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gemcitabine

Known as: 2'-Deoxy-2',2'-difluorocytidine, dFdC, 2',2'-DFDC 
A broad-spectrum antimetabolite and deoxycytidine analogue with antineoplastic activity. Upon administration, gemcitabine is converted into the… 
National Institutes of Health

Related topics

Related topics

22 relations

Broader (8)

AntimetabolitesAntimetabolites, AntineoplasticAntineoplastic AgentsAntiviral Agents
Carcinoma, Pancreatic DuctalDNA Synthesis InhibitionDrug AllergyGemcitabine hydrochloride

Narrower (2)

GemzarLY 188011

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial.
Highly Cited
2008
Highly Cited
2008
Phase III trial of gemcitabine compared with pegylated liposomal doxorubicin in progressive or recurrent ovarian cancer.
PURPOSE We aimed at investigating the efficacy, tolerability, and quality of life (QOL) of gemcitabine (GEM) compared with… 
Highly Cited
2006
Highly Cited
2006
Hubble Space Telescope Fine Guidance Sensor Parallaxes of Galactic Cepheid Variable Stars: Period-Luminosity Relations
We present new absolute trigonometric parallaxes and relative proper motions for nine Galactic Cepheid variable stars: ℓ Car… 
Highly Cited
2004
Highly Cited
2004
Gemcitabine‐associated thrombotic microangiopathy
Gemcitabine‐associated thrombotic microangiopathy (TMA) is believed to be very rare, with an estimated incidence rate of 0.015… 
Highly Cited
2004
Highly Cited
2004
Hypoxia Increases Resistance of Human Pancreatic Cancer Cells to Apoptosis Induced by Gemcitabine
Purpose: Hypoxia, frequently found in the center of solid tumor, is associated with resistance to chemotherapy by activation of… 
Highly Cited
2001
Highly Cited
2001
Platinum-based and non-platinum-based chemotherapy in advanced non-small-cell lung cancer: a randomised multicentre trial
Highly Cited
2000
Highly Cited
2000
Gemcitabine plus vinorelbine versus vinorelbine alone in elderly patients with advanced non-small-cell lung cancer.
PURPOSE To evaluate whether the addition of gemcitabine (G) to vinorelbine (V) improves survival and quality of life (QoL) among… 
Highly Cited
2000
Highly Cited
2000
Phase II trial of gemcitabine plus cisplatin in patients with metastatic urothelial cancer.
PURPOSE To assess the activity and toxicity of the combination of gemcitabine and cisplatin in the treatment of chemotherapy… 
Highly Cited
2000
Highly Cited
2000
Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase.
The blockade of epidermal growth factor receptor (EGFR) function with monoclonal antibodies has major antiproliferative effects… 
Highly Cited
1996
Highly Cited
1996
Radiosensitization of pancreatic cancer cells by 2',2'-difluoro-2'-deoxycytidine.
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