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lofexidine

Known as: 1H-imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-, 2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline, lofexidine [Chemical/Ingredient] 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (4)

Adrenergic alpha-2 Receptor AgonistsAntihypertensive AgentsClonidineNarcotic Antagonists

Narrower (1)

Britlofex
Lofexidine hydrochlorideanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
QT interval increased after single dose of lofexidine
Lofexidine (BritLofex, Britannia) is an α 2 agonist used for opioid detoxification.1 We report one case of an increased QT… 
2003
2003
The effectiveness of combined naloxone/lofexidine in opiate detoxification: results from a double-blind randomized and placebo-controlled trial.
The efficacy of lofexidine/naloxone was compared with lofexidine/placebo in a double-blind, randomized, placebo-controlled trial… 
Review
2002
Review
2002
α2‐Adrenergic agonists in opioid withdrawal
Objectives This paper presents the main findings of a systematic (Cochrane) review of the effectiveness of α2-adrenergic agonists… 
1999
1999
The Use of Lofexidine by Drug Dependency Units in the United Kingdom
Data were collected on 1,074 opiate detoxifications conducted with lofexidine, from 40 drug dependency units in the United… 
Highly Cited
1998
Highly Cited
1998
Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification.
1986
1986
Lofexidine in alcohol withdrawal states.
Twenty-eight patients admitted to hospital for alcohol withdrawal were treated with lofexidine, an alpha adrenergic agonist of… 
1983
1983
Opiate withdrawal using lofexidine, a clonidine analogue with fewer side effects.
In an open clinical trial, lofexidine, an alpha-noradrenergic agonist similar to clonidine, was administered to 30 opiate… 
Highly Cited
1981
Highly Cited
1981
Platelet function in hypertension and effect of therapy.
1981
1981
Nonnarcotic Antidiarrheal Action of Clonidine and Lofexidine in the Rat
Abstract: Clonidine (0.01 to 0.16 mg/kg) and lofexidine (0.01 to 0.64 mg/kg) produced a dose‐dependent inhibition of diarrhea… 
1981
1981
Opiate detoxification with lofexidine.
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