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isoniazid

Known as: Pyridine-4-carboxylic acid hydrazide, INH, Isonicotinic Acid Hydrazide 
A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to… Expand
National Institutes of Health

Related topics

Related topics

44 relations

Narrower (22)

1-isonicotinyl-2-lactosylhydrazine1-isonicotinyl-2-nonanoyl hydrazineBT 103DBDY-(Gly-INH)2
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4-pyridinecarbohydrazideDrug toxicityIn BloodIsoniazid:ACnc:Pt:Ser/Plas:Qn
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Broader (6)

Antitubercular AgentsEthersFatty Acid Synthesis InhibitorsHydrazine
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
What is new in the WHO consolidated guidelines on drug-resistant tuberculosis treatment?
The burden of isoniazid-resistant tuberculosis (Hr-TB) and multidrugand/or rifampicin monoresistant tuberculosis (MDR/RR-TB) is… Expand
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Highly Cited
2015
Highly Cited
2015
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
BACKGROUND In sub-Saharan Africa, the burden of human immunodeficiency virus (HIV)-associated tuberculosis is high. We conducted… Expand
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Highly Cited
2011
Highly Cited
2011
Three months of rifapentine and isoniazid for latent tuberculosis infection.
BACKGROUND Treatment of latent Mycobacterium tuberculosis infection is an essential component of tuberculosis control and… Expand
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Highly Cited
1998
Highly Cited
1998
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
The preferred antitubercular drug isoniazid specifically targets a long-chain enoyl-acyl carrier protein reductase (InhA), an… Expand
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Highly Cited
1996
Highly Cited
1996
Compensatory ahpC Gene Expression in Isoniazid-Resistant Mycobacterium tuberculosis
Mutations that eliminate KatG catalase-peroxidase activity prevent activation of isoniazid and are a major mechanism of… Expand
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Highly Cited
1994
Highly Cited
1994
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.
Isoniazid (isonicotinic acid hydrazide, INH) is one of the most widely used antituberculosis drugs, yet its precise target of… Expand
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Highly Cited
1992
Highly Cited
1992
The catalase—peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis
TUBERCULOSIS is responsible for one in four of all avoidable adult deaths in developing countries1. Increased frequency and… Expand
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Highly Cited
1990
Highly Cited
1990
Diagnosis and treatment of disease caused by nontuberculous mycobacteria.
Diagnostic Criteria of Nontuberculous Mycobacterial Lung Disease For patients with a cavitary infiltrate: Two or more sputums or… Expand
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Highly Cited
1974
Highly Cited
1974
The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites.
With a stepwise degradation and terminal labeling procedure the 3'-terminal sequence of E. coli 16S ribosomal RNA is shown to be… Expand
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Highly Cited
1960
Highly Cited
1960
Genetic Control of Isoniazid Metabolism in Man
collars limits their use to some extent" (Lancet, 1958). It has also been suggested that conservative treatment should not… Expand
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