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Clinical Pharmacokinetics of Nefazodone
SummaryNefazodone is a new antidepressant drug, chemically unrelated to the tricyclic, tetracyclic or selective serotonin uptake inhibitors. Nefazodone blocks the serotonin 5-HT2 receptors andExpand
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Safety, tolerance, and pharmacokinetic evaluation of cefepime after administration of single intravenous doses.
In this double-blind, single-dose phase I study, the safety and tolerance of cefepime were assessed in 24 healthy male subjects, with ceftazidime as the control drug. Four subjects in each of the sixExpand
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A study of the effect of age and gender on the pharmacokinetics of nefazodone after single and multiple doses.
The single-dose (S-D) and steady-state (S-S) pharmacokinetics of nefazodone (NEF) and two of its pharmacologically active metabolites, hydroxynefazodone (HO-NEF) and m-chlorophenylpiperazine (mCPP),Expand
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Safety, Tolerance, and Preliminary Pharmacokinetics of Nefazodone After Administration of Single and Multiple Oral Doses to Healthy Adult Male Volunteers: A Double‐Blind, Phase I Study
Safety, tolerance, and preliminary pharmacokinetics of nefazodone, a new antidepressant, were assessed in a randomized, double‐blind, parallel group study carried out in two sequential segments: aExpand
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Pharmacokinetics, absolute bioavailability, and disposition of [14C]nefazodone in humans.
The pharmacokinetics and disposition of nefazodone (NEF) were investigated after administration of intravenous (iv) and oral (po) doses to nine healthy men. All volunteers were administered a 5-mgExpand
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Effect of altered gastric emptying and gastrointestinal motility on metformin absorption.
AIMS The purpose of this in vivo human study was to assess the effect of altered gastric emptying and gastrointestinal motility on the absorption of metformin in healthy subjects. METHODS AnExpand
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Coadministration of nefazodone and benzodiazepines: III. A pharmacokinetic interaction study with alprazolam.
This study was conducted to determine the potential for an interaction between nefazodone, a new antidepressant, and alprazolam after single- and multiple-dose administration in a randomized,Expand
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Nonlinear Pharmacokinetics of Nefazodone After Escalating Single and Multiple Oral Doses
The single‐ and multiple‐dose pharmacokinetics of nefazodone and its metabolites, hydroxynefazodone, p‐hydroxynefazodone, and m‐chlorophenylpiperazine were investigated in two groups of 18 healthyExpand
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Phase I study of multiple-dose cefprozil and comparison with cefaclor.
The objectives of this study were to assess the safety and tolerance of cefprozil, to characterize the pharmacokinetics of cefprozil after administration of multiple doses of the drug, and to compareExpand
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Dose proportionality of stavudine in hiv seropositive asymptomatic subjects: Application to bioequivalence assessment of various capsule formulations
The dose proportionality and bioequivalence of the capsule formulations used in clinical trials and the proposed commercial formulations of stavudine were assessed in an openlabel, single‐dose,Expand
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