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CGP 41251

Known as: CGP 41 251, CGP-41251 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Alkaloidsmidostaurin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2000
Review
2000
Staurosporine analogues - pharmacological toys or useful antitumour agents?
Highly Cited
2000
Highly Cited
2000
Differential Requirement for Classic and Novel PKC Isoforms in Respiratory Burst and Phagocytosis in RAW 264.7 Cells1
The binding of Ab (IgG)-opsonized particles by FcγRs on macrophages results in phagocytosis of the particles and generation of a… 
Review
1999
Review
1999
Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent.
1998
1998
Reversal of multidrug resistance by the staurosporine derivatives CGP 41251 and CGP 42700
It has been shown previously that the staurosporine derivative CGP 41251, a specific inhibitor of protein kinase C (IC50 = 50 nM… 
Highly Cited
1997
Highly Cited
1997
Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents.
1997
1997
CGP 41251 and tamoxifen selectively inhibit mitogen-activated protein kinase activation and c-Fos phosphoprotein induction by substance P in human astrocytoma cells.
The substance P (SP) receptor (NK-1 subtype) is widely expressed in primary human astrocytomas and glioblastomas and many brain… 
Highly Cited
1997
Highly Cited
1997
Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy.
The development of a malignant tumor involves the progressive acquisition of mutations and epigenetic abnormalities in multiple… 
1995
1995
Differential inhibition of cytosolic and membrane‐derived protein kinase C activity by staurosporine and other kinase inhibitors
Highly Cited
1994
Highly Cited
1994
The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor activity, reverses multidrug resistance
Multidrug resistance (MDR) is frequently associated with overexpression of a 170‐kDa P‐glycoprotein (Pgp). Data suggest altered… 
Highly Cited
1992
Highly Cited
1992
Differential inhibition of the epidermal growth factor-, platelet-derived growth factor-, and protein kinase C-mediated signal transduction pathways by the staurosporine derivative CGP 41251.
The microbial alkaloid staurosporine is a potent but nonselective inhibitor of protein kinases. The derivative CGP 41251 has been… 
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