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lapatinib ditosylate

The ditosylate salt of lapatinib, a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks… 
National Institutes of Health

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EGFR protein, humanERBB2 protein, humanInhibition of Cell ProliferationPhosphorylation Inhibition

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GW 572016GW2016Tykerb

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lapatinib

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Mechanisms of resistance to T-DM1 in HER2-positive breast cancer
El cancer de mama HER2-positivo representa alrededor del 15-30% del total de pacientes con cancer de mama. Este subtipo tiene un… 
2017
2017
Efficacia della combinazione lapatinib-capecitabina in una paziente con carcinoma mammario HER2-positivo metastatico e con resistenza primaria a due linee di terapia con agenti anti-HER2
La sovraespressione dell’oncoproteina HER2 (human epidermal growth factor receptor 2), spesso sostenuta dall’amplificazione del… 
2015
2015
Lapatinib nel tumore mammario metastatico HER2-positivo: suggerimenti dall’ Esmo 2014
2015
2015
Preparing method of lapatinib and preparing method of lapatinib ditosylate
The invention provides a preparing method of lapatinib. The preparing method includes the steps that under nitrogen protection, a… 
2015
2015
Lapatinib versus lapatinib plus capecitabine as second-line treatment in HER-2-overexpressing metastatic gastro-esophageal cancer (GC): A randomized phase II trial of the Arbeitsgemeinschaft…
112 Background: HER2 amplification is present in a subgroup of gastroesophageal cancers (GCs). HER2 inhibition with trastuzumab… 
2012
2012
Polymorph 4- (substituted anilino) quinazoline ditosylate salt of the derivative and preparation method and use
本发明涉及作为酪氨酸激酶抑制剂N-(4-(3-氟苄氧基)-3-氯苯基)-6-(5-((2-(甲基亚砜基)乙基氨基)甲基)-2-呋喃基)-喹唑啉-4-胺二甲苯磺酸盐(化合物I)的多晶型物。 具体而言，本发明涉及化合物I的晶型A、B、C和D… 
2012
2012
Poly-crystal-form substance of lapatinib ditosylate solvate as well as preparation method and application thereof
The invention discloses a poly-crystal-form substance of lapatinib ditosylate solvate as well as a preparation method and… 
2010
2010
Safety and tolerability of lapatinib ditosylate given concurrently with docetaxel, carboplatin, and trastuzumab (TCHL) as part of adjuvant therapy for patients with HER2+ breast cancer: Pilot data…
565 Background: The nonanthracycline regimen of docetaxel (T), carboplatin (C), and trastuzumab (H) is available for patients… 
2010
2010
Ruolo del Lapatinib nel trattamento adiuvante del carcinoma mammario HER-2 positivo
Aim: HER2 receptor is a molecular target for breast cancer therapy. Two drugs acts against this receptor: Trastuzumab, a… 
Review
2007
Review
2007
A review of lapatinib ditosylate in the treatment of refractory or advanced breast cancer
Breast cancer remains a leading cause of disease and death among women throughout the world. Despite advances in drug therapy… 
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