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lapatinib
Known as:
N-(3-chloro-4-(((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-methylsulfonyl)ethyl)amino)methyl) -2-furyl)-4-quinazolinamine
, N-(3-chloro-4-((3-Fluorophenyl)methoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine
, lapatinib [Chemical/Ingredient]
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A synthetic, orally-active quinazoline with potential antineoplastic properties. Lapatinib reversibly blocks phosphorylation of the epidermal growth…
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National Institutes of Health
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Related topics
Related topics
17 relations
Broader (3)
Antineoplastic Agents
Protein Kinase Inhibitors
Quinazolines
EGFR protein, human
ERBB2 protein, human
Inhibition of Cell Proliferation
NCIt Antineoplastic Agent Terminology
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Narrower (5)
GW 282974X
GW 572016
GW2016
Tykerb
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Inhibitor of Apoptosis (IAP) survivin is indispensable for survival of HER2 gene-amplified breast cancer cells with primary resistance to HER1/2-targeted therapies.
C. Oliveras‐Ferraros
,
A. Vázquez-Martín
,
+7 authors
J. Menéndez
Biochemical and Biophysical Research…
2011
Corpus ID: 5057697
2011
2011
A Scalable Parallel Wideband MLFMA for Efficient Electromagnetic Simulations on Large Scale Clusters
V. Melapudi
,
Balasubramaniam Shanker
,
S. Seal
,
Srinivas Aluru
IEEE Transactions on Antennas and Propagation
2011
Corpus ID: 26576205
The development of the multilevel fast multipole algorithm (MLFMA) and its multiscale variants have enabled the use of integral…
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2010
2010
Estimating Unknown Clutter Intensity for PHD Filter
Feng Lian
,
Chongzhao Han
,
Weifeng Liu
IEEE Transactions on Aerospace and Electronic…
2010
Corpus ID: 41850739
In most of the existing probability hypothesis density (PHD) filters, the clutter is modeled as a Poisson random finite set (RFS…
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Highly Cited
2009
Highly Cited
2009
Inhibition of MCL-1 enhances Lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy
Aditi Pandya Martin
,
Clint Mitchell
,
M. Rahmani
,
K. Nephew
,
S. Grant
,
P. Dent
Cancer Biology & Therapy
2009
Corpus ID: 31855007
Prior studies demonstrated that resistance to the ERBB1/2 inhibitor Lapatinib in HCT116 cells was mediated by increased MCL-1…
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Review
2009
Review
2009
Anthracycline- and/or taxane-resistant breast cancer: results of a literature review to determine the clinical challenges and current treatment trends.
A. Moreno-Aspitia
,
E. Perez
Clinical Therapeutics
2009
Corpus ID: 36817102
Highly Cited
2009
Highly Cited
2009
STUDY ON EM SCATTERING FROM 2-D TARGET ABOVE 1-D LARGE SCALE ROUGH SURFACE WITH LOW GRAZING INCIDENCE BY PARALLEL MOM BASED ON PC CLUSTERS
Li-xin Guo
,
An-qi Wang
,
Jun Ma
2009
Corpus ID: 55276791
Abstract—Based on message passing interface (MPI) of the PC Clusters, the parallel method of moment (MOM) is applied to the…
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Highly Cited
2009
Highly Cited
2009
Phase I study of lapatinib in combination with chemoradiation in patients with locally advanced squamous cell carcinoma of the head and neck.
K. Harrington
,
I. El‐Hariry
,
+10 authors
J. Bourhis
Journal of Clinical Oncology
2009
Corpus ID: 34263970
PURPOSE This study (EGF100262) sought to establish the recommended phase II dose of lapatinib with chemoradiotherapy in patients…
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2009
2009
Calculation of femtosecond pulse laser induced damage threshold for broadband antireflective microstructure arrays.
Xufeng Jing
,
J. Shao
,
Junchao Zhang
,
Yunxia Jin
,
Hongbo He
,
Z. Fan
Optics Express
2009
Corpus ID: 207313790
In order to more exactly predict femtosecond pulse laser induced damage threshold, an accurate theoretical model taking into…
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Highly Cited
2008
Highly Cited
2008
Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation
A. P. Martin
,
A. Miller
,
+9 authors
P. Dent
Molecular Pharmacology
2008
Corpus ID: 14042347
We have defined some of the mechanisms by which the kinase inhibitor lapatinib kills HCT116 cells. Lapatinib inhibited radiation…
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Highly Cited
2002
Highly Cited
2002
First isolation of Flexibacter maritimus from farmed Senegalese sole (Solea senegalensis, Kaup) in Spain
C. Cepeda
,
Y. Santos
2002
Corpus ID: 51855629
The present study deals with the first isolation of Flexibacter maritimus from Senegalese sole, Solea senegalensis (Kaup…
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