The tor pathway: a target for cancer therapy
- M. Bjornsti, P. Houghton
- BiologyNature Reviews. Cancer
- 1 May 2004
In addition to the role of rapamycin as an immune suppressant, emerging data indicate that genetic and metabolic changes accompanying malignant transformation might cause hypersensitivity to TOR inhibition.
Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation.
- P. Houghton, R. Zarka, B. de Las Heras, J. Hoult
- Biology, ChemistryPlanta Medica
- 1 February 1995
The pharmacological properties of the oil support the traditional use of N. sativa and its derived products as a treatment for rheumatism and related inflammatory diseases and is greater than is expected from its content of thymoquinone.
Laboratory Handbook for the Fractionation of Natural Extracts
- P. Houghton, A. Raman
- MedicineSpringer US
- 31 March 1998
You can easily find and get this laboratory handbook for fractionation of natural extracts by reading this site and the soft file concept is offered right here.
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin.
- G. Brunn, C. Hudson, R. Abraham
- Biology, ChemistryScience
- 4 July 1997
A role for mTOR in translational control is defined and further insights into the mechanism whereby rapamycin inhibits G1-phase progression in mammalian cells are offered.
alpha-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus.
- Hannatu K. Ali, P. Houghton, A. Soumyanath
- Biology, MedicineJournal of Ethnopharmacology
- 11 October 2006
Acetylcholinesterase inhibitors from plants.
- P. Mukherjee, Venkatesan Kumar, Mainak Mal, P. Houghton
- BiologyPhytomedicine
- 10 April 2007
Targeting mTOR signaling for cancer therapy.
- Shile Huang, P. Houghton
- BiologyCurrent opinion in pharmacology (Print)
- 1 August 2003
Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations.
- W. T. Beck, T. Grogan, R. Weinstein
- Medicine, BiologyCancer Research
- 1 July 1996
Although detection of Pgp and MDR1 is at present likely to be more reliable in leukemias and lymphomas than in solid tumors, accurate measurement of low levels of P gp expression under most conditions remains an elusive goal.
Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro
- P. Houghton, G. Germain, P. Traxler
- Biology, ChemistryCancer Research
- 1 April 2004
It is shown that imatinib mesylate potently reverses ABCG2-mediated resistance to topotecan and SN-38 and significantly increases accumulation of topotECan only in cells expressing functional ABCG 2.
Acetylcholinesterase inhibitors from plants and fungi.
- P. Houghton, Yuhao Ren, M. Howes
- Biology, ChemistryNatural product reports (Print)
- 29 March 2006
183 compounds obtained from plants and fungi which have been shown to inhibit acetylcholinesterase are described, mainly alkaloids although some meroterpenoids from fungi have also been found to be active and display better selectivity.
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