isoniazid

Known as: Pyridine-4-carboxylic acid hydrazide, INH, Isonicotinic Acid Hydrazide 
A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to… (More)
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
BACKGROUND Treatment of latent Mycobacterium tuberculosis infection is an essential component of tuberculosis control and… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND In accordance with WHO guidelines, people with HIV infection in Botswana receive daily isoniazid preventive therapy… (More)
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Highly Cited
2009
Highly Cited
2009
RATIONALE Moxifloxacin has potent activity against Mycobacterium tuberculosis in vitro and in a mouse model of antituberculosis… (More)
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Highly Cited
2006
Highly Cited
2006
The molecular basis for isoniazid resistance in Mycobacterium tuberculosis is complex. Putative isoniazid resistance mutations… (More)
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Highly Cited
2003
Highly Cited
2003
To understand why once-weekly isoniazid/rifapentine therapy for tuberculosis was less effective than twice-weekly isoniazid… (More)
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Highly Cited
1996
Highly Cited
1996
The aim of this study was to determine the current incidence of side-effects severe enough to cause intolerance of standard… (More)
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Highly Cited
1994
Highly Cited
1994
Isoniazid (isonicotinic acid hydrazide, INH) is one of the most widely used antituberculosis drugs, yet its precise target of… (More)
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Highly Cited
1992
Highly Cited
1992
TUBERCULOSIS is responsible for one in four of all avoidable adult deaths in developing countries1. Increased frequency and… (More)
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Highly Cited
1979
Highly Cited
1979
As a result of numerous trials, isoniazid prophylaxis was shown to be effective in preventing tuberculosis in many different… (More)
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Highly Cited
1974
Highly Cited
1974
With a stepwise degradation and terminal labeling procedure the 3'-terminal sequence of E. coli 16S ribosomal RNA is shown to be… (More)
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