etoposide phosphate

Known as: ETOP, etoposide phosphate [Chemical/Ingredient] 
A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2018
051019882018

Papers overview

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2011
2011
BACKGROUND Analysis of 52 eyes with high-risk retinoblastoma managed with postenucleation adjuvant chemotherapy using vincristine… (More)
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2008
2008
Double-strand breaks (DSBs) are highly deleterious DNA lesions as they lead to chromosome aberrations and/or apoptosis. The… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE P-glycoprotein (Pgp) is strongly inhibited by PSC-833. A chemotherapy dose-escalation study was performed with PSC-833 in… (More)
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Highly Cited
2002
Highly Cited
2002
In response to DNA damage, ataxia-telangiectasia mutant and ataxia-telangiectasia and Rad-3 activate p53, resulting in either… (More)
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2002
2002
Etoposide is commonly used in a variety of malignancies. A well known but rare toxicity are hypersensitivity reactions, usually… (More)
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2002
2002
PURPOSE To estimate the disease-response rate, proportion of patients whose tumors can be made resectable, event-free survival… (More)
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Highly Cited
1997
Highly Cited
1997
The mrp (multidrug resistance protein) gene has been associated with the multidrug resistance of cancer cells in vitro and in… (More)
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1995
1995
Etoposide phosphate (EP) is a water-soluble derivative of etoposide (VP-16), a semisynthetic podophyllotoxin which is useful in… (More)
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1995
1995
PURPOSE To determine the bioavailability (F) and the pharmacokinetic profile of both etoposide and its prodrug, etoposide… (More)
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Highly Cited
1988
Highly Cited
1988
Two anti-tumor monoclonal antibodies, L6 (anticarcinoma) and 1F5 (anti-B lymphoma), were covalently linked to alkaline… (More)
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