gabapentin

Known as: gabapentin [Chemical/Ingredient], Gabapentina, Convalis 
A synthetic analogue of the neurotransmitter gamma-aminobutyric acid with anticonvulsant activity. Although its exact mechanism of action is unknown… (More)
National Institutes of Health

Related topics

Related topics

31 relations

Broader (9)

AminesAnalgesicsAnti-Anxiety AgentsAnticonvulsants
(More)
Antidepressive AgentsAntiepileptic AgentsBipolar DisorderCalcium Channel Blockers
(More)

Narrower (3)

GraliseHorizantNeurontin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial
BACKGROUND Carbamazepine is widely accepted as a drug of first choice for patients with partial onset seizures. Several newer… (More)
Is this relevant?
Review
2006
Review
2006
The mechanisms of action of gabapentin and pregabalin.
Gabapentin and pregabalin are structurally related compounds with recognized efficacy in the treatment of both epilepsy and… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Analgesic effects of gabapentin after spinal surgery.
BACKGROUND A combination of opioid and nonopioid analgesic drugs may improve the quality of postoperative analgesia as well as… (More)
  • table 1
  • table 2
  • table 4
  • table 3
Is this relevant?
Review
2002
Review
2002
Gabapentin: pharmacology and its use in pain management.
Although its exact mode of action is not known, gabapentin appears to have a unique effect on voltage-dependent calcium ion… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Inhibition of neuronal Ca(2+) influx by gabapentin and pregabalin in the human neocortex.
Gabapentin and pregabalin (S-(+)-3-isobutylgaba) produced concentration-dependent inhibitions of the K(+)-induced [Ca(2+)](i… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
A randomized study of the effects of single-dose gabapentin versus placebo on postoperative pain and morphine consumption after mastectomy.
BACKGROUND The anticonvulsant gabapentin has proven effective for neuropathic pain in three large placebo-controlled clinical… (More)
  • figure 1
  • figure 2
  • table 1
  • table 2
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Efficacy of gabapentin in migraine prophylaxis.
OBJECTIVE To compare gabapentin with placebo for use as a prophylactic agent in patients with migraine (with or without aura… (More)
  • figure 1
  • figure 2
  • table 1
  • table 2
  • table 3
Is this relevant?
Review
1998
Review
1998
A summary of mechanistic hypotheses of gabapentin pharmacology
Although the cellular mechanisms of pharmacological actions of gabapentin (Neurontin) remain incompletely described, several… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1996
Highly Cited
1996
The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel.
Gabapentin (1-(aminomethyl)cyclohexane acetic acid; Neurontin) is a novel anticonvulsant drug, with a mechanism of action… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Gabapentin adjunctive therapy in neuropathic pain states.
OBJECTIVE This is a report of a trial of the new antiepileptic agent gabapentin in patients with intractable neuropathic pain… (More)
Is this relevant?