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Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea.
Findings indicate that alpha-humulene and (-)-trans-caryophyllene, derived from the essential oil of C. verbenacea, might represent important tools for the management and/or treatment of inflammatory diseases. Expand
Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor
It is shown that the anti-inflammatory lipid lipoxin A4 is an endogenous allosteric enhancer of the CB1 cannabinoid receptor, and displayed a CB1 receptor-dependent protective effect against β-amyloid (1–40)-induced spatial memory impairment in mice. Expand
Kinins in pain and inflammation
The present review attempted to focus on the contribution of kinins during painful and in ̄ammatory events, as well as to highlight the pharmacological actions of the selective B1 and B2 kinin receptor antagonists and their possible clinical applications. Expand
Kinin B1 receptors: key G‐protein‐coupled receptors and their role in inflammatory and painful processes
The main advances achieved in the last 5 years about the participation of kinin B1 receptors in painful and inflammatory disorders are remarked and some groups of chronic diseases are pointed out, in which the strategic development of nonpeptidic oral‐available and selective B1 receptor antagonists could have a potential relevant therapeutic interest. Expand
Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions.
The contribution of natural products to the discovery of TRP channels and to the development of novel drugs to treat pathological conditions in which these channels are involved is focused on. Expand
Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice
It is demonstrated that BK produces overt nociception mediated by TRPV1 receptor stimulation, via PLC pathway activation and LOX product formation, which is similar to that caused by capsaicin. Expand
Mechanisms involved in the nociception produced by peripheral protein kinase c activation in mice
The results of the present study have shown that PMA injection into the mouse paw results in PKC activation as well as a relatively delayed, but long‐lasting, overt nociceptive behaviour in mice, and demonstrate that PKCactivation exerts a critical role in modulating the excitability of sensory neurons. Expand
Anti-inflammatory and anti-allergic properties of the essential oil and active compounds from Cordia verbenacea.
Cordia verbenacea essential oil or its constituents might represent new therapeutic options for the treatment of inflammatory diseases and some active compounds, probably by interfering with TNFalpha production, showed marked anti-inflammatory effects. Expand
Pronociceptive response elicited by TRPA1 receptor activation in mice
It is demonstrated that the TRPA1 agonist allyl isothiocyanate produces a consistent nociceptive response when injected into the mouse paw, an effect that seems to be mediated via activation of TRP1 receptor and dependent on the capsaicin-sensitive fibers, release of histamine by mast cells and participation of tachykinins. Expand
Antinociceptive Properties of Mixture of α-Amyrin and β-Amyrin Triterpenes: Evidence for Participation of Protein Kinase C and Protein Kinase A Pathways
The mixture of the two pentacyclic triterpenes α-amyrin and β-amyrin, isolated from the resin of Protium kleinii and given by intraperitoneal (i.p.) or oral (p.o.) routes, caused dose-related andExpand