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Severity of acute pain after childbirth, but not type of delivery, predicts persistent pain and postpartum depression
TLDR
Cesarean delivery does not increase the risk of persistent pain and postpartum depression, and the severity of the acute pain response to childbirth predicts persistent morbidity, suggesting the need to more carefully address pain treatment in the days following childbirth. Expand
Polyanalgesic Consensus Conference 2007: Recommendations for the Management of Pain by Intrathecal (Intraspinal) Drug Delivery: Report of an Interdisciplinary Expert Panel
TLDR
An expert panel of physicians convened in 2007 to update previous recommendations and to form guidelines for the rational use of intrathecal opioid and nonopioid agents. Expand
Animal models and the prediction of efficacy in clinical trials of analgesic drugs: A critical appraisal and call for uniform reporting standards
TLDR
This poster presents a poster presented at the 2016 U.S. Conference on Veterinary Medicine and Anaesthetics, entitled “Oncology and Anaesthesiology: Foundations of Comparative Oncology Research, 2nd Ed.” (June 2016). Expand
Spinal Cannabinoid Receptor Type 2 Activation Reduces Hypersensitivity and Spinal Cord Glial Activation after Paw Incision
TLDR
These data indicate that intrathecal administration of cannabinoid receptor agonists may provide postoperative analgesia while reducing spinal glial activation, and that selective cannabinoid 2 receptor agonist may do so without central side effects. Expand
Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain
TLDR
The data suggest that PSNL induces over‐production of PGs in peripheral tissues and that PGs probably sensitize nociceptors and are involved in central plasticity and sensitization at the spinal cord level, thus contributing to the maintenance of tactile allodynia. Expand
Intravenous Remifentanil Produces Withdrawal Hyperalgesia in Volunteers with Capsaicin-Induced Hyperalgesia
TLDR
It is demonstrated that acute opioid exposure enhances hypersensitivity for hours after exposure, which could increase the dose of opioid required for postoperative analgesia and enhance, rather than inhibit, postoperative pain. Expand
Polyanalgesic Consensus Conference 2003: an update on the management of pain by intraspinal drug delivery-- report of an expert panel.
TLDR
A Polyanalgesic Consensus Conference 2003 was organized to review the literature on intraspinal drug infusion and develop guidelines for optimizing drug dosage and concentration and to clarify issues pertaining to compounding of drugs. Expand
Effects of Laparotomy on Spontaneous Exploratory Activity and Conditioned Operant Responding in the Rat: A Model for Postoperative Pain
TLDR
The effects of morphine and ketorolac alone and in combination were consistent with the reported analgesic efficacy and occurrence of side effects found with these agents clinically. Expand
Epidural clonidine analgesia following surgery: phase I.
TLDR
The results suggest that hemodynamic depression and short-lasting analgesia may limit the usefulness of bolus epidural clonidine analgesia in the postoperative setting. Expand
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