FAQ

Fatty Acid Synthesis Inhibitors

Compounds that interfere with FATTY ACID SYNTHASE resulting in a reduction of FATTY ACIDS. This is a target mechanism in humans of some… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2005-2017
0120052017

Related topics

Related topics

8 relations

Narrower (4)

CeruleninEthionamideTriclosanisoniazid
In Bloodchemical synthesisisolation & purification analysisstandards characteristics

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Fatty Acid Synthesis Inhibitors
isoniazid
In Blood
chemical synthesis
Triclosan
Ethionamide

Papers overview

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Review
2017
Review
2017
Bacterial fatty acid metabolism in modern antibiotic discovery.
Bacterial fatty acid synthesis is essential for many pathogens and different from the mammalian counterpart. These features make… (More)
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2015
2015
A thioesterase bypasses the requirement for exogenous fatty acids in the plsX deletion of Streptococcus pneumoniae.
PlsX is an acyl-acyl carrier protein (ACP):phosphate transacylase that interconverts the two acyl donors in Gram-positive… (More)
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2014
2014
A new pathway of exogenous fatty acid incorporation proceeds by a classical phosphoryl transfer reaction.
The Firmicute bacteria readily incorporate exogenous fatty acids into their phospholipids. In some (but not all) family members… (More)
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2014
2014
Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening.
The elongation condensing enzymes in the bacterial fatty acid biosynthesis pathway represent desirable targets for the design of… (More)
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2013
2013
Staphylococcus aureus fatty acid auxotrophs do not proliferate in mice.
Inactivation of acetyl-coenzyme A (acetyl-CoA) carboxylase confers resistance to fatty acid synthesis inhibitors in… (More)
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2012
2012
SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids
Increased metabolism is a requirement for tumor cell proliferation. To understand the dependence of tumor cells on fatty acid… (More)
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2012
2012
Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds.
Reducing lipid accumulation in insulin target tissues is critical for the treatment of type 2 diabetes. This study aimed to… (More)
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2011
2011
Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors.
The rationale for the pursuit of bacterial type 2 fatty acid synthesis (FASII) as a target for antibacterial drug discovery in… (More)
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2005
2005
Determination of selectivity and efficacy of fatty acid synthesis inhibitors.
Type II fatty acid synthesis (FASII) is essential to bacterial cell viability and is a promising target for the development of… (More)
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