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isoniazid

Known as: Pyridine-4-carboxylic acid hydrazide, INH, Isonicotinic Acid Hydrazide 
A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
The burden of isoniazid-resistant tuberculosis (Hr-TB) and multidrugand/or rifampicin monoresistant tuberculosis (MDR/RR-TB) is… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND In sub-Saharan Africa, the burden of human immunodeficiency virus (HIV)-associated tuberculosis is high. We conducted… Expand
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Treatment of latent Mycobacterium tuberculosis infection is an essential component of tuberculosis control and… Expand
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Highly Cited
1998
Highly Cited
1998
The preferred antitubercular drug isoniazid specifically targets a long-chain enoyl-acyl carrier protein reductase (InhA), an… Expand
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Highly Cited
1996
Highly Cited
1996
Mutations that eliminate KatG catalase-peroxidase activity prevent activation of isoniazid and are a major mechanism of… Expand
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Highly Cited
1994
Highly Cited
1994
Isoniazid (isonicotinic acid hydrazide, INH) is one of the most widely used antituberculosis drugs, yet its precise target of… Expand
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Highly Cited
1992
Highly Cited
1992
TUBERCULOSIS is responsible for one in four of all avoidable adult deaths in developing countries1. Increased frequency and… Expand
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Highly Cited
1990
Highly Cited
1990
Diagnostic Criteria of Nontuberculous Mycobacterial Lung Disease For patients with a cavitary infiltrate: Two or more sputums or… Expand
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Highly Cited
1974
Highly Cited
1974
With a stepwise degradation and terminal labeling procedure the 3'-terminal sequence of E. coli 16S ribosomal RNA is shown to be… Expand
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Highly Cited
1960
Highly Cited
1960
collars limits their use to some extent" (Lancet, 1958). It has also been suggested that conservative treatment should not… Expand
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