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lofexidine

Known as: 1H-imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-, 2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline, lofexidine [Chemical/Ingredient] 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (4)

Adrenergic alpha-2 Receptor AgonistsAntihypertensive AgentsClonidineNarcotic Antagonists

Narrower (1)

Britlofex
Lofexidine hydrochlorideanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
QT interval increased after single dose of lofexidine
Lofexidine (BritLofex, Britannia) is an α 2 agonist used for opioid detoxification.1 We report one case of an increased QT… 
2003
2003
The effectiveness of combined naloxone/lofexidine in opiate detoxification: results from a double-blind randomized and placebo-controlled trial.
The efficacy of lofexidine/naloxone was compared with lofexidine/placebo in a double-blind, randomized, placebo-controlled trial… 
2001
2001
The impact of naloxone/lofexidine combination treatment on the opiate withdrawal syndrome
Clinical studies in opiate‐dependent patients suggest that detoxification treatment with opiate antagonists may accelerate the… 
1999
1999
The Use of Lofexidine by Drug Dependency Units in the United Kingdom
Data were collected on 1,074 opiate detoxifications conducted with lofexidine, from 40 drug dependency units in the United… 
1999
1999
Hypo- and Hypersalivation Induced by Psychoactive Drugs
Psychoactive drugs can have profound effects on salivation: apart from affecting the amount of saliva secreted (i.e. causing… 
Highly Cited
1998
Highly Cited
1998
Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification.
1986
1986
Lofexidine in alcohol withdrawal states.
Twenty-eight patients admitted to hospital for alcohol withdrawal were treated with lofexidine, an alpha adrenergic agonist of… 
1983
1983
Opiate withdrawal using lofexidine, a clonidine analogue with fewer side effects.
In an open clinical trial, lofexidine, an alpha-noradrenergic agonist similar to clonidine, was administered to 30 opiate… 
1981
1981
Opiate detoxification with lofexidine.
1981
1981
Nonnarcotic Antidiarrheal Action of Clonidine and Lofexidine in the Rat
Abstract: Clonidine (0.01 to 0.16 mg/kg) and lofexidine (0.01 to 0.64 mg/kg) produced a dose‐dependent inhibition of diarrhea… 
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