D. Canafax

Publications169
h-index28
Citations3,069
Highly Influential Citations56
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • D. Sutherland
  • 1,215 Publications • 38,796 Citations
  • B. Kahan
  • 974 Publications • 27,465 Citations
  • R. Simmons
  • 1,091 Publications • 46,882 Citations
  • J. Najarian
  • 1,060 Publications • 29,435 Citations
  • Publications
  • Influence
Randomized, double-blind, placebo-controlled study of XP13512/GSK1838262 in patients with RLS
TLDR
XP13512 1,200 mg, taken once daily, significantly improved restless legs syndrome (RLS) symptoms compared with placebo and was generally well tolerated in adults with moderate to severe primary RLS.
Clinical efficacy of antimicrobial drugs for acute otitis media: metaanalysis of 5400 children from thirty-three randomized trials.
Clinical Pharmacokinetics of XP13512, a Novel Transported Prodrug of Gabapentin
TLDR
XP13512 may provide more predictable gabapentin exposure and decreased dosing frequency because it is a novel transported prodrug of gABapentin that is absorbed throughout the entire length of the intestine by high‐capacity nutrient transporters.
Amoxicillin middle ear fluid penetration and pharmacokinetics in children with acute otitis media.
TLDR
MEF amoxicillin penetration tended to be lower in children with viral infection, which is inadequate to effectively eradicate resistant Streptococcus pneumoniae, particularly during viral coinfection.
Results of the Minnesota randomized prospective trial of cyclosporine versus azathioprine-antilymphocyte globulin for immunosuppression in renal allograft recipients.
Efficacy of gabapentin enacarbil vs placebo in patients with postherpetic neuralgia and a pharmacokinetic comparison with oral gabapentin.
TLDR
GEn was effective in providing PHN pain relief, improved gabapentin exposure compared with gabAPentin capsules, and was generally safe and well tolerated in patients with PHN.
Sensitive assay for measuring amoxicillin in human plasma and middle ear fluid using solid-phase extraction and reversed-phase high-performance liquid chromatography.
Validation of the post sleep questionnaire for assessing subjects with restless legs syndrome: results from two double-blind, multicenter, placebo-controlled clinical trials
TLDR
Although these analyses were potentially limited by the use of clinical trial data and not prospective data from a study conducted solely for validation purposes, the PSQ demonstrated robust psychometric properties and is a valid instrument for assessing sleep and sleep improvements in subjects with moderate-to-severe RLS symptoms.
Effect of pH on disintegration and dissolution of ketoconazole tablets.
TLDR
In the buffer solutions tested, dissolution but not disintegration of ketoconazole tablets is pH-dependent, and the characteristics of 200- and 400-mg doses of ketconazole are similar at pH 3.5.
Azathioprine Metabolism: Pharmacokinetics of 6‐Mercaptopurine, 6‐Thiouric Acid and 6‐Thioguanine Nucleotides in Renal Transplant Patients
TLDR
The persistence of TGN in body tissues thus provides a pharmacokinetic rationale for the conventional once or twice daily AZA regimen, and the long elimination t1/2 may also predispose patients to excessive accumulation of the active metabolite and gradual development of T GN‐induced myelosuppression.
...
1
2
3
4
5
...