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Fatty Acid Synthesis Inhibitors

Compounds that interfere with FATTY ACID SYNTHASE resulting in a reduction of FATTY ACIDS. This is a target mechanism in humans of some… Expand
National Institutes of Health

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Related topics

8 relations

Narrower (4)

CeruleninEthionamideTriclosanisoniazid
In Bloodaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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Review
2017
Review
2017
Bacterial fatty acid metabolism in modern antibiotic discovery.
Bacterial fatty acid synthesis is essential for many pathogens and different from the mammalian counterpart. These features make… Expand
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2014
2014
A new pathway of exogenous fatty acid incorporation proceeds by a classical phosphoryl transfer reaction.
The Firmicute bacteria readily incorporate exogenous fatty acids into their phospholipids. In some (but not all) family members… Expand
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2013
2013
Staphylococcus aureus fatty acid auxotrophs do not proliferate in mice.
Inactivation of acetyl-coenzyme A (acetyl-CoA) carboxylase confers resistance to fatty acid synthesis inhibitors in… Expand
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Highly Cited
2012
Highly Cited
2012
SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids
Increased metabolism is a requirement for tumor cell proliferation. To understand the dependence of tumor cells on fatty acid… Expand
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2012
2012
Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds.
Reducing lipid accumulation in insulin target tissues is critical for the treatment of type 2 diabetes. This study aimed to… Expand
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2007
2007
The method of treatment with fatty acid synthesis inhibitors
The present invention has a fatty acid synthesis inhibitor activity, as well as obesity, cancer, diabetes, fungal infections… Expand
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2005
2005
Determination of selectivity and efficacy of fatty acid synthesis inhibitors.
Type II fatty acid synthesis (FASII) is essential to bacterial cell viability and is a promising target for the development of… Expand
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