isoniazid

Known as: Pyridine-4-carboxylic acid hydrazide, INH, Isonicotinic Acid Hydrazide 
A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to… (More)
National Institutes of Health

Related topics

Related topics

45 relations

Narrower (23)

1-isonicotinyl-2-lactosylhydrazine1-isonicotinyl-2-nonanoyl hydrazine2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazoneDBDY-(Gly-INH)2
(More)
4-pyridinecarbohydrazideAntimycobacterial agentDrug toxicityIn Blood
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Broader (6)

Antitubercular AgentsEthersFatty Acid Synthesis InhibitorsHydrazine
(More)

Papers overview

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Highly Cited
2011
Highly Cited
2011
Three months of rifapentine and isoniazid for latent tuberculosis infection.
BACKGROUND Treatment of latent Mycobacterium tuberculosis infection is an essential component of tuberculosis control and… (More)
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Highly Cited
2011
Highly Cited
2011
6-month versus 36-month isoniazid preventive treatment for tuberculosis in adults with HIV infection in Botswana: a randomised, double-blind, placebo-controlled trial
BACKGROUND In accordance with WHO guidelines, people with HIV infection in Botswana receive daily isoniazid preventive therapy… (More)
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Highly Cited
2009
Highly Cited
2009
Substitution of moxifloxacin for isoniazid during intensive phase treatment of pulmonary tuberculosis.
RATIONALE Moxifloxacin has potent activity against Mycobacterium tuberculosis in vitro and in a mouse model of antituberculosis… (More)
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Highly Cited
2006
Highly Cited
2006
Population genetics study of isoniazid resistance mutations and evolution of multidrug-resistant Mycobacterium tuberculosis.
The molecular basis for isoniazid resistance in Mycobacterium tuberculosis is complex. Putative isoniazid resistance mutations… (More)
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Highly Cited
2003
Highly Cited
2003
Low isoniazid concentrations and outcome of tuberculosis treatment with once-weekly isoniazid and rifapentine.
To understand why once-weekly isoniazid/rifapentine therapy for tuberculosis was less effective than twice-weekly isoniazid… (More)
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Highly Cited
1996
Highly Cited
1996
Risk factors for side-effects of isoniazid, rifampin and pyrazinamide in patients hospitalized for pulmonary tuberculosis.
The aim of this study was to determine the current incidence of side-effects severe enough to cause intolerance of standard… (More)
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Highly Cited
1994
Highly Cited
1994
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.
Isoniazid (isonicotinic acid hydrazide, INH) is one of the most widely used antituberculosis drugs, yet its precise target of… (More)
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Highly Cited
1992
Highly Cited
1992
The catalase—peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis
TUBERCULOSIS is responsible for one in four of all avoidable adult deaths in developing countries1. Increased frequency and… (More)
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Highly Cited
1979
Highly Cited
1979
Isoniazid prophylaxis among Alaskan Eskimos: a final report of the bethel isoniazid studies.
As a result of numerous trials, isoniazid prophylaxis was shown to be effective in preventing tuberculosis in many different… (More)
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Highly Cited
1974
Highly Cited
1974
The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites.
With a stepwise degradation and terminal labeling procedure the 3'-terminal sequence of E. coli 16S ribosomal RNA is shown to be… (More)
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