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CGP41251

 
National Institutes of Health

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2 relations

Broader (2)

PKC412midostaurin

Papers overview

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Highly Cited
2004
Highly Cited
2004
Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity.
It is well established that oxidative stress is enhanced in diabetes. However, the major in vivo source of oxidative stress is… Expand
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2004
2004
Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha.
Resveratrol, a naturally occurring stilbene with antitumor properties, caused mitogen-activated protein kinase [MAPK… Expand
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Review
2003
Review
2003
Selective protein kinase C inhibitors and their applications.
  • Garry X Shen
  • Current drug targets. Cardiovascular…
  • 2003
    • Corpus ID: 3162668
Protein kinase C (PKC) represents a family of phospholipid-dependent serine/threonine kinase. PKC was detected in almost all… Expand
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2002
2002
A novel treatment approach for low grade lymphoproliferative disorders using PKC412 (CGP41251), an inhibitor of protein kinase C.
INTRODUCTION PKC412 (formally CGP41251) selectively inhibits protein kinase C (PKC) isoforms and has been shown to be cytotoxic… Expand
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2002
2002
Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro.
BACKGROUND AND OBJECTIVES The staurosporine derivative PKC412 (CGP41251) is a more selective inhibitor of the conventional… Expand
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Review
2001
Review
2001
Modulation of protein kinase C in antitumor treatment.
  • Johann Hofmann
  • Reviews of physiology, biochemistry and…
  • 2001
    • Corpus ID: 25362603
PKC isoenzymes were found to be involved in proliferation, antitumor drug resistance and apoptosis. Therefore, it has been tried… Expand
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1999
1999
The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients.
Components of cell signaling pathways provide important targets for anticancer drugs. Protein kinase C (PKC) is a serine… Expand
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Review
1998
Review
1998
Analogs of staurosporine: potential anticancer drugs?
1. Protein kinase C (PKC) is a family of serine/threonine-directed protein kinases that are pivotal regulators of cellular growth… Expand
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1996
1996
Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells.
The antitumor effect of CGP41251 (4'-N-benzoyl staurosporine), a selective protein kinase C (PKC) inhibitor, was examined on two… Expand
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Highly Cited
1995
Highly Cited
1995
Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.
The intracellular signaling involved in the mechanism of action of zonula occludens toxin (ZOT) was studied using several in… Expand
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