Y. Nishimura

Publications212
h-index24
Citations2,360
Highly Influential Citations14
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Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex.
TLDR
There is isoform specificity in the interaction between P450s and UGTs, suggesting that UGT in the complex with P 450s is functionally active.
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INHIBITION OF UDP-GLUCURONOSYLTRANSFERASE 2B7-CATALYZED MORPHINE GLUCURONIDATION BY KETOCONAZOLE: DUAL MECHANISMS INVOLVING A NOVEL NONCOMPETITIVE MODE
TLDR
Results suggest that 1) metabolism of ketoconazole by P450 is not required for inhibition of UGT2B7-catalyzed morphine glucuronidation; and 2) this drug exerts its inhibitory effect on morphine UGT by novel mechanisms involving competitive and noncompetitive inhibition.
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Flexible synthesis and biological activity of uronic acid-type gem-diamine 1-N-iminosugars: a new family of glycosidase inhibitors.
TLDR
An efficient and flexible synthetic route to four gem-diamine 1-N-iminosugars of uronic acid-type and a new family of glycosidase inhibitor, from l-galactono-1,4-lactone are developed in an enantiodivergent fashion.
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Maternal Exposure to Dioxin Disrupts Gonadotropin Production in Fetal Rats and Imprints Defects in Sexual Behavior
TLDR
It is demonstrated that TCDD disrupts steroidogenesis in fetuses by targeting pituitary gonadotropin production and imprints demasculinization in males and defeminization in females in terms of their copulatory behavior.
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Synthesis of 3'-deoxykanamycin effective against kanamycin-resistant Escherichia coli and Pseudomonas aeruginosa.
TLDR
The authors attempted, for the first approach, to prepare 3r-0-methylkanamycin (I) by a synthetic method, and suggested that blocking or removal of the hydroxyl group which is phosphorylated will give new compounds effective against the resistant organisms.
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Tripropeptin C Blocks the Lipid Cycle of Cell Wall Biosynthesis by Complex Formation with Undecaprenyl Pyrophosphate
TLDR
TPPC can potentially inhibit C55-PP phosphatase activity, which plays a crucial role in the lipid cycle of peptidoglycan synthesis, and this mode of action is different from that of currently available drugs such as vancomycin, daptomycin, and bacitracin.
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All eight stereoisomeric D-glyconic-delta-lactams: synthesis, conformational analysis, and evaluation as glycosidase inhibitors.
TLDR
An efficient and general synthetic route to all eight stereoisomeric D-glycono-delta-lactams has been developed andalyses of conformation and glycosidase-inhibition provide useful information for the design of new glycosIDase inhibitors.
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Alteration of the Function of the UDP-Glucuronosyltransferase 1A Subfamily by Cytochrome P450 3A4: Different Susceptibility for UGT Isoforms and UGT1A1/7 Variants
TLDR
CYP3A4 changes the catalytic function of the UGT1A subfamily in a UGT isoform-specific manner and nonsynonymous mutations in UGT 1A7*3 reduce not only the ability of UGT to use UDP-GlcUA but also CYP 3A4-mediated enhancement of catalytic activity, whereas CYP3A 4 is able to restore the U GT1A1*6 function.
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Cyclic Lipopeptide Antibiotics
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Synthesis of 3-episiastatin B analogues having anti-influenza virus activity.
TLDR
Compound 3 showed marked inhibitory activity against influenza virus neuraminidases and significant inhibition of influenza virus infection in vitro.
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