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isoniazid

Known as: Pyridine-4-carboxylic acid hydrazide, INH, Isonicotinic Acid Hydrazide 
A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to… Expand
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
BACKGROUND In sub-Saharan Africa, the burden of human immunodeficiency virus (HIV)-associated tuberculosis is high. We conducted… Expand
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Treatment of latent Mycobacterium tuberculosis infection is an essential component of tuberculosis control and… Expand
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Highly Cited
1998
Highly Cited
1998
The preferred antitubercular drug isoniazid specifically targets a long-chain enoyl-acyl carrier protein reductase (InhA), an… Expand
Highly Cited
1994
Highly Cited
1994
Isoniazid (isonicotinic acid hydrazide, INH) is one of the most widely used antituberculosis drugs, yet its precise target of… Expand
Highly Cited
1992
Highly Cited
1992
TUBERCULOSIS is responsible for one in four of all avoidable adult deaths in developing countries1. Increased frequency and… Expand
Highly Cited
1991
Highly Cited
1991
ALT = serum alanine aminotransferase; AST serum aspartate aminotransferase; BIU bilirubin; EMB ethambutol; INH isoniazid; NSM not… Expand
Highly Cited
1990
Highly Cited
1990
Diagnostic Criteria of Nontuberculous Mycobacterial Lung Disease For patients with a cavitary infiltrate: Two or more sputums or… Expand
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Review
1976
Review
1976
The clinical spectrum of isoniazid-induced liver injury seems to be clinically, biochemically, and histologically… Expand
Highly Cited
1974
Highly Cited
1974
With a stepwise degradation and terminal labeling procedure the 3'-terminal sequence of E. coli 16S ribosomal RNA is shown to be… Expand
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Highly Cited
1960
Highly Cited
1960
collars limits their use to some extent" (Lancet, 1958). It has also been suggested that conservative treatment should not… Expand