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gemcitabine

Known as: 2'-Deoxy-2',2'-difluorocytidine, dFdC, 2',2'-DFDC 
A broad-spectrum antimetabolite and deoxycytidine analogue with antineoplastic activity. Upon administration, gemcitabine is converted into the… 
National Institutes of Health

Related topics

Related topics

22 relations

Broader (8)

AntimetabolitesAntimetabolites, AntineoplasticAntineoplastic AgentsAntiviral Agents
Carcinoma, Pancreatic DuctalDNA Synthesis InhibitionDrug AllergyGemcitabine hydrochloride

Narrower (2)

GemzarLY 188011

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Silver-catalyzed oxidative decarboxylation of difluoroacetates: efficient access to C-CF2 bond formation.
A mild, versatile and efficient method for the silver(I)-catalyzed oxidative decarboxylative gem-difluoromethylenation has been… 
Highly Cited
2015
Highly Cited
2015
Selective efficacy of zoledronic acid on metastasis in a patient‐derived orthotopic xenograph (PDOX) nude‐mouse model of human pancreatic cancer
Patient‐derived orthotopic xenograft (PDOX) nude‐mouse models replicate the behavior of clinical cancer, including metastasis… 
Review
2003
Review
2003
gem-Diamine 1-N-iminosugars and related iminosugars, candidate of therapeutic agents for tumor metastasis.
Cancer metastasis is one of the major challenges in cancer research. Inhibitors of tumor metastasis are rapidly emerging as… 
Highly Cited
2002
Highly Cited
2002
Sealed GEM photomultiplier with a CsI photocathode: ion feedback and ageing
Highly Cited
2001
Highly Cited
2001
Critical Analysis of Dual-Chamber Implantable Cardioverter-Defibrillator Arrhythmia Detection: Results and Technical Considerations
Highly Cited
1996
Highly Cited
1996
Calmodulin Binds to and Inhibits GTP Binding of the Ras-like GTPase Kir/Gem*
Recently, a new subfamily of Ras-related GTP-binding proteins consisting of Rad (as ssociated with iabetes), Gem (immediate early… 
Highly Cited
1996
Highly Cited
1996
Desulfurative fluorination using nitrosonium tetrafluoroborate and pyridinium poly(hydrogen fluoride)
Review
1980
Review
1980
The effects of cattle pasture on soil fertility in the Brazilian Amazon: consequences for beef production sustainability.
Amazon rainforest is fast being replaced by cattle pastures as investors respond to financial incentives and the lure of new… 
Highly Cited
1977
Highly Cited
1977
Pyrophosphate inhibition of carbon dioxide fixation in isolated pea chloroplasts by uptake in exchange for endogenous adenine nucleotides.
Carbon dioxide-dependent O(2) evolution by isolated pea (Pisum sativum) chloroplasts was inhibited by inorganic pyrophosphate… 
Highly Cited
1977
Highly Cited
1977
Inhibition and alternate-substrate studies on the mechanism of malic enzyme.
A number of dead-end inhibitors and alternate substrates were examined to gain an understanding of the substrate specificity and… 
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