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Prevention of second primary tumors with isotretinoin in squamous-cell carcinoma of the head and neck.
- W. Hong, S. Lippman, L. Peters
- MedicineThe New England journal of medicine
- 20 September 1990
Daily treatment with high doses of isotretinoin is effective in preventing second primary tumors in patients who have been treated for squamous-cell carcinoma of the head and neck, although it does not prevent recurrences of the original tumor.
The purification, composition, and specificity of the anti-T lectin from peanut (Arachis hypogaea).
- R. Lotan, E. Skutelsky, D. Danon, N. Sharon
- Biology, ChemistryThe Journal of biological chemistry
- 10 November 1975
Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells.
- R. Lotan
- MedicineBiochimica et biophysica acta
- 12 March 1980
Galectins: A family of animal β-galactoside-binding lectins
- S. Barondes, V. Castronovo, John L. Wang
- ChemistryCell
- 25 February 1994
International Union of Pharmacology. LXIII. Retinoid X Receptors
- P. Germain, P. Chambon, H. Gronemeyer
- BiologyPharmacological Reviews
- 1 December 2006
This review is focused on the structure, mode of action, ligands, expression, and pharmacology of RXRs, which have been the subject of intense scrutiny since their initial discovery.
International Union of Pharmacology. LX. Retinoic Acid Receptors
- P. Germain, P. Chambon, H. Gronemeyer
- Biology, MedicinePharmacological Reviews
- 1 December 2006
This review summarizes the considerable amount of knowledge generated on retinoids, members of the nuclear hormone receptor superfamily, which regulate a wide variety of essential biological processes, such as vertebrate embryonic morphogenesis and organogenesis, cell growth arrest, differentiation and apoptosis, and homeostasis, as well as their disorders.
Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer.
- F. Khuri, H. Wu, X. Xu
- Medicine, BiologyClinical cancer research : an official journal of…
- 1 April 2001
COX-2 overexpression appears to portend a shorter survival among patients with early stage non-small cell lung cancer, like RAR-beta positivity, which indicates a poor prognosis.
Retinoids in cancer chemoprevention
- R. Lotan
- Medicine, BiologyFASEB journal : official publication of the…
- 1 July 1996
Retinoids are potentially useful agent for cancer chemoprevention and appear to be associated with the ability of retinoids to modulate the growth, differentiation, and apoptosis of normal, premalignant, and malignant cells in vitro and in vivo.
Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles.
- K. Sokolov, M. Follen, R. Richards-Kortum
- BiologyCancer research
- 1 May 2003
A new class of molecular specific contrast agents for vital reflectance imaging based on gold nanoparticles attached to probe molecules with high affinity for specific cellular biomarkers is described and it is shown that gold conjugates can be delivered topically for imaging throughout the whole epithelium.
Predicting cancer development in oral leukoplakia: ten years of translational research.
- J. Lee, W. Hong, S. Lippman
- Medicine, BiologyClinical cancer research : an official journal of…
- 1 May 2000
The most predictive factors of cancer risk are OPL histology, cancer history, and three of the five biomarkers the authors assessed (chromosomal polysomy, p53 protein expression, and loss of heterozygosity at chromosome 3p or 9p) are the strongest predictors for cancer development.
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