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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Prevalence of Takotsubo cardiomyopathy in the United States.
- A. Deshmukh, G. Kumar, S. Pant, C. Rihal, K. Murugiah, J. Mehta
- American heart journal
- 1 July 2012
TTC was diagnosed in about 0.02% of all hospitalizations in the United States, mostly in elderly women with history of smoking, alcohol abuse, anxiety states, and hyperlipidemia. Expand
Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients
A specific marker of human PMN-MDSC associated with ER stress and lipid metabolism is identified, which provides new insights into the biology and potential therapeutic targeting of these cells. Expand
Prevalence of coronary artery disease in Asian Indians.
Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders.
Recent studies show upregulation of LOX-1 in the ischemic-reperfused myocardium, and this receptor may be a novel, exciting target for drug therapy. Expand
Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: evidence from use of antisense LOX-1 mRNA and…
Findings indicate that ox-LDL upregulates its own endothelial receptor andmediated apoptosis of cultured human coronary artery endothelial cells (HCAECs) is mediated by the action of LOX-1. Expand
Oxidized LDL, LOX-1 and Atherosclerosis
The role of ox-LDL and LOX-1 in genesis and progression of atherosclerosis is discussed, which promotes the growth and migration of smooth muscle cells, monocytes/macrophages and fibroblasts. Expand
Deletion of LOX-1 Reduces Atherogenesis in LDLR Knockout Mice Fed High Cholesterol Diet
Generation of LOX-1 knockout mice in which binding of oxLDL to aortic endothelium was reduced and endothelia-dependent vasorelaxation preserved after treatment withOxLDL sustains endothelial function leading to a reduction in atherogenesis in association with reduction in proinflammatory and prooxidant signals. Expand
Role of Caspases in Ox-LDL–Induced Apoptotic Cascade in Human Coronary Artery Endothelial Cells
- Jiawei Chen, J. Mehta, Nezam Haider, X. Zhang, J. Narula, Dayuan Li
- Biology, Medicine
- Circulation research
- 20 February 2004
It is suggested that ox-LDL through its receptor LOX-1 decreases the expression of antiapoptotic proteins Bcl-2 and c-IAP-1, which are involved in the release of cytochrome c and Smac and activation of caspase-9, in a concentration- and time-dependent manner. Expand
Malignant coronary artery disease in young asian indians: Thoughts on pathogenesis, prevention, and therapy
Aggressive modification of life style beginning before adolescence seems justified in view of the malignant nature of CAD in this population, and Pharmacologic intervention similar to that of secondary prevention of CAD seems justified as primary prevention in high‐risk Asian Indians. Expand