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etoposide phosphate
Known as:
ETOP
, etoposide phosphate [Chemical/Ingredient]
A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks…
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National Institutes of Health
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Related topics
Related topics
28 relations
Broader (3)
Antineoplastic Agents
Etoposide
Organophosphorus Compounds
Narrower (3)
BMY-40481
Etophos
Etopophos
Bladder Neoplasm
Brain Neoplasms
Chronic Lymphocytic Leukemia
Drug Allergy
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
High-risk retinoblastoma based on international classification of retinoblastoma: analysis of 519 enucleated eyes.
S. Kaliki
,
C. Shields
,
+4 authors
R. Eagle
Ophthalmology
2013
Corpus ID: 20598975
Highly Cited
2004
Highly Cited
2004
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.
W. Block
,
Yaping Yu
,
S. Lees-Miller
Nucleic acids research
2004
Corpus ID: 19362325
Replication protein A (RPA) is a single-stranded DNA (ssDNA) binding protein involved in various processes, including nucleotide…
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Highly Cited
2004
Highly Cited
2004
Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years…
J. Kolitz
,
S. George
,
+11 authors
R. Larson
Journal of clinical oncology : official journal…
2004
Corpus ID: 11549906
PURPOSE P-glycoprotein (Pgp) is strongly inhibited by PSC-833. A chemotherapy dose-escalation study was performed with PSC-833 in…
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2004
2004
Etoposide phosphate, the water soluble prodrug of etoposide
H. Guchelaar
,
A. Vermes
,
I. Vermes
,
C. Haanen
Pharmacy World and Science
2004
Corpus ID: 12710335
Apoptosis, or programmed cell death, is an orderly and genetically controlled form of cell death. In a morphological sense, it…
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Highly Cited
2002
Highly Cited
2002
ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53*
D. Tang
,
Dongcheng Wu
,
+6 authors
A. Ingram
The Journal of Biological Chemistry
2002
Corpus ID: 26750451
In response to DNA damage, ataxia-telangiectasia mutant and ataxia-telangiectasia and Rad-3 activate p53, resulting in either…
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Highly Cited
2002
Highly Cited
2002
Treatment of unresectable and metastatic hepatoblastoma: a pediatric oncology group phase II study.
H. Katzenstein
,
W. London
,
+4 authors
L. Bowman
Journal of clinical oncology : official journal…
2002
Corpus ID: 11293628
PURPOSE To estimate the disease-response rate, proportion of patients whose tumors can be made resectable, event-free survival…
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Review
1998
Review
1998
Etoposide: four decades of development of a topoisomerase II inhibitor.
K. Hande
European journal of cancer
1998
Corpus ID: 39068267
Highly Cited
1997
Highly Cited
1997
Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.
A. Lorico
,
G. Rappa
,
R. Finch
,
D. Yang
,
R. Flavell
,
A. Sartorelli
Cancer research
1997
Corpus ID: 24664552
The mrp (multidrug resistance protein) gene has been associated with the multidrug resistance of cancer cells in vitro and in…
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Review
1996
Review
1996
Etoposide phosphate: what, why, where, and how?
L. Schacter
Seminars in oncology
1996
Corpus ID: 40075332
The podophyllotoxin derivatives etoposide and teniposide are active in the treatment of a variety of malignant conditions. Both…
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Highly Cited
1988
Highly Cited
1988
Anti-tumor effects of antibody-alkaline phosphatase conjugates in combination with etoposide phosphate.
P. Senter
,
M. Saulnier
,
+4 authors
K. Hellström
Proceedings of the National Academy of Sciences…
1988
Corpus ID: 41353971
Two anti-tumor monoclonal antibodies, L6 (anticarcinoma) and 1F5 (anti-B lymphoma), were covalently linked to alkaline…
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