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etoposide phosphate

Known as: ETOP, etoposide phosphate [Chemical/Ingredient] 
A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks… 
National Institutes of Health

Related topics

Related topics

28 relations

Broader (3)

Antineoplastic AgentsEtoposideOrganophosphorus Compounds

Narrower (3)

BMY-40481EtophosEtopophos
Bladder NeoplasmBrain NeoplasmsChronic Lymphocytic LeukemiaDrug Allergy
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Papers overview

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Highly Cited
2013
Highly Cited
2013
High-risk retinoblastoma based on international classification of retinoblastoma: analysis of 519 enucleated eyes.
Highly Cited
2004
Highly Cited
2004
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.
Replication protein A (RPA) is a single-stranded DNA (ssDNA) binding protein involved in various processes, including nucleotide… 
Highly Cited
2004
Highly Cited
2004
Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years…
PURPOSE P-glycoprotein (Pgp) is strongly inhibited by PSC-833. A chemotherapy dose-escalation study was performed with PSC-833 in… 
2004
2004
Etoposide phosphate, the water soluble prodrug of etoposide
Apoptosis, or programmed cell death, is an orderly and genetically controlled form of cell death. In a morphological sense, it… 
Highly Cited
2002
Highly Cited
2002
ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53*
In response to DNA damage, ataxia-telangiectasia mutant and ataxia-telangiectasia and Rad-3 activate p53, resulting in either… 
Highly Cited
2002
Highly Cited
2002
Treatment of unresectable and metastatic hepatoblastoma: a pediatric oncology group phase II study.
PURPOSE To estimate the disease-response rate, proportion of patients whose tumors can be made resectable, event-free survival… 
Review
1998
Review
1998
Etoposide: four decades of development of a topoisomerase II inhibitor.
  • K. Hande
  • European journal of cancer
  • 1998
  • Corpus ID: 39068267
Highly Cited
1997
Highly Cited
1997
Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.
The mrp (multidrug resistance protein) gene has been associated with the multidrug resistance of cancer cells in vitro and in… 
Review
1996
Review
1996
Etoposide phosphate: what, why, where, and how?
The podophyllotoxin derivatives etoposide and teniposide are active in the treatment of a variety of malignant conditions. Both… 
Highly Cited
1988
Highly Cited
1988
Anti-tumor effects of antibody-alkaline phosphatase conjugates in combination with etoposide phosphate.
Two anti-tumor monoclonal antibodies, L6 (anticarcinoma) and 1F5 (anti-B lymphoma), were covalently linked to alkaline… 
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