• Publications
  • Influence
Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.
Despite the high doses of radiation delivered in the treatment of patients with glioblastoma multiforme (GBM), the tumors invariably recur within the irradiation field, resulting in a low cure rate.Expand
  • 606
  • 47
  • Open Access
Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force
The physical limits of cell migration in dense porous environments are dependent upon the available space and the deformability of the nucleus and are modulated by matrix metalloproteinases,Expand
  • 725
  • 44
  • Open Access
Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL–RANK signalling
Inflammatory mechanisms influence tumorigenesis and metastatic progression even in cancers whose aetiology does not involve pre-existing inflammation or infection, such as breast and prostateExpand
  • 451
  • 29
Transdifferentiation of glioblastoma cells into vascular endothelial cells
Glioblastoma (GBM) is the most malignant brain tumor and is highly resistant to intensive combination therapies and anti-VEGF therapies. To assess the resistance mechanism to anti-VEGF therapy, weExpand
  • 375
  • 26
  • Open Access
A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy
p53 and INK4a/ARF mutations promote tumorigenesis and drug resistance, in part, by disabling apoptosis. We show that primary murine lymphomas also respond to chemotherapy by engaging a senescenceExpand
  • 886
  • 24
  • Open Access
Gene expression profiling predicts clinical outcome of prostate cancer.
One of the major problems in management of prostate cancer is the lack of reliable genetic markers predicting the clinical course of the disease. We analyzed expression profiles of 12,625 transcriptsExpand
  • 455
  • 24
  • Open Access
Dissecting p53 tumor suppressor functions in vivo.
Although the p53 tumor suppressor acts in a plethora of processes that influence cellular proliferation and survival, it remains unclear which p53 functions are essential for tumor suppression and,Expand
  • 487
  • 18
  • Open Access
Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling
Hepatocellular carcinoma (HCC) is a slowly developing malignancy postulated to evolve from premalignant lesions in chronically damaged livers. However, it was never established that premalignantExpand
  • 299
  • 16
  • Open Access
Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity.
A heparin binding mitogenic protein isolated from bovine uterus shares NH2-terminal amino acid sequence with a protein isolated from newborn rat brain. The cDNA's of the bovine, human, and rat genesExpand
  • 440
  • 13
Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons.
We have recently shown that the expression of nestin, the neural stem cell marker protein, is expressed in bulge-area stem cells of the hair follicle. We used transgenic mice with GFP expressionExpand
  • 363
  • 12
  • Open Access