Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Hedgehog signaling inhibitors should be used in combination with RTK inhibitors, GPCR modulators, and/or irradiation for cancer therapy.
FGF Receptors: Cancer Biology and Therapeutics
- M. Katoh, H. Nakagama
- Biology, MedicineMedicinal research reviews (Print)
- 1 March 2014
Whole exome/transcriptome sequencing will be introduced to the clinical laboratory as the companion diagnostic platform facilitating patient selection for FGFR‐targeted therapeutics in the era of personalized medicine.
WNT/PCP signaling pathway and human cancer (review).
- M. Katoh
- BiologyOncology Report
- 1 December 2005
Aberrant activation of WNT/PCP signaling pathway in human cancer leads to more malignant phenotypes, such as abnormal tissue polarity, invasion, and metastasis, which could be developed as novel cancer prognostics.
Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review).
Hedgehog signaling activation indirectly leads to EMT through FGF, Notch, TGFbeta signaling cascades, and miRNA regulatory networks.
Fibroblast growth factor receptors as treatment targets in clinical oncology
- M. Katoh
- Biology, MedicineNature Reviews Clinical Oncology
- 26 October 2018
The clinical experience with FGFR inhibitors to date is described, and key aspects that might lead to improved response rates and/or the avoidance of acquired resistance are highlighted, including the selection of patients who are most likely to benefit from treatment, and the use ofFGFR inhibitors in combination regimens with other agents.
WNT Signaling Pathway and Stem Cell Signaling Network
- Masuko Katoh, M. Katoh
- BiologyClinical Cancer Research
- 15 July 2007
WNT signals are context-dependently transduced to both pathways based on the expression profile of WNT, SFRP, WIF, DKK, Frizzled receptors, coreceptors, and the activity of intracellular WNT signaling regulators.
Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)
- M. Katoh
- BiologyInternational Journal of Oncology
- 19 September 2017
Aberrant canonical and non-canonical WNT signaling in human malignancies, including breast, colorectal, gastric, lung, ovary, pancreatic, prostate and uterine cancers, leukemia and melanoma, are involved in CSC survival, bulk-tumor expansion and invasion/metastasis.
Tissue invasion and metastasis: Molecular, biological and clinical perspectives.
- W. Jiang, A. Sanders, D. Santini
- BiologySeminars in Cancer Biology
- 1 December 2015
Human FOX gene family (Review).
- Masuko Katoh, M. Katoh
- BiologyInternational Journal of Oncology
- 1 November 2004
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1, FOXD2, FOXD3, FOXD4, FOXD5 (FOXD4L1), FOXD6 (FOXD4L3), FOXE1, FOXE2,…
Functional and cancer genomics of ASXL family members
- M. Katoh
- Biology, MedicineBritish Journal of Cancer
- 4 June 2013
Additional sex combs-like (ASXL)1, ASXL2 and ASXL3 are human homologues of the Drosophila Asx gene that are involved in the regulation or recruitment of the Polycomb-group repressor complex (PRC) and…
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