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Fatty Acid Synthesis Inhibitors

Compounds that interfere with FATTY ACID SYNTHASE resulting in a reduction of FATTY ACIDS. This is a target mechanism in humans of some… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
  • Jiangwei Yao, C. Rock
  • Biochimica et biophysica acta. Molecular and cell…
  • 2017
  • Corpus ID: 205828384
Bacterial fatty acid synthesis is essential for many pathogens and different from the mammalian counterpart. These features make… Expand
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2014
2014
  • J. Cronan
  • Molecular microbiology
  • 2014
  • Corpus ID: 5950995
The Firmicute bacteria readily incorporate exogenous fatty acids into their phospholipids. In some (but not all) family members… Expand
2013
2013
ABSTRACT Inactivation of acetyl-coenzyme A (acetyl-CoA) carboxylase confers resistance to fatty acid synthesis inhibitors in… Expand
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Highly Cited
2012
Highly Cited
2012
Increased metabolism is a requirement for tumor cell proliferation. To understand the dependence of tumor cells on fatty acid… Expand
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2012
2012
Reducing lipid accumulation in insulin target tissues is critical for the treatment of type 2 diabetes. This study aimed to… Expand
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2007
2007
The present invention has a fatty acid synthesis inhibitor activity, as well as obesity, cancer, diabetes, fungal infections… Expand
Highly Cited
2005
Highly Cited
2005
Type II fatty acid synthesis (FASII) is essential to bacterial cell viability and is a promising target for the development of… Expand
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