Carcinoma, Pancreatic Ductal

Known as: Carcinoma, Pancreatic Ductal [Disease/Finding], Pancreas Duct-Cell Carcinoma, Carcinoma, Ductal, Pancreatic 
Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
National Institutes of Health

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Highly Cited
2015
Highly Cited
2015
Organoid Models of Human and Mouse Ductal Pancreatic Cancer
Pancreatic cancer is one of the most lethal malignancies due to its late diagnosis and limited response to treatment. Tractable… (More)
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Highly Cited
2012
Highly Cited
2012
Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma.
Pancreatic ductal adenocarcinomas (PDAs) are characterized by a robust fibroinflammatory response. We show here that this… (More)
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Highly Cited
2007
Highly Cited
2007
Expression of the "stem cell marker" CD133 in pancreas and pancreatic ductal adenocarcinomas
It has been suggested that a small population of cells with unique self-renewal properties and malignant potential exists in… (More)
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Highly Cited
2006
Highly Cited
2006
Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions.
PURPOSE Antitumor immune response changes drastically during the progression of cancers. Established cancers often escape from… (More)
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Highly Cited
2004
Highly Cited
2004
Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta.
Pancreatic ductal carcinoma is characterized by a profound chemoresistance. As we have shown previously, these tumor cells can… (More)
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Highly Cited
2004
Highly Cited
2004
Gene expression profiling of microdissected pancreatic ductal carcinomas using high-density DNA microarrays.
Pancreatic ductal adenocarcinoma (PDAC) remains an important cause of malignancy-related death and is the eighth most common… (More)
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Highly Cited
2003
Highly Cited
2003
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.
To evaluate the role of oncogenic RAS mutations in pancreatic tumorigenesis, we directed endogenous expression of KRAS(G12D) to… (More)
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Highly Cited
2003
Highly Cited
2003
A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform
There are a large number of stable pancreatic ductal carcinoma cell lines that are used by researchers worldwide. Detailed data… (More)
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Highly Cited
2001
Highly Cited
2001
Genetic profile of 22 pancreatic carcinoma cell lines
The K-ras, p53, p16 and DPC4 genes are among those most frequently altered in pancreatic ductal carcinoma. We analyzed 22 cell… (More)
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Highly Cited
1994
Highly Cited
1994
Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
Pancreatic adenocarcinoma is the fifth leading cause of cancer death in the United States. Mutations in the K-ras oncogene occur… (More)
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