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GW 572016

Known as: GW-572016, GW572016 
 
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Background: Lapatinib (GW572016) is a dual tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR) and human… Expand
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Highly Cited
2009
Highly Cited
2009
PurposeWe undertook a phase I/II study of the EGFR/erbB2 inhibitor lapatinib in patients with recurrent glioblastoma multiforme… Expand
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Highly Cited
2008
Highly Cited
2008
Lapatinib is active at the ATP-binding site of tyrosine kinases that are associated with the human epidermal growth factor… Expand
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Highly Cited
2008
Highly Cited
2008
Lapatinib [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine… Expand
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE Lapatinib (Tykerb, GW572016), a potent inhibitor of the catalytic activities of epidermal growth factor receptor (EGFR… Expand
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Highly Cited
2006
Highly Cited
2006
Lapatinib (GW572016) is a selective inhibitor of both epidermal growth factor receptor (EGFR) and HER-2 tyrosine kinases. Here… Expand
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Highly Cited
2005
Highly Cited
2005
Antibodies and small molecule tyrosine kinase inhibitors targeting ErbB2 exhibit distinct, noncross resistant mechanisms of… Expand
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Highly Cited
2005
Highly Cited
2005
Effective treatment of estrogen receptor (ER)-positive breast cancers with tamoxifen is often curtailed by the development of… Expand
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Highly Cited
2004
Highly Cited
2004
GW572016 (Lapatinib) is a tyrosine kinase inhibitor in clinical development for cancer that is a potent dual inhibitor of… Expand
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Highly Cited
2004
Highly Cited
2004
The expression of the NH2 terminally truncated ErbB2 receptor (p95ErbB2) in breast cancer correlates with metastatic disease… Expand
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