lofexidine

Known as: 1H-imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-, 2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline, lofexidine [Chemical/Ingredient] 
 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (4)

Adrenergic alpha-2 Receptor AgonistsAntihypertensive AgentsClonidineNarcotic Antagonists

Narrower (1)

Britlofex
Lofexidine hydrochlorideanalogs & derivatives

Papers overview

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2009
2009
Electrocardiographic effects of lofexidine and methadone coadministration: secondary findings from a safety study.
STUDY OBJECTIVE To determine the electrocardiographic effects of coadministration of lofexidine and methadone. DESIGN… (More)
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Highly Cited
2007
Highly Cited
2007
Effects of THC and lofexidine in a human laboratory model of marijuana withdrawal and relapse
Individuals seeking treatment for their marijuana use rarely achieve sustained abstinence. The objectives of the study are to… (More)
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Highly Cited
2006
Highly Cited
2006
Effects of lofexidine on stress-induced and cue-induced opioid craving and opioid abstinence rates: preliminary findings
A preliminary study examined whether lofexidine decreases stress-induced and cue-induced opioid craving and improves opioid… (More)
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Highly Cited
2004
Highly Cited
2004
Role of alpha-2 adrenoceptors in stress-induced reinstatement of alcohol seeking and alcohol self-administration in rats
Alpha-2 adrenoceptors are known to be involved in stress-induced reinstatement of heroin and cocaine seeking in laboratory… (More)
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2002
2002
Prison based detoxification for opioid dependence: a randomised double blind controlled trial of lofexidine and methadone.
This paper reports results from the first controlled trial of opioid withdrawal treatment in the UK using lofexidine in a prison… (More)
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Highly Cited
2000
Highly Cited
2000
Alpha-2 Adrenergic Receptor Agonists Block Stress-Induced Reinstatement of Cocaine Seeking
The alpha-2 adrenergic receptor agonists, clonidine, lofexidine and guanabenz, blocked stress- but not cocaine-induced… (More)
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1998
1998
Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification.
This open study compares an accelerated 5-day lofexidine regimen with orthodox 10-day lofexidine and methadone regimens in the… (More)
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1997
1997
Double-blind randomised controlled trial of lofexidine versus clonidine in the treatment of heroin withdrawal.
Lofexidine is an analogue of clonidine, an agonist at the alpha 2 noradrenergic receptor. Reports from preliminary open studies… (More)
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1996
1996
Randomised double-blind comparison of lofexidine and methadone in the in-patient treatment of opiate withdrawal.
This study compares the clinical responses to methadone and lofexidine in the treatment of opiate withdrawal in 86 polydrug… (More)
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1985
1985
Alcohol withdrawal syndromes: clinical management with lofexidine.
Sixty-three mainly male alcoholics were randomly assigned to placebo or lofexidine treatment for 48 hr shortly after admission to… (More)
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