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Cortical motor reorganization in akinetic patients with Parkinson's disease: a functional MRI study.
Using functional MRI (fMRI), we have studied the changes induced by the performance of a complex sequential motor task in the cortical areas of six akinetic patients with Parkinson's disease and sixExpand
Effect of levodopa on pain threshold in Parkinson's disease: A clinical and positron emission tomography study
It is shown that pain threshold is lower in Parkinson's disease patients but returns to normal ranges after levodopa administration, and PD patients have higher pain‐induced activation in nociceptive pathways, which can be reduced bylevodopa. Expand
The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients.
The results suggest that parkinsonian patients off medication may try to compensate for their basal ganglia-cortical loop's dysfunction using other motor pathways involving cerebellar relays. Expand
Supplementary and primary sensory motor area activity in Parkinson's disease. Regional cerebral blood flow changes during finger movements and effects of apomorphine.
The hypothesis that a functional cortical motor area deafferentation is involved in the pathophysiological makeup of akinesia and that this abnormality is reversed by dopaminergic drugs is supported. Expand
Limitations of current Parkinson's disease therapy
The current antiparkinsonian therapy cannot be considered as ideal with regard to both efficacy and safety. Expand
Benfluorex and valvular heart disease: a cohort study of a million people with diabetes mellitus
To evaluate and quantify in diabetic patients treated with benfluorex in France, a fenfluramine‐derivated product, a possible increase in risk of valvular heart disease, previously suggested byExpand
Prevalence of orthostatic hypotension in Parkinson’s disease
The frequency of orthostatic hypotension in Parkinson’s disease is high and it is possible to establish a clinical rating scale which could be used to assess the effects of drugs employed in the management of orthofiltration. Expand
Square wave jerks in parkinsonian syndromes.
Square wave jerks are probably not related to the central degeneration of the dopaminergic nigrostriatal pathway observed in PD and may help to differentiate PD clinically from other Parkinsonian syndromes. Expand
Cortical motor overactivation in parkinsonian patients with L-dopa-induced peak-dose dyskinesia.
The results are compatible with the hypothesis that an hyperkinetic abnormal involuntary movement, like L-dopa-induced peak dose dyskinesia, is due to a disinhibition of the primary and associated motor cortex secondary to an excessive outflow of the pallidothalamocortical motor loop. Expand
Potentially inappropriate medication use among patients with Alzheimer disease in the REAL.FR cohort: be aware of atropinic and benzodiazepine drugs!
The results reveal that approximately one out of two community-dwelling patients with mild-to-moderate AD treated by AD specialists use PIMs, and indicate that the characteristics of the disease and the pharmacodynamic/pharmacokinetic profile of the drugs prescribed are not sufficiently taken into account by physicians when prescribing for AD patients. Expand