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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
This study uses a chemical genetic screen to identify a small molecule, XAV939, which selectively inhibits β-catenin-mediated transcription and reveals new mechanistic insights into the regulation of axin protein homeostasis, which presents new avenues for targeted Wnt pathway therapies.
A major developmental transition in early xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage
Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryos
Dynamic instability of microtubule growth
We report here that microtubules in vitro coexist in growing and shrinking populations which interconvert rather infrequently. This dynamic instability is a general property of microtubules and may…
Cyclin is degraded by the ubiquitin pathway
Cyclin degradation is the key step governing exit from mitosis and progress into the next cell cycle, and anaphase may be triggered by the recognition of cyclin by the ubiquitin-conjugating system.
A major developmental transition in early xenopus embryos: II. control of the onset of transcription
Geminin, an Inhibitor of DNA Replication, Is Degraded during Mitosis
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck
It is proposed that Rac1 and Nck cause dissociation of the WAVE1 complex, which releases activeWAVE1–HSPC300 and leads to actin nucleation.