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CGP41251

 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

PKC412midostaurin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders.
Vascular smooth muscle (VSM) plays an important role in maintaining vascular tone. In addition to Ca2+-dependent myosin light… Expand
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Highly Cited
2004
Highly Cited
2004
Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity.
It is well established that oxidative stress is enhanced in diabetes. However, the major in vivo source of oxidative stress is… Expand
Highly Cited
2004
Highly Cited
2004
Inhibitory effect of epidermal growth factor on resveratrol-induced apoptosis in prostate cancer cells is mediated by protein kinase C-alpha.
Resveratrol, a naturally occurring stilbene with antitumor properties, caused mitogen-activated protein kinase [MAPK… Expand
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2002
2002
A novel treatment approach for low grade lymphoproliferative disorders using PKC412 (CGP41251), an inhibitor of protein kinase C.
INTRODUCTION PKC412 (formally CGP41251) selectively inhibits protein kinase C (PKC) isoforms and has been shown to be cytotoxic… Expand
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Review
2001
Review
2001
Modulation of protein kinase C in antitumor treatment.
  • J. Hofmann
  • Reviews of physiology, biochemistry and…
  • 2001
    • Corpus ID: 25362603
PKC isoenzymes were found to be involved in proliferation, antitumor drug resistance and apoptosis. Therefore, it has been tried… Expand
Highly Cited
1999
Highly Cited
1999
The protein kinase C inhibitor CGP41251 suppresses cytokine release and extracellular signal-regulated kinase 2 expression in cancer patients.
Components of cell signaling pathways provide important targets for anticancer drugs. Protein kinase C (PKC) is a serine… Expand
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Review
1998
Review
1998
Analogs of staurosporine: potential anticancer drugs?
  • A. Gescher
  • General pharmacology
  • 1998
    • Corpus ID: 20715983
1. Protein kinase C (PKC) is a family of serine/threonine-directed protein kinases that are pivotal regulators of cellular growth… Expand
1996
1996
Antitumor effect of CGP41251, a new selective protein kinase C inhibitor, on human non-small cell lung cancer cells.
The antitumor effect of CGP41251 (4'-N-benzoyl staurosporine), a selective protein kinase C (PKC) inhibitor, was examined on two… Expand
Highly Cited
1995
Highly Cited
1995
Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.
The intracellular signaling involved in the mechanism of action of zonula occludens toxin (ZOT) was studied using several in… Expand
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Highly Cited
1993
Highly Cited
1993
Protein kinase C activity is not involved in N-formylmethionyl-leucyl-phenylalanine-induced phospholipase D activation in human neutrophils, but is essential for concomitant NADPH oxidase activation…
Stimulation of human neutrophils by the receptor agonist N-formylmethionyl-leucyl-phenylalanine (fMLP) results in a respiratory… Expand
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