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Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse
- R. S. Sohal, H. Ku, S. Agarwal, M. Forster, H. Lal
- Medicine, Biology
- Mechanisms of Ageing and Development
- 1 May 1994
Mechanisms of aging and life span shortening by enhanced caloric intake are associated with oxidative damage arising from corresponding changes in mitochondrial oxidant production and protein carbonyl content, and mitochondrial O2.- and H2O2 generation may act as indices of aging. Expand
Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse.
- A. Dubey, M. Forster, H. Lal, R. S. Sohal
- Biology, Medicine
- Archives of biochemistry and biophysics
- 1 September 1996
The findings suggest that the beneficial effects of dietary restriction upon brain function and life span may depend upon its ability to acutely reduce steady-state levels of oxidative stress. Expand
Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice
- R. S. Sohal, S. Agarwal, M. Candas, M. Forster, H. Lal
- Medicine, Chemistry
- Mechanisms of Ageing and Development
- 20 October 1994
The hypothesis that oxidative damage to long-lived post-mitotic cells may be a key factor in the aging process is supported, as the DR-related amelioration of DNA oxidative damage was greater in the post-Mitotic tissues compared to those undergoing slow mitoses. Expand
Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain.
- M. Forster, A. Dubey, K. Dawson, W. A. Stutts, H. Lal, R. S. Sohal
- Proceedings of the National Academy of Sciences…
- 14 May 1996
The results support the view that oxidative stress is a causal factor in brain senescence and suggest that age-related declines of cognitive and motor performance progress independently, and involve oxidative molecular damage within different regions of the brain. Expand
Anxiogenic properties of cocaine withdrawal.
Chronic administration of cocaine produced sensitization for the PTZ stimulus, tolerance developed to the behaviorally disruptive effects of cocaine, and cocaine withdrawal produced a PTZ-like stimulus which was blocked by diazepam. Expand
Anxiogenic behavior in rats during acute and protracted ethanol withdrawal: reversal by buspirone.
The results obtained in this study suggest that pharmacotherapy with selective 5-HT1A agonists may be beneficial in alleviation of anxiety during ethanol withdrawal. Expand
Enhancement of learning and memory in mice by a benzodiazepine antagonist
It is hypothesized that flumazenil may facilitate learning or memory processes by reversing a negative modulatory influence of endogenous diazepam‐like ligands for benzodiazepine receptors. Expand
Effects of ethanol and ethanol withdrawal on nociception in rats.
Ethanol produces antinociception when administered acutely or chronically; tolerance to the ant inociceptive effects develops during chronic administration; (3) ethanol withdrawal induced hyperalgesia, which was reversed by ethanol; and (4) repeated testing did not produce behavioral tolerance. Expand
Morphine-withdrawal aggression: Sensitization by amphetamines
Aggressive behaviors during the withdrawal from morphine sulfate, were potentiated by methylphenidate or d and l isomers of amphetamine, while hydroxyamphetamine was without any effect. Expand
Characterization of a pentylenetetrazol-like interoceptive stimulus produced by ethanol withdrawal.
- H. Lal, C. Harris, D. Benjamin, A. Springfield, S. Bhadra, M. Emmett-Oglesby
- The Journal of pharmacology and experimental…
- 1 November 1988
The results indicate that a PTZ-like stimulus produced interoceptively can be demonstrated in the rat as an objective measure of ethanol withdrawal, and may provide insight into the symptom of anxiety associated with ethanol withdrawal. Expand