P. Houghton

Publications1,005
h-index108
Citations44,284
Highly Influential Citations1,355
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The tor pathway: a target for cancer therapy
TLDR
In addition to the role of rapamycin as an immune suppressant, emerging data indicate that genetic and metabolic changes accompanying malignant transformation might cause hypersensitivity to TOR inhibition. Expand
Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation.
TLDR
The pharmacological properties of the oil support the traditional use of N. sativa and its derived products as a treatment for rheumatism and related inflammatory diseases and is greater than is expected from its content of thymoquinone. Expand
Laboratory Handbook for the Fractionation of Natural Extracts
If you get the printed book in on-line book store, you may also find the same problem. So, you must move store to store and search for the available there. But, it will not happen here. The book that… Expand
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin.
TLDR
A role for mTOR in translational control is defined and further insights into the mechanism whereby rapamycin inhibits G1-phase progression in mammalian cells are offered. Expand
alpha-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus.
TLDR
Results revealed that the oleanolic acid and ursolic acid (2:1) mixture was a potent alpha-amylase inhibitor with IC(50)=2.01 microg/ml (4.41 microM) and that it contributes significantly to the alpha-AMylase inhibition activity of the extract. Expand
The Scientific Basis for the Reputed Activity of Valerian
  • P. Houghton
  • Biology, Medicine
  • The Journal of pharmacy and pharmacology
  • 1 September 1998
The underground organs of members of the genus Valeriana (Valerianaceae), as well as related genera such as Nardostachys, are used in the traditional medicine of many cultures as mild sedatives and… Expand
Acetylcholinesterase inhibitors from plants.
TLDR
This article aims to provide a comprehensive literature survey of plants that have been tested for AChE inhibitory activity and reports numerous phytoconstituents and promising plant species as A ChE inhibitors. Expand
Targeting mTOR signaling for cancer therapy.
TLDR
Emerging results suggest that inhibition of mTOR signaling can be exploited as a potential tumour-selective therapeutic strategy. Expand
Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations.
TLDR
Although detection of Pgp and MDR1 is at present likely to be more reliable in leukemias and lymphomas than in solid tumors, accurate measurement of low levels of P gp expression under most conditions remains an elusive goal. Expand
In‐vitro Inhibition of Human Erythrocyte Acetylcholinesterase by Salvia lavandulaefolia Essential Oil and Constituent Terpenes
TLDR
Sage (Salvia spp) essential oil and some of its constituent terpenes on human erythrocyte acetylcholinesterase were examined in‐vitro to study the effects of Salvia lavandulaefolia Vahl on memory. Expand
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