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etoposide phosphate

Known as: ETOP, etoposide phosphate [Chemical/Ingredient] 
A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks… Expand
National Institutes of Health

Related topics

Related topics

28 relations

Broader (3)

Antineoplastic AgentsEtoposideOrganophosphorus Compounds

Narrower (3)

BMY-40481EtophosEtopophos
Bladder NeoplasmBrain NeoplasmsChronic Lymphocytic LeukemiaDrug Allergy
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Papers overview

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Highly Cited
2008
Highly Cited
2008
Assessment of DNA double-strand breaks and gammaH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone.
Double-strand breaks (DSBs) are highly deleterious DNA lesions as they lead to chromosome aberrations and/or apoptosis. The… Expand
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Highly Cited
2008
Highly Cited
2008
A Lin's method approach to finding and continuing heteroclinic connections involving periodic orbits
We present a numerical method for finding and continuing heteroclinic connections of vector fields that involve periodic orbits… Expand
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2005
2005
DNA Lesion-specific Co-localization of the Mre11/Rad50/Nbs1 (MRN) Complex and Replication Protein A (RPA) to Repair Foci*
The DNA damage response, triggered by DNA replication stress or DNA damage, involves the activation of DNA repair and cell cycle… Expand
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Highly Cited
2004
Highly Cited
2004
Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years…
PURPOSE P-glycoprotein (Pgp) is strongly inhibited by PSC-833. A chemotherapy dose-escalation study was performed with PSC-833 in… Expand
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Highly Cited
2004
Highly Cited
2004
Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins.
During the safety evaluation process of new drugs and chemicals, a battery of genotoxicity tests is conducted starting with in… Expand
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Highly Cited
2002
Highly Cited
2002
ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53*
In response to DNA damage, ataxia-telangiectasia mutant and ataxia-telangiectasia and Rad-3 activate p53, resulting in either… Expand
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Highly Cited
2002
Highly Cited
2002
Treatment of unresectable and metastatic hepatoblastoma: a pediatric oncology group phase II study.
PURPOSE To estimate the disease-response rate, proportion of patients whose tumors can be made resectable, event-free survival… Expand
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Highly Cited
1997
Highly Cited
1997
Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.
The mrp (multidrug resistance protein) gene has been associated with the multidrug resistance of cancer cells in vitro and in… Expand
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Review
1996
Review
1996
Etoposide phosphate: what, why, where, and how?
The podophyllotoxin derivatives etoposide and teniposide are active in the treatment of a variety of malignant conditions. Both… Expand
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Highly Cited
1988
Highly Cited
1988
Anti-tumor effects of antibody-alkaline phosphatase conjugates in combination with etoposide phosphate.
Two anti-tumor monoclonal antibodies, L6 (anticarcinoma) and 1F5 (anti-B lymphoma), were covalently linked to alkaline… Expand
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