Cerulenin

Known as: (2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)-oxirane-2-carboxylic acid amide, Cerulenin [Chemical/Ingredient], (2R,3S)-3-((4e,7e)-Nona-4,7-dienoyl)oxirane-2-carboxamide 
An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several… (More)
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Fatty acid synthase (FASN) is a key enzyme involved in neoplastic lipogenesis. Overexpression of FASN is common in many cancers… (More)
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Review
2006
Review
2006
The expression and activity of Fatty Acid Synthase (FASN; the sole enzyme capable of the reductive de novo synthesis of long… (More)
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2002
2002
Cerulenin, a fungal metabolite, is known to be a specific inhibitor of fatty acid synthase. Here we report that cerulenin is an… (More)
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2001
2001
Cerulenin is a fungal mycotoxin that potently inhibits fatty acid synthesis by covalent modification of the active site thiol of… (More)
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Highly Cited
2000
Highly Cited
2000
Compared to normal human tissues, many common human cancers, including carcinoma of the colon, prostate, ovary, breast, and… (More)
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1999
1999
Activation of ras oncogenes occurs in a high percentage of tumors, making the enzymes involved in the posttranslational… (More)
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Highly Cited
1998
Highly Cited
1998
Pharmacological inhibitors of the anabolic enzyme, fatty acid synthase (FAS), including the natural product cerulenin and the… (More)
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Highly Cited
1996
Highly Cited
1996
Some Candida albicans isolates from AIDS patients with oropharyngeal candidiasis are becoming resistant to the azole antifungal… (More)
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Highly Cited
1994
Highly Cited
1994
OA-519 is a prognostic molecule found in tumor cells from breast cancer patients with markedly worsened prognosis. We purified OA… (More)
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1989
1989
A cerulenin insensitive 3-ketoacyl-acyl carrier protein synthase has been assayed in extracts of spinach (Spinacia oleracea) leaf… (More)
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