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lapatinib

Known as: N-(3-chloro-4-(((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-methylsulfonyl)ethyl)amino)methyl) -2-furyl)-4-quinazolinamine, N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine, lapatinib [Chemical/Ingredient] 
A synthetic, orally-active quinazoline with potential antineoplastic properties. Lapatinib reversibly blocks phosphorylation of the epidermal growth… 
National Institutes of Health

Related topics

Related topics

17 relations

Broader (3)

Antineoplastic AgentsProtein Kinase InhibitorsQuinazolines
EGFR protein, humanERBB2 protein, humanInhibition of Cell ProliferationNCIt Antineoplastic Agent Terminology

Narrower (5)

GW 282974XGW 572016GW2016Tykerb

Papers overview

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Highly Cited
2011
Highly Cited
2011
Inhibitor of Apoptosis (IAP) survivin is indispensable for survival of HER2 gene-amplified breast cancer cells with primary resistance to HER1/2-targeted therapies.
2011
2011
A Scalable Parallel Wideband MLFMA for Efficient Electromagnetic Simulations on Large Scale Clusters
The development of the multilevel fast multipole algorithm (MLFMA) and its multiscale variants have enabled the use of integral… 
2010
2010
Estimating Unknown Clutter Intensity for PHD Filter
In most of the existing probability hypothesis density (PHD) filters, the clutter is modeled as a Poisson random finite set (RFS… 
Highly Cited
2009
Highly Cited
2009
Inhibition of MCL-1 enhances Lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy
Prior studies demonstrated that resistance to the ERBB1/2 inhibitor Lapatinib in HCT116 cells was mediated by increased MCL-1… 
Review
2009
Review
2009
Anthracycline- and/or taxane-resistant breast cancer: results of a literature review to determine the clinical challenges and current treatment trends.
Highly Cited
2009
Highly Cited
2009
STUDY ON EM SCATTERING FROM 2-D TARGET ABOVE 1-D LARGE SCALE ROUGH SURFACE WITH LOW GRAZING INCIDENCE BY PARALLEL MOM BASED ON PC CLUSTERS
Abstract—Based on message passing interface (MPI) of the PC Clusters, the parallel method of moment (MOM) is applied to the… 
Highly Cited
2009
Highly Cited
2009
Phase I study of lapatinib in combination with chemoradiation in patients with locally advanced squamous cell carcinoma of the head and neck.
PURPOSE This study (EGF100262) sought to establish the recommended phase II dose of lapatinib with chemoradiotherapy in patients… 
2009
2009
Calculation of femtosecond pulse laser induced damage threshold for broadband antireflective microstructure arrays.
In order to more exactly predict femtosecond pulse laser induced damage threshold, an accurate theoretical model taking into… 
Highly Cited
2008
Highly Cited
2008
Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation
We have defined some of the mechanisms by which the kinase inhibitor lapatinib kills HCT116 cells. Lapatinib inhibited radiation… 
Highly Cited
2002
Highly Cited
2002
First isolation of Flexibacter maritimus from farmed Senegalese sole (Solea senegalensis, Kaup) in Spain
The present study deals with the first isolation of Flexibacter maritimus from Senegalese sole, Solea senegalensis (Kaup… 
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