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- Publications
- Influence
Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck.
- W. Hong, S. Lippman, +7 authors L. Peters
- Medicine
- The New England journal of medicine
- 20 September 1990
BACKGROUND
Patients with head-and-neck cancers who are free of disease after local therapy remain at high risk for both recurrent and second primary tumors. Retinoids have proved efficacious in the… Expand
International Union of Pharmacology. LX. Retinoic Acid Receptors
- P. Germain, P. Chambon, +7 authors H. Gronemeyer
- Biology, Medicine
- Pharmacological Reviews
- 1 December 2006
Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARα, RARβ, and RARγ), members of the nuclear hormone receptor superfamily. The most important endogenous retinoid… Expand
International Union of Pharmacology. LXIII. Retinoid X Receptors
- P. Germain, P. Chambon, +7 authors H. Gronemeyer
- Biology, Medicine
- Pharmacological Reviews
- 1 December 2006
The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are… Expand
Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles.
- K. Sokolov, M. Follen, +4 authors R. Richards-Kortum
- Chemistry, Medicine
- Cancer research
- 1 May 2003
Recent developments in photonic technology provide the ability to noninvasively image cells in vivo; these new cellular imaging technologies have the potential to dramatically improve the prevention,… Expand
Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells.
- R. Lotan
- Medicine
- Biochimica et biophysica acta
- 12 March 1980
Predicting cancer development in oral leukoplakia: ten years of translational research.
- J. Lee, W. Hong, +12 authors S. Lippman
- Medicine
- Clinical cancer research : an official journal of…
- 1 May 2000
Our 10-year translational study of the oral premalignant lesion (OPL) model has advanced the basic understanding of carcinogenesis. Although retinoids have established activity in this model, a… Expand
Retinoids and their receptors in cancer development and chemoprevention.
Retinoids play an important role in regulating the growth and differentiation of normal, premalignant and malignant cell types, especially epithelial cells, mainly through interaction with two types… Expand
Retinoids in cancer chemoprevention
- R. Lotan
- Medicine
- FASEB journal : official publication of the…
- 1 July 1996
Naturally occurring and synthetic vi‐tamin A metabolites and analogs (retinoids) inhibit tumor development in a variety of cellular, animal, and patient studies. They suppress transformation of cells… Expand
Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin.
BACKGROUND
Retinoids are effective in the treatment and prevention of certain human cancers. Most of their actions are thought to result from changes in gene expression mediated by nuclear retinoic… Expand
Apoptosis as a novel target for cancer chemoprevention.
Cancer chemopreventive agents are typically natural products or their synthetic analogs that inhibit the transformation of normal cells to premalignant cells or the progression of premalignant cells… Expand