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Addiction to Oncogenes--the Achilles Heal of Cancer
TLDR
New work demonstrating that even brief inactivation of an oncogene can permanently reverse the malignant phenotype of some types of tumor is discussed. Expand
Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines.
TLDR
These studies provide support for the use of resveratrol in chemoprevention and cancer therapy trials and suggest Cyclin D1, cyclin B1, beta-catenin, and apoptotic index could be useful biomarkers to evaluate treatment efficacy. Expand
Effects of epigallocatechin-3-gallate on growth, epidermal growth factor receptor signaling pathways, gene expression, and chemosensitivity in human head and neck squamous cell carcinoma cell lines.
TLDR
These findings provide insights into molecular mechanisms of growth inhibition by EGCG and suggest that this naturally occurring compound may be useful, when used alone or in combination with other agents, in the chemoprevention and/or treatment of HNSCC. Expand
Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction.
TLDR
The results suggest that EGCG inhibits VEGF production by inhibiting both the constitutive activation of Stat3 and NF-kappa B, but not extracellular-signal-regulated kinase (ERK) or Akt, in these cells. Expand
Novel Roles of Specific Isoforms of Protein Kinase C in Activation of the c-fos Serum Response Element
TLDR
Findings indicate that specific isoforms of PKC can enhance the activities of at least three signaling pathways that converge on the SRE: c-Raf–MEK1–ERK–TCF, MEKK1-SEK1-JNK- TCF, and rhoA-SRF. Expand
Constitutive activation of signal transducers and activators of transcription 3 correlates with cyclin D1 overexpression and may provide a novel prognostic marker in head and neck squamous cell
TLDR
This study provides the first evidence that in HNSCC, constitutive activation of Stat3 plays a causative role in overexpression of cyclin D1, and in clinical studies, Stat3 activation may provide a novel prognostic factor. Expand
Inhibition of protein kinase C by tamoxifen.
TLDR
These findings suggest that the growth-inhibitory and cytotoxic effects of tamoxifen, which have been observed at microM concentrations of the drug, may be in part due to its effects on protein kinase C. Expand
Multiple functions of p27Kip1 and its alterations in tumor cells: a review
TLDR
Current information on the functions of p27Kip1, its abnormalities found in human tumors, and the possible clinical implications of these findings with respect to the management of cancer patients are reviewed. Expand
(−)-Epigallocatechin Gallate and Polyphenon E Inhibit Growth and Activation of the Epidermal Growth Factor Receptor and Human Epidermal Growth Factor Receptor-2 Signaling Pathways in Human Colon
TLDR
EGCG or Poly E may be useful in the chemoprevention and/or treatment of colon cancer and this mixture of catechins may exert synergistic effects. Expand
Mechanisms of Disease: oncogene addiction—a rationale for molecular targeting in cancer therapy
TLDR
How high-throughput screening methods, including gene-expression profiling and proteomics, and emerging methods for analyzing complex cellular networks can be used to identify the state of oncogene addiction, i.e. the 'Achilles' heel,' in specific cancers are discussed. Expand
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