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Enantioselective pharmacokinetics and pharmacodynamics of dl‐thero‐mcthylphenidate in children with attention deficit hyperactivity disorder
TLDR
The computer tests revealed a drug‐induced improvement in sustained attention that was entirely attributable to the d‐enantiomer, and there was no evidence to suggest that the effectiveness of d‐methylphenidate was in any way compromised by the presence of its antipode.
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Simultaneous estimation of six anti-diabetic drugs--glibenclamide, gliclazide, glipizide, pioglitazone, repaglinide and rosiglitazone: development of a novel HPLC method for use in the analysis of…
TLDR
The plasma assay was validated for parameters such as specificity, accuracy and extraction recovery, and can be extended for routine analysis of anti-diabetics in pharmaceutical preparations and in biological matrices.
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Enantioselective Pharmacokinetics of dl-threo-Methylphenidate in Humans
TLDR
It was found that chewing the slow release formulation led to a pharmacokinetic profile very similar to that of MPH-IR, suggesting that MPH-SR should not be prescribed for children who chew tablets.
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Determination of rosuvastatin in rat plasma by HPLC: Validation and its application to pharmacokinetic studies.
TLDR
A specific, accurate, precise and reproducible high-performance liquid chromatography method was developed for the estimation of rosuvastatin (RST), a novel, synthetic and potent HMG-CoA inhibitor in rat plasma to determine the pharmacokinetic disposition after a single oral dose to rats.
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Analysis of five HMG-CoA reductase inhibitors-- atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin: pharmacological, pharmacokinetic and analytical overview and development of a new…
TLDR
The proposedHPLC method is simple, selective and could be applicable for routine analysis of HMG-CoA reductase inhibitors in pharmaceutical preparations as well as in vitro metabolism studies of these statins.
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Cranberry juice ingestion and clinical drug-drug interaction potentials; review of case studies and perspectives.
  • N. Srinivas
  • Biology, Medicine
    Journal of pharmacy & pharmaceutical sciences : a…
  • 21 June 2013
TLDR
The summation of the pharmacodynamics data obtained in patients and healthy subjects from different prospectively designed and controlled clinical trials does not provide overwhelming support for the existence of a pharmacodynamic drug interaction for normal cranberry juice ingestion.
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Stereoselective urinary pharmacokinetics of dl-threo-methylphenidate and its major metabolite in humans.
TLDR
Observations suggest that, after oral administration of dl-MPH, the distortion in the ratio of MPH or RA enantiomers in urine samples was attributable to enantioselective presystemic conversion of MPH to RA rather than to en Anti-inflammatory excretion.
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Stereoselective disposition of methylphenidate in children with attention-deficit disorder.
Six boys with attention-deficit disorder were given single doses (5 or 10 mg) of dl-threo-methylphenidate (Ritalin, Ciba-Geigy, Basel, Switzerland). Plasma samples through 8 hr were analyzed by…
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Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives.
TLDR
An exhaustive compilation of the published assays for irinotecan, SN-38 and other metabolite(s), as applicable, is provided to enumerate the validation parameters and applicable conclusions.
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Simultaneous determination of rosuvastatin and fenofibric acid in human plasma by LC-MS/MS with electrospray ionization: assay development, validation and application to a clinical study.
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