and has been shown to be cytotoxic… 
Review
2001
Review
2001
Modulation of protein kinase C in antitumor treatment.
  • J. Hofmann
  • Reviews of physiology, biochemistry and…
  • 2001
  • Corpus ID: 25362603
PKC isoenzymes were found to be involved in proliferation, antitumor drug resistance and apoptosis. Therefore, it has been tried… 
Highly Cited
1999
Highly Cited
1999
The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients.
Components of cell signaling pathways provide important targets for anticancer drugs. Protein kinase C (PKC) is a serine… 
Review
1998
Review
1998
Analogs of staurosporine: potential anticancer drugs?
  • A. Gescher
  • General pharmacology
  • 1998
  • Corpus ID: 20715983
1996
1996
Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells.
The antitumor effect of CGP41251 (4'-N-benzoyl staurosporine), a selective protein kinase C (PKC) inhibitor, was examined on two… 
Highly Cited
1995
Highly Cited
1995
Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.
The intracellular signaling involved in the mechanism of action of zonula occludens toxin (ZOT) was studied using several in… 
Highly Cited
1993
Highly Cited
1993
Protein kinase C activity is not involved in N-formylmethionyl-leucyl-phenylalanine-induced phospholipase D activation in human neutrophils, but is essential for concomitant NADPH oxidase activation…
Stimulation of human neutrophils by the receptor agonist N-formylmethionyl-leucyl-phenylalanine (fMLP) results in a respiratory… 
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