FAQ

etoposide phosphate

Known as: ETOP, etoposide phosphate [Chemical/Ingredient] 
A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2018
051019882018

Related topics

Related topics

22 relations

Broader (3)

Antineoplastic AgentsEtoposideOrganophosphorus Compounds

Narrower (2)

BMY-40481Etopophos
Bladder NeoplasmBrain NeoplasmsChronic Lymphocytic LeukemiaDrug Allergy
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
etoposide phosphate
Drug Allergy
Prostatic Neoplasms
Pregnancy
Leukemia, Myelocytic, Acute
Brain Neoplasms

Papers overview

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2011
2011
Postenucleation adjuvant chemotherapy with vincristine, etoposide, and carboplatin for the treatment of high-risk retinoblastoma.
BACKGROUND Analysis of 52 eyes with high-risk retinoblastoma managed with postenucleation adjuvant chemotherapy using vincristine… (More)
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2008
2008
Assessment of DNA double-strand breaks and gammaH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone.
Double-strand breaks (DSBs) are highly deleterious DNA lesions as they lead to chromosome aberrations and/or apoptosis. The… (More)
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Highly Cited
2004
Highly Cited
2004
Dose escalation studies of cytarabine, daunorubicin, and etoposide with and without multidrug resistance modulation with PSC-833 in untreated adults with acute myeloid leukemia younger than 60 years…
PURPOSE P-glycoprotein (Pgp) is strongly inhibited by PSC-833. A chemotherapy dose-escalation study was performed with PSC-833 in… (More)
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Highly Cited
2002
Highly Cited
2002
ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53.
In response to DNA damage, ataxia-telangiectasia mutant and ataxia-telangiectasia and Rad-3 activate p53, resulting in either… (More)
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2002
2002
Safe administration of etoposide phosphate after hypersensitivity reaction to intravenous etoposide
Etoposide is commonly used in a variety of malignancies. A well known but rare toxicity are hypersensitivity reactions, usually… (More)
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2002
2002
Treatment of unresectable and metastatic hepatoblastoma: a pediatric oncology group phase II study.
PURPOSE To estimate the disease-response rate, proportion of patients whose tumors can be made resectable, event-free survival… (More)
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Highly Cited
1997
Highly Cited
1997
Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione.
The mrp (multidrug resistance protein) gene has been associated with the multidrug resistance of cancer cells in vitro and in… (More)
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1995
1995
Phase I and pharmacokinetic study of etoposide phosphate.
Etoposide phosphate (EP) is a water-soluble derivative of etoposide (VP-16), a semisynthetic podophyllotoxin which is useful in… (More)
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1995
1995
Phase I clinical and pharmacokinetic study of oral etoposide phosphate.
PURPOSE To determine the bioavailability (F) and the pharmacokinetic profile of both etoposide and its prodrug, etoposide… (More)
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Highly Cited
1988
Highly Cited
1988
Anti-tumor effects of antibody-alkaline phosphatase conjugates in combination with etoposide phosphate.
Two anti-tumor monoclonal antibodies, L6 (anticarcinoma) and 1F5 (anti-B lymphoma), were covalently linked to alkaline… (More)
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