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CGP 41251

Known as: CGP 41 251, CGP-41251 
National Institutes of Health

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2 relations

Broader (2)

Alkaloidsmidostaurin

Papers overview

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Highly Cited
2001
Highly Cited
2001
Protein kinase C effectors bind to multidrug ABC transporters and inhibit their activity.
P-Glycoprotein and homologous multidrug transporters contain a phosphorylatable linker sequence that was proposed to control drug… 
1998
1998
Reversal of multidrug resistance by the staurosporine derivatives CGP 41251 and CGP 42700
It has been shown previously that the staurosporine derivative CGP 41251, a specific inhibitor of protein kinase C (IC50 = 50 nM… 
1998
1998
Treatment of human glioblastoma cells with the staurosporine derivative CGP 41251 inhibits CDC2 and CDK2 kinase activity and increases radiation sensitivity.
CGP, 41251, a staurosporine derivative, is a potent inhibitor of protein kinase C (PKC). In recent studies we found that this… 
Highly Cited
1997
Highly Cited
1997
Activation of protein kinase C subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents.
1997
1997
CGP 41251 and tamoxifen selectively inhibit mitogen-activated protein kinase activation and c-Fos phosphoprotein induction by substance P in human astrocytoma cells.
The substance P (SP) receptor (NK-1 subtype) is widely expressed in primary human astrocytomas and glioblastomas and many brain… 
1997
1997
The promoting effects of bFGF and astrocyte extracellular matrix on process outgrowth by adult human oligodendrocytes are mediated by protein kinase C
1995
1995
Differential inhibition of cytosolic and membrane‐derived protein kinase C activity by staurosporine and other kinase inhibitors
1995
1995
The antitumor activity of doxorubicin against drug-resistant murine carcinoma is enhanced by oral administration of a synthetic staurosporine analogue, CGP 41251.
We evaluated the therapeutic efficacy against murine drug-sensitive and drug-resistant tumor of a combination chemotherapy… 
Highly Cited
1994
Highly Cited
1994
The protein kinase C inhibitor CGP 41251, a staurosporine derivative with antitumor activity, reverses multidrug resistance
Multidrug resistance (MDR) is frequently associated with overexpression of a 170‐kDa P‐glycoprotein (Pgp). Data suggest altered… 
1993
1993
Effects of a new protein kinase C inhibitor CGP 41251 on T cell functions: inhibition of activation, growth, and target cell killing.
The effects of CGP 41251, a specific inhibitor of protein kinase C (PKC), its inactive derivative CGP 42700, and of staurosporine… 
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