Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea.
Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor
- F. Pamplona, J. Ferreira, R. N. Takahashi
- Biology, MedicineProceedings of the National Academy of Sciences
- 12 November 2012
It is shown that the anti-inflammatory lipid lipoxin A4 is an endogenous allosteric enhancer of the CB1 cannabinoid receptor, and displayed a CB1 receptor-dependent protective effect against β-amyloid (1–40)-induced spatial memory impairment in mice.
Kinins in pain and inflammation
Kinin B1 receptors: key G‐protein‐coupled receptors and their role in inflammatory and painful processes
- J. Calixto, R. Medeiros, E. Fernandes, J. Ferreira, D. Cabrini, M. Campos
- BiologyBritish Journal of Pharmacology
- 1 December 2004
The main advances achieved in the last 5 years about the participation of kinin B1 receptors in painful and inflammatory disorders are remarked and some groups of chronic diseases are pointed out, in which the strategic development of nonpeptidic oral‐available and selective B1 receptor antagonists could have a potential relevant therapeutic interest.
Anti-inflammatory and anti-allergic properties of the essential oil and active compounds from Cordia verbenacea.
Pronociceptive response elicited by TRPA1 receptor activation in mice
Naturally occurring antinociceptive substances from plants
- J. Calixto, A. Beirith, J. Ferreira, A. Santos, V. C. Filho, R. Yunes
- Chemistry, MedicinePhytotherapy Research
- 1 September 2000
Despite the progress that has occurred in recent years in the development of therapy, there is still a need for effective and potent analgesics, especially for the treatment of chronic pain. One of…
Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions.
Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice
It is demonstrated that BK produces overt nociception mediated by TRPV1 receptor stimulation, via PLC pathway activation and LOX product formation, which is similar to that caused by capsaicin.