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isoniazid
Known as:
Pyridine-4-carboxylic acid hydrazide
, INH
, Isonicotinic Acid Hydrazide
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A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to…
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National Institutes of Health
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Related topics
Related topics
44 relations
Narrower (22)
1-isonicotinyl-2-lactosylhydrazine
1-isonicotinyl-2-nonanoyl hydrazine
BT 103
DBDY-(Gly-INH)2
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4-pyridinecarbohydrazide
Drug toxicity
In Blood
Isoniazid:ACnc:Pt:Ser/Plas:Qn
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Broader (6)
Antitubercular Agents
Ethers
Fatty Acid Synthesis Inhibitors
Hydrazine
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
A Trial of Early Antiretrovirals and Isoniazid Preventive Therapy in Africa.
C. Danel
,
R. Moh
,
+88 authors
X. Anglaret
New England Journal of Medicine
2015
Corpus ID: 5492565
BACKGROUND In sub-Saharan Africa, the burden of human immunodeficiency virus (HIV)-associated tuberculosis is high. We conducted…
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Highly Cited
2011
Highly Cited
2011
Three months of rifapentine and isoniazid for latent tuberculosis infection.
T. Sterling
,
M. Villarino
,
+14 authors
R. Chaisson
New England Journal of Medicine
2011
Corpus ID: 36515489
BACKGROUND Treatment of latent Mycobacterium tuberculosis infection is an essential component of tuberculosis control and…
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Highly Cited
2002
Highly Cited
2002
The diagnosis and management of
G. Thwaites
2002
Corpus ID: 73816006
Highly Cited
1998
Highly Cited
1998
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
D. A. Rozwarski
,
G. A. Grant
,
D. H. Barton
,
W. Jacobs
,
J. Sacchettini
Science
1998
Corpus ID: 39726097
The preferred antitubercular drug isoniazid specifically targets a long-chain enoyl-acyl carrier protein reductase (InhA), an…
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Highly Cited
1994
Highly Cited
1994
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.
A. Banerjee
,
E. Dubnau
,
+6 authors
W. Jacobs
Science
1994
Corpus ID: 1619858
Isoniazid (isonicotinic acid hydrazide, INH) is one of the most widely used antituberculosis drugs, yet its precise target of…
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Highly Cited
1992
Highly Cited
1992
The catalase—peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis
Ying Zhang
,
B. Heym
,
B. Allen
,
D. Young
,
S. Cole
Nature
1992
Corpus ID: 4366763
TUBERCULOSIS is responsible for one in four of all avoidable adult deaths in developing countries1. Increased frequency and…
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Highly Cited
1990
Highly Cited
1990
Diagnosis and treatment of disease caused by nontuberculous mycobacteria.
R. Wallace,
,
R. O'Brien
,
J. Glassroth
,
J. Raleigh
,
A. Dutt
American Review of Respiratory Disease
1990
Corpus ID: 13562267
Diagnostic Criteria of Nontuberculous Mycobacterial Lung Disease For patients with a cavitary infiltrate: Two or more sputums or…
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Review
1976
Review
1976
Isoniazid liver injury: clinical spectrum, pathology, and probable pathogenesis.
J. Mitchell
,
H. Zimmerman
,
+4 authors
S. Nelson
Annals of Internal Medicine
1976
Corpus ID: 23052711
The clinical spectrum of isoniazid-induced liver injury seems to be clinically, biochemically, and histologically…
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Highly Cited
1974
Highly Cited
1974
The 3'-terminal sequence of Escherichia coli 16S ribosomal RNA: complementarity to nonsense triplets and ribosome binding sites.
J. Shine
,
L. Dalgarno
Proceedings of the National Academy of Sciences…
1974
Corpus ID: 5384066
With a stepwise degradation and terminal labeling procedure the 3'-terminal sequence of E. coli 16S ribosomal RNA is shown to be…
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Highly Cited
1960
Highly Cited
1960
Genetic Control of Isoniazid Metabolism in Man
D. Evans
,
K. A. Manley
,
V. McKusick
British medical journal
1960
Corpus ID: 33775948
collars limits their use to some extent" (Lancet, 1958). It has also been suggested that conservative treatment should not…
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