Fatty Acid Synthesis Inhibitors

Compounds that interfere with FATTY ACID SYNTHASE resulting in a reduction of FATTY ACIDS. This is a target mechanism in humans of some… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2005-2017
0120052017

Papers overview

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Review
2017
Review
2017
Bacterial fatty acid synthesis is essential for many pathogens and different from the mammalian counterpart. These features make… (More)
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2015
2015
PlsX is an acyl-acyl carrier protein (ACP):phosphate transacylase that interconverts the two acyl donors in Gram-positive… (More)
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2014
2014
The Firmicute bacteria readily incorporate exogenous fatty acids into their phospholipids. In some (but not all) family members… (More)
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2014
2014
The elongation condensing enzymes in the bacterial fatty acid biosynthesis pathway represent desirable targets for the design of… (More)
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2013
2013
Inactivation of acetyl-coenzyme A (acetyl-CoA) carboxylase confers resistance to fatty acid synthesis inhibitors in… (More)
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2012
2012
Increased metabolism is a requirement for tumor cell proliferation. To understand the dependence of tumor cells on fatty acid… (More)
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2012
2012
Reducing lipid accumulation in insulin target tissues is critical for the treatment of type 2 diabetes. This study aimed to… (More)
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2011
2011
The rationale for the pursuit of bacterial type 2 fatty acid synthesis (FASII) as a target for antibacterial drug discovery in… (More)
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2005
2005
Type II fatty acid synthesis (FASII) is essential to bacterial cell viability and is a promising target for the development of… (More)
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