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gabapentin

Known as: gabapentin [Chemical/Ingredient], Gabapentina, Convalis 
A synthetic analogue of the neurotransmitter gamma-aminobutyric acid with anticonvulsant activity. Although its exact mechanism of action is unknown… Expand
National Institutes of Health

Related topics

Related topics

31 relations

Broader (9)

AminesAnalgesicsAnti-Anxiety AgentsAnticonvulsants
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Antidepressive AgentsAntiepileptic AgentsBipolar DisorderCalcium Channel Blockers
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Narrower (3)

GraliseHorizantNeurontin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Gabapentin for chronic neuropathic pain and fibromyalgia in adults.
BACKGROUND This review updates parts of two earlier Cochrane reviews investigating effects of gabapentin in chronic neuropathic… Expand
Highly Cited
2009
Highly Cited
2009
Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis
Synapses are asymmetric cellular adhesions that are critical for nervous system development and function, but the mechanisms that… Expand
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Review
2006
Review
2006
The mechanisms of action of gabapentin and pregabalin.
  • G. Sills
  • Current opinion in pharmacology
  • 2006
    • Corpus ID: 6808531
Gabapentin and pregabalin are structurally related compounds with recognized efficacy in the treatment of both epilepsy and… Expand
Highly Cited
2005
Highly Cited
2005
Morphine, gabapentin, or their combination for neuropathic pain.
BACKGROUND The available drugs to treat neuropathic pain have incomplete efficacy and dose-limiting adverse effects. We compared… Expand
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Review
2002
Review
2002
Gabapentin: pharmacology and its use in pain management
Summary Although its exact mode of action is not known, gabapentin appears to have a unique effect on voltage‐dependent calcium… Expand
Highly Cited
2002
Highly Cited
2002
Inhibition of neuronal Ca2+ influx by gabapentin and pregabalin in the human neocortex
Gabapentin and pregabalin (S-(+)-3-isobutylgaba) produced concentration-dependent inhibitions of the K(+)-induced [Ca(2+)](i… Expand
Highly Cited
1998
Highly Cited
1998
Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial.
CONTEXT Postherpetic neuralgia (PHN) is a syndrome of often intractable neuropathic pain following herpes zoster (shingles) that… Expand
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Highly Cited
1998
Highly Cited
1998
Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial.
CONTEXT Pain is the most disturbing symptom of diabetic peripheral neuropathy. As many as 45% of patients with diabetes mellitus… Expand
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Review
1998
Review
1998
A summary of mechanistic hypotheses of gabapentin pharmacology
Although the cellular mechanisms of pharmacological actions of gabapentin (Neurontin) remain incompletely described, several… Expand
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Highly Cited
1996
Highly Cited
1996
The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the Subunit of a Calcium Channel (*)
Gabapentin (1-(aminomethyl)cyclohexane acetic acid; Neurontin) is a novel anticonvulsant drug, with a mechanism of action… Expand
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