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Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study.
TLDR
The selective down-regulation of RELN and GAD(67) in prefrontal cortex of patients with schizophrenia and bipolar disorder who have psychosis is consistent with the hypothesis that these parameters are vulnerability factors in psychosis; this plus the loss of the correlation between these 2 parameters that exists in nonpsychotic subjects support the hypotheses that these changes may be liability factors underlying psychosis. Expand
Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine.
TLDR
The normalization of CSF ALLO content in depressed patients appears to be sufficient to mediate the anxiolytic and antidysphoric actions of fluoxetine or fluvoxamine via its positive allosteric modulation of GABA type A receptors. Expand
A decrease of reelin expression as a putative vulnerability factor in schizophrenia.
TLDR
In all of the brain areas studied, RELN and its mRNA were significantly reduced in patients with schizophrenia; this decrease was similar in patients affected by undifferentiated or paranoid schizophrenia and is interpreted within a neurodevelopmental/vulnerability "two-hit" model for the etiology of schizophrenia. Expand
Reelin is preferentially expressed in neurons synthesizing gamma-aminobutyric acid in cortex and hippocampus of adult rats.
TLDR
In adult rat cerebellum, Reelin is expressed in glutamatergic neurons (granule cells), and the translated product of this mRNA is readily exported from the granule cell somata to the parallel fibers, where it has been detected by electron microscopy in axon terminals located presynaptically to Purkinje cell dendrites. Expand
Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis
TLDR
It is demonstrated that 5α-R type I and 3α-HSD colocalize in cortical, hippocampal, and olfactory bulb glutamatergic principal neurons and in some output neurons of the amygdala and thalamus, and data suggest that ALLO and THDOC modulate GABA action at GABAA receptors, either with an autocrine or a paracrine mechanism or by reaching GabAA receptor intracellular sites through lateral membrane diffusion. Expand
Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.
TLDR
The results begin to illuminate the novel contributions of the delta subunit to GABA pharmacology and sedative/hypnotic responses and behavior and provide insights into the physiology of neurosteroids. Expand
Glutamic acid decarboxylase and glutamate receptor changes during tolerance and dependence to benzodiazepines
TLDR
The results suggest an involvement of GABA-mediated processes in the development and maintenance of tolerance to diazepam, whereas excitatory amino acid-related processes (presumably via AMPA receptors) may be involved in the expression of signs of dependence after withdrawal. Expand
Diazepam binding inhibitor (DBI): a peptide with multiple biological actions.
TLDR
Accumulating evidence suggests that the various neurobiological actions of DBI and its processing products may be attributable to the ability of these peptides either to bind to BZD recognition sites associated with GABAA receptors or to binds to glial cell MBRs and modulate the rate and quality of neurosteroidogenesis. Expand
The phenotypic characteristics of heterozygous reeler mouse.
TLDR
Histological and behavioral traits are associated with reelin (Reln) haplo-insufficiency in heterozygous reeler mouse (rl+/-) and signs of psychosis vulnerability are discussed. Expand
Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors.
TLDR
DBI injected intraventricularly at doses of 5-10 nmol completely reversed the anticonflict action of diazepam on unpunished drinking and facilitated the shock-induced suppression of drinking by lowering the threshold for this response. Expand
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