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The fluid mosaic model of the structure of cell membranes.
TLDR
A fluid mosaic model is presented for the gross organization and structure of the proteins and lipids of biological membranes. Expand
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The Fluid Mosaic Model of the Structure of Cell Membranes
A fluid mosaic model is presented for the gross organization and structure of the proteins and lipids of biological membranes. The model is consistent with the restrictions imposed by thermodynamics.Expand
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Ultrastructural localization of lectin-binding sites on the zonae pellucidae and plasma membranes of mammalian eggs
Receptors for Ricinus communis agglutinin I (RCAI), concanavalin A (Con A), and wheat germ agglutinin (WGA) were localized on the zonae pellucidae and plasma membranes of hamster, mouse, and rat eggsExpand
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Cancer metastasis. Organ colonization and the cell-surface properties of malignant cells.
  • G. Nicolson
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 21 December 1982
  • 555
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Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression.
  • G. Nicolson
  • Biology, Medicine
  • Cancer research
  • 15 March 1987
It is proposed that tumor cell instability and the expression of cellular diversification mechanisms ensure that malignant neoplasms contain heterogeneous, phenotypically diverse tumor cellExpand
  • 522
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Interactions of tumor cells with vascular endothelial cell monolayers: a model for metastatic invasion.
  • R. Kramer, G. Nicolson
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 November 1979
The interactions of tumorigenic and nontumorigenic human and rodent cells with vascular endothelial cells and their underlying extracellular matrix were studied in culture. The abilities of variousExpand
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Differential expression of membrane-type matrix metalloproteinase and its correlation with gelatinase A activation in human malignant brain tumors in vivo and in vitro.
In this study, we investigated the expression of activated gelatinase A and membrane-type metalloproteinase (MT-MMP) induced by concanavalin A (ConA) in four highly invasive glioma cell lines (UWR2,Expand
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Cancer metastasis: tumor cell and host organ properties important in metastasis to specific secondary sites.
  • G. Nicolson
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 15 November 1988
Cl in ica l and exper imen ta l cons ide ra t ions of organ-speci f ic metas tas i s . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 176 A. G r o w t h rate and metas ta t i cExpand
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Heparanases and tumor metastasis
The successful penetration of endothelial basement membranes is an important process in the formation of hematogenous tumor metastases. Heparan sulfate (HS) proteoglycan is a major constituent ofExpand
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The Fluid-Mosaic Model of Membrane Structure: still relevant to understanding the structure, function and dynamics of biological membranes after more than 40 years.
  • G. Nicolson
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 1 June 2014
In 1972 the Fluid-Mosaic Membrane Model of membrane structure was proposed based on thermodynamic principals of organization of membrane lipids and proteins and available evidence of asymmetry andExpand
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