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Evidence that the discriminative stimulus properties of fentanyl and ethylketocyclazocine are mediated by an interaction with different opiate receptors.
Partial dopamine-agonistic and atypical neuroleptic properties of the amino-ergolines SDZ 208-911 and SDZ 208-912.
- D. Coward, A. Dixon, +4 authors G. Shearman
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
SDZ 208-911 and 208-912 could be effective against both the positive and negative symptoms of schizophrenia, while exhibiting a reduced incidence of dystonic and parkinsonian side-effects, and might throw more light on the central dopaminergic status of schizophrenic subjects. Expand
Discriminative stimulus properties of cocaine related to an anxiogenic action.
The data suggest that cocaine produces discriminative stimulus that is related to its anxiogenic action, and Diazepam but not haloperidol significantly antagonized the discrim inative stimuli produced by pentylenetetrazol and cocaine. Expand
Mixed opioid/nonopioid effects of dynorphin and dynorphin related peptides after their intrathecal injection in rats
It was found that dynorphin was approximately ten times more potent in producing its effects when injected one day after surgery compared to when it was injected one week or more after surgery. Expand
Non-opioid psychotomimetic-like discriminative stimulus properties of N-allylnormetazocine (SKF 10,047) in the rat.
The data suggest that the discriminative stimulus property of dl-SKF 10,047 in the rat is not due to its interaction with either opiate receptors or dopaminergic mechanisms but may be related to its psychotomimetic effect in man. Expand
The noncompetitive N-methyl-d-aspartate receptor antagonist, MK-801 profoundly reduces volatile anesthetic requirements in rabbits
- M. Scheller, M. Zornow, J. E. Fleischer, G. Shearman, T. Greber
- Medicine, Chemistry
- 1 July 1989
It was demonstrated that MK-801 significantly reduced anesthetic requirements in a dose-dependent manner, while also affecting hemodynamics and the electroencephalogram in a manner consistent with the production of a deeper plane of anesthesia. Expand
MK-801, an Excitatory Amino Acid Antagonist, Does Not Improve Neurologic Outcome following Cardiac Arrest in Cats
- J. E. Fleischer, A. Tateishi, +5 authors H. Shapiro
- Journal of cerebral blood flow and metabolism…
- 1 December 1989
In the circumstance of complete cerebral ischemia as employed in the current study, MK-801 had no beneficial effect upon neurologic or neuropathologic outcome. Expand
Partial brain dopamine D2 receptor agonists in the treatment of schizophrenia.
Partial dopamine agonists showing high affinity but low efficacy at D2 receptors can act as dopaminergic "buffers," reducing dopaminergic activity when it is excessive, and promoting it when reduced.… Expand
Effectiveness of lofexidine in blocking morphine-withdrawal signs in the rat
The data suggest that lofexidine, like clonidine, may reduce the narcotic withdrawal syndrome in humans. Expand
Discriminative stimulus properties of pentylenetetrazol and bemegride: Some generalization and antagonism tests
The anxiolytic properties of benzodiazepines and meprobamate suggest that the discriminative stimulus produced by these convulsants is related to an “anxiety-inducing” action. Expand