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etoposide phosphate

Known as: ETOP, etoposide phosphate [Chemical/Ingredient] 
A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Double-strand breaks (DSBs) are highly deleterious DNA lesions as they lead to chromosome aberrations and/or apoptosis. The… Expand
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Highly Cited
2008
Highly Cited
2008
We present a numerical method for finding and continuing heteroclinic connections of vector fields that involve periodic orbits… Expand
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2005
2005
The DNA damage response, triggered by DNA replication stress or DNA damage, involves the activation of DNA repair and cell cycle… Expand
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Highly Cited
2004
Highly Cited
2004
PURPOSE P-glycoprotein (Pgp) is strongly inhibited by PSC-833. A chemotherapy dose-escalation study was performed with PSC-833 in… Expand
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Highly Cited
2004
Highly Cited
2004
During the safety evaluation process of new drugs and chemicals, a battery of genotoxicity tests is conducted starting with in… Expand
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Highly Cited
2002
Highly Cited
2002
In response to DNA damage, ataxia-telangiectasia mutant and ataxia-telangiectasia and Rad-3 activate p53, resulting in either… Expand
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Highly Cited
2002
Highly Cited
2002
PURPOSE To estimate the disease-response rate, proportion of patients whose tumors can be made resectable, event-free survival… Expand
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Highly Cited
1997
Highly Cited
1997
The mrp (multidrug resistance protein) gene has been associated with the multidrug resistance of cancer cells in vitro and in… Expand
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Review
1996
Review
1996
The podophyllotoxin derivatives etoposide and teniposide are active in the treatment of a variety of malignant conditions. Both… Expand
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Highly Cited
1988
Highly Cited
1988
Two anti-tumor monoclonal antibodies, L6 (anticarcinoma) and 1F5 (anti-B lymphoma), were covalently linked to alkaline… Expand
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