• Publications
  • Influence
Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck.
BACKGROUND Patients with head-and-neck cancers who are free of disease after local therapy remain at high risk for both recurrent and second primary tumors. Retinoids have proved efficacious in theExpand
  • 1,316
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International Union of Pharmacology. LX. Retinoic Acid Receptors
Retinoid is a term for compounds that bind to and activate retinoic acid receptors (RARα, RARβ, and RARγ), members of the nuclear hormone receptor superfamily. The most important endogenous retinoidExpand
  • 349
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International Union of Pharmacology. LXIII. Retinoid X Receptors
The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which areExpand
  • 433
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Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles.
Recent developments in photonic technology provide the ability to noninvasively image cells in vivo; these new cellular imaging technologies have the potential to dramatically improve the prevention,Expand
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Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells.
  • R. Lotan
  • Medicine
  • Biochimica et biophysica acta
  • 12 March 1980
  • 1,083
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Predicting cancer development in oral leukoplakia: ten years of translational research.
Our 10-year translational study of the oral premalignant lesion (OPL) model has advanced the basic understanding of carcinogenesis. Although retinoids have established activity in this model, aExpand
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Retinoids and their receptors in cancer development and chemoprevention.
Retinoids play an important role in regulating the growth and differentiation of normal, premalignant and malignant cell types, especially epithelial cells, mainly through interaction with two typesExpand
  • 307
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Retinoids in cancer chemoprevention
  • R. Lotan
  • Medicine
  • FASEB journal : official publication of the…
  • 1 July 1996
Naturally occurring and synthetic vi‐tamin A metabolites and analogs (retinoids) inhibit tumor development in a variety of cellular, animal, and patient studies. They suppress transformation of cellsExpand
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Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin.
BACKGROUND Retinoids are effective in the treatment and prevention of certain human cancers. Most of their actions are thought to result from changes in gene expression mediated by nuclear retinoicExpand
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Apoptosis as a novel target for cancer chemoprevention.
Cancer chemopreventive agents are typically natural products or their synthetic analogs that inhibit the transformation of normal cells to premalignant cells or the progression of premalignant cellsExpand
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