Tykerb

 

Topic mentions per year

Topic mentions per year

2006-2016
051020062016

Papers overview

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2012
2012
Lapatinib (Tykerb, Tyverb) is an important orally active dual tyrosine kinase inhibitor efficacious in combination therapy for… (More)
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2010
2010
In July this year, Genentech submitted a biologic license application to the US Food and Drug Administration (FDA) for the… (More)
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2010
2010
Fatalities stemming from hepatotoxicity associated with the clinical use of lapatinib (Tykerb), an oral dual tyrosine kinase… (More)
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2010
2010
In recent years, a number of TKIs (tyrosine kinase inhibitors) targeting epidermal growth factor receptor (EGFR) family have been… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE Oncogenic activation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway is prevalent in breast cancer and has… (More)
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Highly Cited
2008
Highly Cited
2008
Lapatinib is active at the ATP-binding site of tyrosine kinases that are associated with the human epidermal growth factor… (More)
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Highly Cited
2008
Highly Cited
2008
Lapatinib [N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine… (More)
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Highly Cited
2008
Highly Cited
2008
OBJECTIVES More than 50 years ago, we learned that breast cancer cells (and those of many other types of tumour) endogenously… (More)
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2008
2008
Lapatinib is active at the ATP-binding site of tyrosine kinases that are associated with the human epidermal growth factor… (More)
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE Lapatinib (Tykerb, GW572016), a potent inhibitor of the catalytic activities of epidermal growth factor receptor (EGFR… (More)
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