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Fatty Acid Synthesis Inhibitors

Compounds that interfere with FATTY ACID SYNTHASE resulting in a reduction of FATTY ACIDS. This is a target mechanism in humans of some… 
National Institutes of Health

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CeruleninEthionamideTriclosanisoniazid
In Bloodaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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Review
2017
Review
2017
Bacterial fatty acid metabolism in modern antibiotic discovery.
  • Jiangwei Yao, C. Rock
  • Biochimica et biophysica acta. Molecular and cell…
  • 2017
  • Corpus ID: 205828384
2014
2014
A new pathway of exogenous fatty acid incorporation proceeds by a classical phosphoryl transfer reaction
  • J. Cronan
  • Molecular microbiology
  • 2014
  • Corpus ID: 5950995
The Firmicute bacteria readily incorporate exogenous fatty acids into their phospholipids. In some (but not all) family members… 
2013
2013
Staphylococcus aureus Fatty Acid Auxotrophs Do Not Proliferate in Mice
ABSTRACT Inactivation of acetyl-coenzyme A (acetyl-CoA) carboxylase confers resistance to fatty acid synthesis inhibitors in… 
Highly Cited
2012
Highly Cited
2012
SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids
Increased metabolism is a requirement for tumor cell proliferation. To understand the dependence of tumor cells on fatty acid… 
2012
2012
Screening for the efficacy on lipid accumulation in 3T3-L1 cells is an effective tool for the identification of new anti-diabetic compounds.
2007
2007
The method of treatment with fatty acid synthesis inhibitors
The present invention has a fatty acid synthesis inhibitor activity, as well as obesity, cancer, diabetes, fungal infections… 
Highly Cited
2005
Highly Cited
2005
Determination of Selectivity and Efficacy of Fatty Acid Synthesis Inhibitors*
Type II fatty acid synthesis (FASII) is essential to bacterial cell viability and is a promising target for the development of… 
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