• Publications
  • Influence
Metalloproteinases in biology and pathology of the nervous system
Some of the beneficial functions of MMPs during neural development are considered and their roles in repair after brain injury are speculated, as well as a family of proteins known as ADAMs, as some of the properties previously ascribed to M MPs are possibly the result of ADAM activity. Expand
Matrix metalloproteinases and diseases of the CNS
Both the identity of the MMP and its cellular origin could determine whether disease pathogenesis or regeneration occurs, and thus synthetic MMP inhibitors might be valuable for treating some CNS diseases. Expand
Metalloproteinases: Mediators of Pathology and Regeneration in the CNS
  • V. Yong
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • 1 December 2005
General principles that govern the expression of metalloproteinases in the nervous system are discussed and their mechanisms in regulating neurogenesis, myelin formation and axonal growth are focused on. Expand
Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosis.
Results indicate that minocycline may constitute a safe and inexpensive therapy for multiple sclerosis and inhibit MMP activity, reduced production of MMP-9 and decreased the transmigration of T lymphocytes across a fibronectin matrix barrier. Expand
Pro‐regenerative properties of cytokine‐activated astrocytes
Here, a re‐assessment of cytokine‐activated astrocytes is necessary to promote the thesis that cytokines elicit potent neuroprotective and regenerative responses from astroCytes. Expand
The promise of minocycline in neurology
The evidence for the efficacy of minocyCline in several animal models of neurological disease is described, the mechanisms by which minocycline affects a range of neurological diseases with diverse causes are discussed, and the emerging investigation of minocrycline in clinical neurology is introduced. Expand
Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases
Select MMPs exhibit increased expression after ICH, whereas minocycline is neuroprotective after I CH by suppressing monocytoid cell activation and downregulating MMP‐12 expression. Expand
Human endogenous retrovirus glycoprotein–mediated induction of redox reactants causes oligodendrocyte death and demyelination
It is reported that the HERV-W encoded glycoprotein syncytin is upregulated in glial cells within acute demyelinating lesions of multiple sclerosis patients. Expand
P2X7-Like Receptor Activation in Astrocytes Increases Chemokine Monocyte Chemoattractant Protein-1 Expression via Mitogen-Activated Protein Kinase
The roles for ATP P2X7 receptor activation in inducing MCP-1 upregulation in corticectomy, an in vivo model of trauma, andPurinergic transmitter receptors in astrocytes are important in regulating chemokine synthesis are tested, indicating that purinergic transmitters in astROcytes may be important in mediating communication with hematopoietic inflammatory cells. Expand
Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice.
Functional assessments demonstrated that minocycline administration significantly improved both hindlimb function and strength from 3 to 28 days after injury compared with vehicle controls, and there was evidence of axonal sparing as determined using fluorogold labelling of the rubrospinal tract and by Bielchowsky silver stain. Expand